Navigation Links
CWRU dental researchers discover how an oral bacterium can trigger colorectal cancer
Date:8/14/2013

Researchers from Case Western Reserve University School of Dental Medicine have discovered how a common oral bacterium can contribute to colorectal cancer, a finding that opens promising new research avenues for the development of approaches to prevent and treat the disease.

"We found this cancer is linked to an infection from [the bacterium]," said Yiping Han, professor of periodontics at the dental school and the study's lead investigator. "This discovery creates the potential for new diagnostic tools and therapies to treat and prevent the cancer."

The results of the research appear in the current issue of Cell Host & Microbe, in conjunction with a second study from a different research group that highlights how the bacteria can speed the accumulation of cancerous cells.

The researchers also learned how to prevent the microorganism, called Fusobacterium nucleatum (Fn), from attaching to colon cells and potentially triggering a cascade of changes that can lead to cancer.

The latest findings advance research from 2011, in which Han and her team identified an adhesive molecule on Fn's surface, called FadA, which can attach to VE-cadherin, a cell receptor from the cadherin group on blood vessels.

As Han completed the work on FadA and VE-cadherin, researchers from Harvard University and the University of British Columbia discovered the presence of Fn was higher in malignant tumors compared to the surrounding tissue.

Han said she immediately suspected Fn interacted with cells in the colon similarly to those in blood vessels and shifted her lab's work to focus on colorectal cancer.

"This was one of those serendipitous scientific moments in making this discovery," Han said.

Because her lab was able to track Fn's ability to attach to the VE-cadherin receptor on blood vessels, Han said it didn't take long before her team found how FadA attached to the E-cadherin receptor on cells in the colon.

Subsequently, FadA's attachment to E-cadherin set in motion a protein called -catenin, which, among its many functions, produces two important actions in the cancer process: an inflammatory response that alters the immune system, and another that spurs cancer cell growth.

Han's lab designed a novel synthetic peptide that prevents FadA from attaching to E-cadherin and inciting actions that lead to cancer development.

They also found that the FadA gene levels are 10 to 100 times higher than normal in precancerous and malignant colon polyps.

Thus, Han said, "FadA can be used as a diagnostic marker for early detection of colon cancer. It can also be used to determine if treatment works effectively at reducing Fn load in the colon and the mouth."

A patent application has been filed on work associated with this research.

At the same time, Han emphasized that the results highlight the importance of oral health. Fn is an opportunistic bacterium that increases dramatically in gum disease.


'/>"/>

Contact: Susan Griffith
susan.griffith@case.edu
216-368-1004
Case Western Reserve University
Source:Eurekalert

Related medicine news :

1. Assist to Succeed Holds Open House for New Dental Career Opportunity
2. CE Lectures on the Dental Treatment of Snoring and Sleep Apnea Include Rochester, Cleveland and Ft. Lauderdale, as Sleep Seminar Destinations
3. Mint Dental Alaska Announces Special Offers for New and Current Customers
4. Dallas, TX Gum Disease Treatment Can Now Help Prevent Tooth Loss and Prepare the Mouth for Dental Implants with Laser Gum Surgery from Dr. Michael Neeley
5. LSUHSC Dental School awarded $1.8 million for HIV care and education
6. Greenville Oral & Maxillofacial Surgeons Now Treating Removable Dentures with Dental Implants
7. Parlin Dentist Brings Emergency Dental Relief to Local Residents
8. Herald Square Dental Offers Relief from Obstructive Sleep Apnea
9. DentalSpots.com Expands Network Capabilities to Help Fill Texas Dental Jobs
10. Chicago Dentist Jessica Emery Offers Sedation Dentistry Outreach Programs During July to Those with Dental Phobias
11. California Dental Association Offers Tips to Avoid Dental Emergencies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... ... March 28, 2017 , ... ... medical society dedicated to advancing the science and clinical practice of radiosurgery, ... RSSearch Patient Registry, a multi-institutional, observational registry established to standardize data collection ...
(Date:3/28/2017)... ... March 28, 2017 , ... Alert Sentry Group LLC., a ... Personal Emergency Response Systems), the iSAFE and the iSAFE Plus. These iSAFE products are ... of their kind, the iSAFE and iSAFE Plus offer direct GPS Location and two-way ...
(Date:3/28/2017)... ... March 28, 2017 , ... WHO: , Dr. Paul Thomas; Dr. ... , Medical doctors and PhD scientists will speak to the press on behalf of ... support of an independent vaccine safety commission. , WHERE: , Zenger Room, National ...
(Date:3/28/2017)... ... 28, 2017 , ... The Radiology Business Management Association (RBMA) is ... its new executive director. Mr. Still was selected through a careful months-long search by ... he is known to our members, has been a part of building the RBMA ...
(Date:3/28/2017)... ... March 28, 2017 , ... Award-winning medical group ... serving as new board chair for Orange County health care system CalOptima Friday. ... of soon-to-be former chair Mark Refowitz’s term, which runs through June 30 of ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... STRASBOURG, France and TEL AVIV, Israel ... opening a subsidiary in Israel . This new ... , will be mostly dedicated to research and development of novel ... Emosis Ltd will also, when relevant, locally support commercialization and sales ... ...
(Date:3/28/2017)...  CASI Pharmaceuticals, Inc. (Nasdaq: CASI), a biopharmaceutical ... other unmet medical needs, announced today two poster ... annual meeting.  The first poster to be presented ... ENMD-2076 in Combination with Anti-PD1 in Syngeneic Cancer ... presented on April 4 is entitled " Kinase ...
(Date:3/28/2017)... The global flow cytometry ... by 2025, according to a new study by Grand ... and cancer is expected to upsurge the demand for ... coming years. In addition, higher number of physicians is ... cell therapy, due to adverse effects caused by chemotherapy ...
Breaking Medicine Technology: