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CWRU dental researchers discover how an oral bacterium can trigger colorectal cancer
Date:8/14/2013

Researchers from Case Western Reserve University School of Dental Medicine have discovered how a common oral bacterium can contribute to colorectal cancer, a finding that opens promising new research avenues for the development of approaches to prevent and treat the disease.

"We found this cancer is linked to an infection from [the bacterium]," said Yiping Han, professor of periodontics at the dental school and the study's lead investigator. "This discovery creates the potential for new diagnostic tools and therapies to treat and prevent the cancer."

The results of the research appear in the current issue of Cell Host & Microbe, in conjunction with a second study from a different research group that highlights how the bacteria can speed the accumulation of cancerous cells.

The researchers also learned how to prevent the microorganism, called Fusobacterium nucleatum (Fn), from attaching to colon cells and potentially triggering a cascade of changes that can lead to cancer.

The latest findings advance research from 2011, in which Han and her team identified an adhesive molecule on Fn's surface, called FadA, which can attach to VE-cadherin, a cell receptor from the cadherin group on blood vessels.

As Han completed the work on FadA and VE-cadherin, researchers from Harvard University and the University of British Columbia discovered the presence of Fn was higher in malignant tumors compared to the surrounding tissue.

Han said she immediately suspected Fn interacted with cells in the colon similarly to those in blood vessels and shifted her lab's work to focus on colorectal cancer.

"This was one of those serendipitous scientific moments in making this discovery," Han said.

Because her lab was able to track Fn's ability to attach to the VE-cadherin receptor on blood vessels, Han said it didn't take long before her team found how FadA attached to the E-cadherin receptor on cells
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Contact: Susan Griffith
susan.griffith@case.edu
216-368-1004
Case Western Reserve University
Source:Eurekalert

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