Navigation Links
CWRU dental researchers discover how an oral bacterium can trigger colorectal cancer
Date:8/14/2013

Researchers from Case Western Reserve University School of Dental Medicine have discovered how a common oral bacterium can contribute to colorectal cancer, a finding that opens promising new research avenues for the development of approaches to prevent and treat the disease.

"We found this cancer is linked to an infection from [the bacterium]," said Yiping Han, professor of periodontics at the dental school and the study's lead investigator. "This discovery creates the potential for new diagnostic tools and therapies to treat and prevent the cancer."

The results of the research appear in the current issue of Cell Host & Microbe, in conjunction with a second study from a different research group that highlights how the bacteria can speed the accumulation of cancerous cells.

The researchers also learned how to prevent the microorganism, called Fusobacterium nucleatum (Fn), from attaching to colon cells and potentially triggering a cascade of changes that can lead to cancer.

The latest findings advance research from 2011, in which Han and her team identified an adhesive molecule on Fn's surface, called FadA, which can attach to VE-cadherin, a cell receptor from the cadherin group on blood vessels.

As Han completed the work on FadA and VE-cadherin, researchers from Harvard University and the University of British Columbia discovered the presence of Fn was higher in malignant tumors compared to the surrounding tissue.

Han said she immediately suspected Fn interacted with cells in the colon similarly to those in blood vessels and shifted her lab's work to focus on colorectal cancer.

"This was one of those serendipitous scientific moments in making this discovery," Han said.

Because her lab was able to track Fn's ability to attach to the VE-cadherin receptor on blood vessels, Han said it didn't take long before her team found how FadA attached to the E-cadherin receptor on cells in the colon.

Subsequently, FadA's attachment to E-cadherin set in motion a protein called -catenin, which, among its many functions, produces two important actions in the cancer process: an inflammatory response that alters the immune system, and another that spurs cancer cell growth.

Han's lab designed a novel synthetic peptide that prevents FadA from attaching to E-cadherin and inciting actions that lead to cancer development.

They also found that the FadA gene levels are 10 to 100 times higher than normal in precancerous and malignant colon polyps.

Thus, Han said, "FadA can be used as a diagnostic marker for early detection of colon cancer. It can also be used to determine if treatment works effectively at reducing Fn load in the colon and the mouth."

A patent application has been filed on work associated with this research.

At the same time, Han emphasized that the results highlight the importance of oral health. Fn is an opportunistic bacterium that increases dramatically in gum disease.


'/>"/>

Contact: Susan Griffith
susan.griffith@case.edu
216-368-1004
Case Western Reserve University
Source:Eurekalert

Related medicine news :

1. Assist to Succeed Holds Open House for New Dental Career Opportunity
2. CE Lectures on the Dental Treatment of Snoring and Sleep Apnea Include Rochester, Cleveland and Ft. Lauderdale, as Sleep Seminar Destinations
3. Mint Dental Alaska Announces Special Offers for New and Current Customers
4. Dallas, TX Gum Disease Treatment Can Now Help Prevent Tooth Loss and Prepare the Mouth for Dental Implants with Laser Gum Surgery from Dr. Michael Neeley
5. LSUHSC Dental School awarded $1.8 million for HIV care and education
6. Greenville Oral & Maxillofacial Surgeons Now Treating Removable Dentures with Dental Implants
7. Parlin Dentist Brings Emergency Dental Relief to Local Residents
8. Herald Square Dental Offers Relief from Obstructive Sleep Apnea
9. DentalSpots.com Expands Network Capabilities to Help Fill Texas Dental Jobs
10. Chicago Dentist Jessica Emery Offers Sedation Dentistry Outreach Programs During July to Those with Dental Phobias
11. California Dental Association Offers Tips to Avoid Dental Emergencies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... ... May 05, 2016 , ... Vitenas Cosmetic Surgery has been ... presented by the American Institute of Architects and the Academy of Architecture for Health. ... Perkins+Will and Harrell Architects, opened to patients in October of 2014. ...
(Date:5/5/2016)... ... 05, 2016 , ... Sun Health registered nurse Brittany Eads ... Care Transitions program at the 9th Annual Orthopedic and Spine Summit ... the Post-Acute Environment Through Effective Transitions of Care.” , Major changes are taking ...
(Date:5/5/2016)... ... May 05, 2016 , ... When stiff ... activity to alleviate the pain that’s a common osteoarthritis (OA) symptom. Yet, numerous ... in people with arthritis. , “Physical therapy exercises are commonly prescribed to ...
(Date:5/5/2016)... Dallas, Texas (PRWEB) , ... May 05, 2016 ... ... and relationship-marketing firm, honored finalists and winners Tuesday evening, May 3, at the ... Dallas, Texas. , Scott Pettigrew, Vice President and Chief Security Officer of ...
(Date:5/5/2016)... ... May 05, 2016 , ... Dermatologic surgeons performed nearly 10 ... and up 27 percent since 2012. , The results of the 2015 ASDS Survey ... increase in skin cancer treatments and the growing popularity of soft-tissue fillers and body ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... OSWEGO, Ore. , May 3, 2016   ... the importance of extending care beyond the implant at ... Sessions, May 4-7 in San Francisco ... with continually delivering the highest quality of patient care ... patients are cared for each and every tomorrow," said ...
(Date:5/3/2016)... , May 3, 2016 ... pay $55 million to a woman who says its ... court awarded Gloria Ristesund $5 million in ...      (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ... accusations against the company. In February, the same court ...
(Date:5/3/2016)... TUSTIN, Calif. , May 3, 2016 /PRNewswire/ ... science teaching tool that shows how a cleanroom ... for classroom discussions about science and technology. ... Manager said, "As a technology company, SSF enthusiastically ... program to help educators foster the next generation ...
Breaking Medicine Technology: