Navigation Links
CWRU School of Medicine researchers discover new molecule linked to late-stage breast cancer
Date:12/17/2012

CLEVELAND -- Researchers at Case Western Reserve University School of Medicine have identified a molecule linked to more aggressive forms of breast cancer a discovery that could point the way to potential cures.

Until this study, the ribonucleic acid (RNA) molecule called miR-181a had never before been tied to breast cancer metastasis. But when scientists found elevated levels of the molecule in late-stage breast cancer tissues, they in turn tested an inhibitor in mouse models. The approach not only prevented metastasis, but also extended the animals' lives.

"Overall, these findings reinforce our belief that the discovery of miR-181 will become a strong predictive biomarker for breast cancer metastasis, and that the high expression of miR-181 in tumor tissues will pave the way for the development of targeted therapies, better prognosis and increased patient survival," said lead researcher William Schiemann, PhD, associate professor of General Medical Sciences (oncology) at the medical school and a member of the Case Comprehensive Cancer Center.

The study appears online today in The Journal of Clinical Investigation (JCI) and will be published in the journal's January 2013 edition. Its authors include scientists at Case Western Reserve's School of Medicine, the Cleveland Clinic and University Hospitals.

"This work, published in the most important journal for patient-based discoveries, points us in the direction of a new genetic change in women with high-risk breast cancer," said Stanton Gerson, MD, director of the Case Comprehensive Cancer Center. "This research will impact the field by focusing us on new targets for treating and preventing metastasis in patients with breast cancer."

As breast-cancer tumors spread, they become less responsive to chemotherapy. Generating a cell-based system to replicate such changes enabled the research team to establish the molecule's effect on breast cancer metastasis. The team also linked high levels of miR-181 with decreased levels of a protein molecule called Bim, which kills cancer cells during chemotherapy. The combination of low Bim levels and elevated miR-181a levels allowed the breast cancers to -metastasize and resist chemotherapy.

"The identification of an RNA that regulates cell death may offer a natural molecule that can resensitize metastatic breast cancers to chemotherapy," Schiemann said.


'/>"/>
Contact: Christine A. Somosi
christine.somosi@case.edu
216-368-6287
Case Western Reserve University
Source:Eurekalert

Related medicine news :

1. Even Preschoolers View the Overweight Negatively
2. Catastrophic Head Injuries to High School Football Players Rising
3. That impulsive, moody preschooler may grow up to be a problem gambler
4. Some Schools Dont Let Kids Carry Asthma Inhalers
5. Awards to 5 IU School of Medicine physicians address critical need for geriatricians
6. Excessive sleepiness may be cause of learning, attention and school problems
7. Study: More Pre-Teens Get Vaccines When Middle Schools Require Them
8. A place to play: Researcher designs schoolyard for children with autism
9. Fees Lead Some Kids to Skip After-School Sports: Survey
10. Outstanding high school students receive awards to stimulate research interest in digestive diseases
11. The Tennessee Car Accident Lawyers at Michael D. Ponce & Associates Alert Public of CDC Survey Revealing Majority of High School Seniors Admitting to Texting Behind Wheel
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2017)... Dalton, GA (PRWEB) , ... July 21, 2017 ... ... provides asset protection and financial consultation services to families and business owners in ... charity drive to raise support for children overcoming sexual assault and physical abuse. ...
(Date:7/21/2017)... Minnesota (PRWEB) , ... July 21, 2017 , ... ... BWBR recently were selected to renovate and improve the Ramsey County Medical Examiners ... adjacent to Regions Hospital, the $2.5 million project is scheduled to start in ...
(Date:7/21/2017)... ... July 21, 2017 , ... The Margarian Law Firm has filed a ... ginger ale for allegedly containing no ginger. Dr. Pepper produces the “Canada Dry” brand ... Gegham Margaryan alleges Canada Dry Ginger Ale claims on its bottle that it is ...
(Date:7/21/2017)... ... July 21, 2017 , ... ... Tears® EyeMist®, the signature product of her research center at Bio-Logic Aqua Research® ... largest population and the greatest number of sufferers of blindness. “We think that ...
(Date:7/20/2017)... ... July 20, 2017 , ... TransPixel Volume 2 is a set of ... FCPX timeline. This effect isolates horizontal and vertical lines of pixels and sorts their ... rotating or flipping animation and can be changed using a drop-down menu. Create amazing ...
Breaking Medicine News(10 mins):
(Date:7/13/2017)... -- RK Logistics Group, Inc. was awarded California ... Fremont, CA headquarters facility where it provides ... San Jose for hi-tech, pharmaceutical and biomedical ... with its Fremont Innovation District, is excited to strategically partner ... to the hundreds of biotech, pharma and biomed companies throughout ...
(Date:7/11/2017)... Research Corp., also known as ,The Epigenetics Company, announced today the release ... manner using the myDNAge ™ test. Based on Horvath,s Clock, so ... and biostatistics at the David Geffen School of Medicine at UCLA ... DNAge ™ technology is used to analyze DNA methylation patterns of ... ...
(Date:7/11/2017)... Fla. , July 11, 2017  Dr. Echenberg, founder of Echenberg ... therapy program to patients who suffer from painful intercourse and other painful ... and vaginal atrophy due to menopause. ... VuVatech LLC ... , created by Sarasota, Florida -based start-up company, VuVatech ...
Breaking Medicine Technology: