Navigation Links
CWRU School of Medicine researchers discover new molecule linked to late-stage breast cancer
Date:12/17/2012

CLEVELAND -- Researchers at Case Western Reserve University School of Medicine have identified a molecule linked to more aggressive forms of breast cancer a discovery that could point the way to potential cures.

Until this study, the ribonucleic acid (RNA) molecule called miR-181a had never before been tied to breast cancer metastasis. But when scientists found elevated levels of the molecule in late-stage breast cancer tissues, they in turn tested an inhibitor in mouse models. The approach not only prevented metastasis, but also extended the animals' lives.

"Overall, these findings reinforce our belief that the discovery of miR-181 will become a strong predictive biomarker for breast cancer metastasis, and that the high expression of miR-181 in tumor tissues will pave the way for the development of targeted therapies, better prognosis and increased patient survival," said lead researcher William Schiemann, PhD, associate professor of General Medical Sciences (oncology) at the medical school and a member of the Case Comprehensive Cancer Center.

The study appears online today in The Journal of Clinical Investigation (JCI) and will be published in the journal's January 2013 edition. Its authors include scientists at Case Western Reserve's School of Medicine, the Cleveland Clinic and University Hospitals.

"This work, published in the most important journal for patient-based discoveries, points us in the direction of a new genetic change in women with high-risk breast cancer," said Stanton Gerson, MD, director of the Case Comprehensive Cancer Center. "This research will impact the field by focusing us on new targets for treating and preventing metastasis in patients with breast cancer."

As breast-cancer tumors spread, they become less responsive to chemotherapy. Generating a cell-based system to replicate such changes enabled the research team to establish the molecule's effect on breast cancer metastasis. The team also linked high levels of miR-181 with decreased levels of a protein molecule called Bim, which kills cancer cells during chemotherapy. The combination of low Bim levels and elevated miR-181a levels allowed the breast cancers to -metastasize and resist chemotherapy.

"The identification of an RNA that regulates cell death may offer a natural molecule that can resensitize metastatic breast cancers to chemotherapy," Schiemann said.


'/>"/>
Contact: Christine A. Somosi
christine.somosi@case.edu
216-368-6287
Case Western Reserve University
Source:Eurekalert

Related medicine news :

1. Even Preschoolers View the Overweight Negatively
2. Catastrophic Head Injuries to High School Football Players Rising
3. That impulsive, moody preschooler may grow up to be a problem gambler
4. Some Schools Dont Let Kids Carry Asthma Inhalers
5. Awards to 5 IU School of Medicine physicians address critical need for geriatricians
6. Excessive sleepiness may be cause of learning, attention and school problems
7. Study: More Pre-Teens Get Vaccines When Middle Schools Require Them
8. A place to play: Researcher designs schoolyard for children with autism
9. Fees Lead Some Kids to Skip After-School Sports: Survey
10. Outstanding high school students receive awards to stimulate research interest in digestive diseases
11. The Tennessee Car Accident Lawyers at Michael D. Ponce & Associates Alert Public of CDC Survey Revealing Majority of High School Seniors Admitting to Texting Behind Wheel
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... (PRWEB) , ... March 29, 2017 , ... AvePoint ... seventh North American office location in Richmond, Virginia, located at the Riverfront Plaza, 901 ... attended by Lieutenant Governor of Virginia Ralph S. Northam and Mayor of Richmond Levar ...
(Date:3/28/2017)... ... , ... For many women, getting birth control isn’t as easy as it should be. In ... access to a health care facility or a pharmacy within 60 minutes of where they ... or for many who are faced with health or personal issues that leave them homebound. ...
(Date:3/28/2017)... ... March 28, 2017 , ... Revolution for Truth ... Congress to protect parental rights and civil liberties, and to restore transparency within ... The demonstration coincides with a press conference taking place Friday morning calling on ...
(Date:3/28/2017)... ... March 28, 2017 , ... Medforce Technologies, Inc., a ... announce it has joined the National Association for Home Care and Hospice (NAHC), ... disabled, and dying Americans of all ages and the caregiver who provide them ...
(Date:3/28/2017)... ... March 28, 2017 , ... Z-Medica, ... University of Pittsburgh Medical Center (UPMC) will acquire QuikClot® Bleeding Control Kits® (BCK) ... program, developed in association with efforts by the American College of Surgeons, U.S. ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... , March 29, 2017  Maxor National Pharmacy Services, ... that it has named Leah Bailey as ... divisions of the company. With more than ... previous 8 years focused on health care, Bailey joins ... tenure at Prime, Bailey advised the PBM, Specialty, and ...
(Date:3/29/2017)... March 29, 2017  Designers of primary cell wearable ... size by 50% and extend battery life with the ... integrated circuit (PMIC) from Maxim Integrated Products, Inc. (NASDAQ: ... low input voltage of just 0.7V for new high-energy ... Oxide, as well as the more common Alkaline battery ...
(Date:3/29/2017)... , USA, March 29, 2017 Stryker ... that Cares by People magazine, in partnership with Great ... 50 companies on the list. This list highlights the ... have succeeded in business while also demonstrating respect, compassion ... environment.  To determine the companies on ...
Breaking Medicine Technology: