Navigation Links
CU researchers discover target for treating dengue fever
Date:4/17/2014

AURORA, Colo. (April 17, 2014) Two recent papers by a University of Colorado School of Medicine researcher and colleagues may help scientists develop treatments or vaccines for Dengue fever, West Nile virus, Yellow fever, Japanese encephalitis and other disease-causing flaviviruses.

Jeffrey S. Kieft, PhD, associate professor of biochemistry and molecular genetics at the School of Medicine and an early career scientist with the Howard Hughes Medical Institute, and colleagues recently published articles in the scholarly journals eLife and Science that explain how flaviviruses produce a unique RNA molecule that leads to disease.

More than 40 percent of people around the world are at risk of being bitten by mosquitoes infected with the virus that causes Dengue fever and more than 100 million people are infected, according to eLife. Many develop headaches, pain and fever, but some develop a life-threatening condition where tiny blood vessels in the body begin to leak. Other flaviviruses, such as West Nile virus, are rapidly spreading around the globe. Flaviviruses are considered dangerous emerging pathogens.

The eLife paper shows that the virus causing Dengue fever and other closely related viruses like West Nile and Japanese encephalitis use instructions encoded on a single strand of RNA to take over an infected cell and reproduce. The viruses also exploit an enzyme that cells use to destroy RNA to instead produce short stretches of RNA that, among other things, may help the virus avoid the immune system of its host. Ironically, these viruses use a structured RNA molecule to resist an enzyme that normally "chews up" RNA.

The Science paper reveals the discovery that the resistant RNA folds up into an unprecedented "knot-like" structure. The enzyme, normally adept at breaking up RNA structure, encounters this particular structured RNA and cannot "untangle" it; thus the enzyme is thwarted. This is the first time this sort of RNA structure has been observed and it has characteristics that may be amenable to targeting by new drugs. To discover this structure, the researchers used a technique called x-ray crystallography, which allowed them to determine the structures of individual molecules.

This understanding of how an RNA found in many different flaviviruses thwarts a powerful enzyme may help scientists develop treatments or vaccines.


'/>"/>

Contact: Mark Couch
mark.couch@ucdenver.edu
303-724-5377
University of Colorado Denver
Source:Eurekalert

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2017)... ... July 23, 2017 , ... A 20-year-long study ... Louis, and led by the Minneapolis Veterans Administration Health Care System overwhelmingly supports growing ... disease offers very few benefits. , In the cases involved with this study, ...
(Date:7/23/2017)... ... July 23, 2017 , ... Technology ... safety and patient-provider relationships. New tools are helping patients become more actively involved ... Annual Health Care’s Most Wired® survey, released today by the American Hospital Association’s ...
(Date:7/23/2017)... ... July 23, 2017 , ... Viora Ltd., a ... US Patent No. 9,038,640 by the United States Patent and Trademark Office. The ... combination of Switching, Vacuum, and Cooling mechanisms to further increase the efficacy and ...
(Date:7/21/2017)... , ... July 21, 2017 , ... "As a doctor ... lot of pleural catheters available on the market," said an inventor from Center Valley, ... and safety for the patient." , He developed the patent-pending PLEURAL SAFE-t-STAT CATHETER KIT ...
(Date:7/21/2017)... ... July 21, 2017 , ... Roderick Crabbe Insurance, ... to families and business owners in northern Florida, is joining the First Coast ... to area adults with developmental challenges. , The First Coast YMCA offers assistance ...
Breaking Medicine News(10 mins):
(Date:7/5/2017)... 2017   BioLife Solutions , Inc. (NASDAQ: ... of proprietary clinical grade cell and tissue hypothermic ... today announced that it has reached an agreement with ... shareholder, to modify its existing credit facility effective June ... WAVI agreed to exchange its existing $4.25 million credit ...
(Date:6/30/2017)... , June 30, 2017 In vitro ... the start of May, at least ten diagnostic companies ... private investments, public offerings and a loan facility.  The ... to almost $80 million.  Kalorama Information provides a monthly ... its Diagnostics Knowledge Center. ...
(Date:6/30/2017)... 29, 2017  Axium Pharmaceuticals Inc. is a pharmaceutical company aimed ... and alternative dosage forms of existing biologically active molecule. ... ... waterless self-nano emulsifying formula, which is designed to prevent precipitation ... the spray will provide fast onset of action and is ...
Breaking Medicine Technology: