Navigation Links
CU researchers discover target for treating dengue fever
Date:4/17/2014

AURORA, Colo. (April 17, 2014) Two recent papers by a University of Colorado School of Medicine researcher and colleagues may help scientists develop treatments or vaccines for Dengue fever, West Nile virus, Yellow fever, Japanese encephalitis and other disease-causing flaviviruses.

Jeffrey S. Kieft, PhD, associate professor of biochemistry and molecular genetics at the School of Medicine and an early career scientist with the Howard Hughes Medical Institute, and colleagues recently published articles in the scholarly journals eLife and Science that explain how flaviviruses produce a unique RNA molecule that leads to disease.

More than 40 percent of people around the world are at risk of being bitten by mosquitoes infected with the virus that causes Dengue fever and more than 100 million people are infected, according to eLife. Many develop headaches, pain and fever, but some develop a life-threatening condition where tiny blood vessels in the body begin to leak. Other flaviviruses, such as West Nile virus, are rapidly spreading around the globe. Flaviviruses are considered dangerous emerging pathogens.

The eLife paper shows that the virus causing Dengue fever and other closely related viruses like West Nile and Japanese encephalitis use instructions encoded on a single strand of RNA to take over an infected cell and reproduce. The viruses also exploit an enzyme that cells use to destroy RNA to instead produce short stretches of RNA that, among other things, may help the virus avoid the immune system of its host. Ironically, these viruses use a structured RNA molecule to resist an enzyme that normally "chews up" RNA.

The Science paper reveals the discovery that the resistant RNA folds up into an unprecedented "knot-like" structure. The enzyme, normally adept at breaking up RNA structure, encounters this particular structured RNA and cannot "untangle" it; thus the enzyme is thwarted. This is the first time this sort of RNA structure has been observed and it has characteristics that may be amenable to targeting by new drugs. To discover this structure, the researchers used a technique called x-ray crystallography, which allowed them to determine the structures of individual molecules.

This understanding of how an RNA found in many different flaviviruses thwarts a powerful enzyme may help scientists develop treatments or vaccines.


'/>"/>

Contact: Mark Couch
mark.couch@ucdenver.edu
303-724-5377
University of Colorado Denver
Source:Eurekalert

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/15/2018)... , ... August 15, 2018 , ... Today David Hyde ... Kickstarter. , Born out of a desire for confidence and comfort year-round, ... and body odor – even in the hottest, most humid of climates. , The ...
(Date:8/14/2018)... ... August 14, 2018 , ... Gastro Health, LLC (“Gastro ... for healthcare executives Simon Frisch and Chris Weinstein, who have been appointed Senior ... roles at a time of tremendous growth for the group, which has increased ...
(Date:8/11/2018)... ... 2018 , ... Dr. Siavash Eftekhari, Oral and Maxillofacial Surgeon at Monarch ... outpost trip to deliver dental care in impoverished communities. Along with a team of ... his time to help deliver care to over 550 individuals in need. , This ...
(Date:8/9/2018)... (PRWEB) , ... August 09, 2018 , ... ... not realize their implants have ruptured, according to cross-referenced data from The American ... and silicone gel implant rupture rates monitored by the FDA. As an MRI ...
(Date:8/9/2018)... ... August 09, 2018 , ... ... Kathy Coover and the company’s independent distributors, customers, and employees, the newly established ... of fundraising, exceeding the $2 million goal. 100 percent of the donations will ...
Breaking Medicine News(10 mins):
(Date:8/9/2018)... ... , ... Autism is a developmental disorder affecting more than 3.5 million Americans’ ... in 68 people have the disorder), chances are you know someone on the autism ... with autism methods of communication and tactics to interact with others. These options help ...
(Date:8/7/2018)... ... August 06, 2018 , ... Drs. Jonathan and ... MS using laser dentistry techniques. Using their BIOLASE WaterLase® dental laser, this modern ... REPAIR Perio™. , Affecting the lives of millions of Americans, gum disease can ...
(Date:8/7/2018)... ... August 07, 2018 , ... ... role of Sanarus Technologies President, effective immediately. Mr. Stark will lead all ... experience in medical device toward finding new and innovative ways to advance ...
Breaking Medicine Technology: