Navigation Links
CU researchers discover target for treating dengue fever
Date:4/17/2014

AURORA, Colo. (April 17, 2014) Two recent papers by a University of Colorado School of Medicine researcher and colleagues may help scientists develop treatments or vaccines for Dengue fever, West Nile virus, Yellow fever, Japanese encephalitis and other disease-causing flaviviruses.

Jeffrey S. Kieft, PhD, associate professor of biochemistry and molecular genetics at the School of Medicine and an early career scientist with the Howard Hughes Medical Institute, and colleagues recently published articles in the scholarly journals eLife and Science that explain how flaviviruses produce a unique RNA molecule that leads to disease.

More than 40 percent of people around the world are at risk of being bitten by mosquitoes infected with the virus that causes Dengue fever and more than 100 million people are infected, according to eLife. Many develop headaches, pain and fever, but some develop a life-threatening condition where tiny blood vessels in the body begin to leak. Other flaviviruses, such as West Nile virus, are rapidly spreading around the globe. Flaviviruses are considered dangerous emerging pathogens.

The eLife paper shows that the virus causing Dengue fever and other closely related viruses like West Nile and Japanese encephalitis use instructions encoded on a single strand of RNA to take over an infected cell and reproduce. The viruses also exploit an enzyme that cells use to destroy RNA to instead produce short stretches of RNA that, among other things, may help the virus avoid the immune system of its host. Ironically, these viruses use a structured RNA molecule to resist an enzyme that normally "chews up" RNA.

The Science paper reveals the discovery that the resistant RNA folds up into an unprecedented "knot-like" structure. The enzyme, normally adept at breaking up RNA structure, encounters this particular structured RNA and cannot "untangle" it; thus the enzyme is thwarted. This is the first time this sort of RNA structure has been observed and it has characteristics that may be amenable to targeting by new drugs. To discover this structure, the researchers used a technique called x-ray crystallography, which allowed them to determine the structures of individual molecules.

This understanding of how an RNA found in many different flaviviruses thwarts a powerful enzyme may help scientists develop treatments or vaccines.


'/>"/>

Contact: Mark Couch
mark.couch@ucdenver.edu
303-724-5377
University of Colorado Denver
Source:Eurekalert

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... 27, 2016 , ... TherapySites, the leading website ... Tennessee Counseling Association. This new relationship allows TherapySites to continue to ... adding exclusive benefits and promotional offers. , "TCA is extremely excited about this ...
(Date:6/27/2016)... ... June 27, 2016 , ... A revolution is underway. ... transport experience for the millions of people who require these medical transport services ... industry through the use of technology. Now, SmartEMS has put forth an industry-changing ...
(Date:6/26/2016)... ... 27, 2016 , ... Quality metrics are proliferating in cancer care, and are ... the eye of the beholder, according to experts who offered insights and commentary in ... Managed Care. For the full issue, click here . , For the American ...
(Date:6/26/2016)... , ... June 26, 2016 , ... Pixel Film Studios ... X. , "Film editors can give their videos a whole new perspective by using ... - CEO of Pixel Film Studios. , ProSlice Levels contains over 30 Different ...
(Date:6/26/2016)... ... ... a legally blind and certified personal trainer is helping to develop a weight loss fitness ... to fix the two major problems leading the fitness industry today:, , ... They don’t eliminate all the reasons people quit their exercise program ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Research and Markets has announced the ... (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), Functionality (Filler, ... Global Forecast to 2021" report to their offering. ... pharmaceutical excipients market is projected to reach USD 8.1 ... the forecast period 2016 to 2021. ...
(Date:6/23/2016)... LOS ANGELES , June 23, 2016 /PRNewswire/ ... (NASDAQ: CAPR ), a biotechnology company ... first-in-class therapeutics, today announced that patient enrollment in ... progrEssion in Duchenne) has exceeded 50% of its ... its enrollment in the third quarter of 2016, ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 If ... Leaders Scholarship is any indication, the future is in ... at www.diabetesscholars.org by the Diabetes Scholars Foundation ... the way of academic and community service excellence. ... since 2012, and continues to advocate for people with ...
Breaking Medicine Technology: