Navigation Links
CU Cancer Center study: Young patients with metastatic colorectal cancer at higher risk
Date:9/30/2013

Younger patients with colorectal cancer that has spread to other parts of the body represent a high-risk group that is less likely to respond to treatment. Colorectal cancer in patients younger than 40 is more likely to grow despite treatment and young patients are at greater risk of death than people in other age groups.

That's according to research presented to the 2013 European Cancer Congress in Amsterdam. The team of scientists is led by an investigator at University of Colorado Cancer Center.

An analysis of 20,034 patients in 24 phase III clinical trials showed that the youngest and oldest patients had the highest risk of disease progression and death, compared to middle-aged patients. When compared to 57 year-olds, people under 40 had a 30% increased risk of dying from the disease, and, when compared to 61-year-olds, they had a 28% increased risk of their disease spreading during the first year of follow-up.

Colorectal cancer occurs in 4.6% of patients who are younger than 50, the incidence of the disease has been increasing at a rate of 1.5% per year from 1992 to 2005 in this age group. The most dramatic increases have been observed in the 20-29 year-old group, with an annual 5.2% increase in cases in men and a 5.6% increase in women. In the 30-39 year-old group, there has been an annual 3% increase in men and a 2% increase in women.

"The reasons why the incidence of colorectal cancer is increasing in younger patients remain unknown, although genetic predisposition, environmental factors, fewer early cancer detections in this population or a combination of these factors are thought to play a role," said Christopher Lieu, MD, a CU Cancer Center investigator and assistant professor at CU's School of Medicine.

"We carried out this study to see whether age was associated with time until cancer progresses or the patient dies. We also wanted to get a better picture of the ageresponse relationship and identify how risk changes as people age, rather than simply comparing one group (patients younger than 40) with another group (patients older than 40)," Lieu said.

Previous studies in this field have split the population into two mutually exclusive groups, establishing rigid limits between those patients younger than 40 or 50 and those older than that age. The new research, however, did not use such a cut-off approach and includes data spanning all ages.

"The reason we did this is we believe a 49-year-old patient with colorectal cancer may be different than a 20-year-old. By including them in the same group of people younger than 50 years old, we might be mistakenly considering them the same," said Lieu.

Lieu and his colleagues analyzed information from a database of clinical trials in advanced colorectal cancer supported by the French "Aide et Recherche en Cancrologie Digestive" Foundation (ARCAD), which includes the 20,034 patients from 24 phase III clinical trials who were on their first treatment for the disease. There was additional patient data in which patients might be on second or third line treatment, having not responded to their initial therapy. Out of these patients, 20,011 were evaluable for analysis of survival time and time until the disease progressed.

"Analysis of this incredibly large population of patients has allowed us to answer meaningful questions, such as the outcomes of young versus older patients. Our results show young age is associated with worse overall survival and progression-free survival," said Lieu. "Young patients with metastatic colorectal cancer represent a group who are at high risk for treatment failure."

Despite the comprehensive nature of the study, more research will be required to identify why colorectal cancer in younger people appears to be more aggressive. Lieu and collaborators from University of Texas MD Anderson Cancer Center are now looking at the biological differences that may account for the higher risk of death in people under the age of 40.


'/>"/>

Contact: Erika Matich
erika.matich@ucdenver.edu
303-724-1528
University of Colorado Denver
Source:Eurekalert

Related medicine news :

1. New approaches to testing cancer drugs needed -- ESMO press commentary
2. Cancer/Tumor Profiling Market (Personalized Medicine, Biomarker Discovery, Prognosis, Research) Worth $35.03 Billion by 2018 – New Report by MarketsandMarkets
3. New Kantar Health Data Show Number of Newly Diagnosed Breast Cancer Patients in China Will Surpass U.S. by 2015
4. Mesothelioma Awareness Day Sheds Light on Deadly Cancer
5. Diet Doc Hormone Diets & Weight Loss Plans Introduce Hormone Therapy Treatments to Target Belly Fat, the Cause of Many Symptoms of Cancer
6. Chicago Medical Malpractice Lawyers of Salvi, Schostok & Pritchard P.C. Call Attention to Issue of Cancer Misdiagnosis
7. Voices Against Brain Cancer Discusses Recent Finding By Johns Hopkins Researchers Concerning Brain Tumor Treatments
8. Penn Medicine researcher unveils findings on 2 new weapons against thyroid cancer
9. Combining Chinese and Western medicine could lead to new cancer treatments
10. Actos Bladder Cancer Lawsuit: Bernstein Liebhard LLP Comments on Outcome of Nation’s Second Actos Lawsuit Trial
11. Colorectal cancer screening works
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... ... February 12, 2016 , ... Fisher House Foundation Chairman and ... J. Lee, Nevada Military Support Alliance president Scott Bensing, and Peggy Kearns Director, VA ... Southern Nevada Healthcare System. This will be the first Fisher House in Nevada, ...
(Date:2/12/2016)... ... ... Vail knee specialist Robert LaPrade, MD, PhD was named one of ... of physicians establishing, leading and partnering with ambulatory surgery centers across the United States. ... also known as an ASC, is a modern health care facility focused on providing ...
(Date:2/12/2016)... ... February 12, 2016 , ... Donor Network West, the organ procurement organization that ... partnership with San Ramon Regional Medical Center. Under the collaboration, the first of its ... to accommodate a more certain time frame for donor families for the recovery of ...
(Date:2/12/2016)... Land, TX (PRWEB) , ... February 12, 2016 ... ... families of southwest Houston and surrounding communities by continuing it’s commitment to act ... Bend Family Promise. The organization works closely with area homeless families to fulfill ...
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... ... High-Cost Drug Categories: Strategies for Health Plans and PBMs,” an upcoming Feb. 24 ... maintain affordability and access in big-dollar therapeutic categories, such as the $1,000-per-pill hepatitis ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... -- - Cardiac Marker Diagnostic Testing ... Cancer Therapy. - European Point of Care Diagnostic ... - Key Diagnostic Testing Markets. - Molecular Diagnostics ... Testing. - Molecular Diagnostics in Infectious Disease Testing. ... Products World Markets. - Point of Care Diagnostic ...
(Date:2/11/2016)... 2016 Laboratory glassware and plasticware ... These may range from microscope slides to large storage ... from borosilicate glass because of its low weight and ... hand, started gaining popularity over the past decade when ... glass with plastic in several applications due to its ...
(Date:2/11/2016)... 11, 2016   Health 2.0 , the premiere ... technologies, announced today " 10 Year Global Retrospective ", ... over the past ten years.   ... Health 2.0 has served as the preeminent thought-leader in ... thousands of technologies, companies, innovators, and patient-activists through an ...
Breaking Medicine Technology: