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CU-Boulder study sheds light on how our brains get tripped up when we're anxious
Date:9/13/2010

in decision-making by creating a computer model of the brain called a neural network simulation.

"We found that if we increased the amount of inhibition in this simulated brain then our system got much better at making hard choices," said Hannah Snyder, a psychology graduate student who worked with Munakata on the study. "If we decreased inhibition in the brain, then the simulation had much more trouble making choices."

Through their model they looked at the brain mechanisms involved when we choose words. They then tested the model's predictions on people by asking them to think of the first verb that comes to mind when they are presented with a noun.

"We know that making decisions, in this case choosing our words, taps into this left-front region of the brain, called the left ventrolateral prefrontal cortex," Munakata said. "We wanted to figure out what is happening in that part of the brain that lets us make these choices. Our idea here, which we have shown through the word-choosing model, is that there's a fight between neurons in this area of the brain that lets us choose our words."

They then tested the model's predictions that more neural inhibition in the brain makes it easier to make choices by examining the effects of increased and decreased inhibition in people's brains. They increased inhibition by using a drug called midazolam and found that people got much better at making hard choices. It didn't affect other aspects of their thinking, but rather only the area of making choices. They investigated the effects of decreased inhibition by looking at people with anxiety.

"We found that the worse their anxiety was, the worse they were at making decisions, and the activity in their left ventrolateral prefrontal cortex was less typical," Munakata said.

There are two ways in which the research could be helpful in improving treatments for anxiety, according to Snyder. While specific medications that increase
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Contact: Yuko Munakata
Yuko.Munakata@colorado.edu
303-735-5499
University of Colorado at Boulder
Source:Eurekalert

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