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CTI Focuses on Late-Stage Drug Approvals and Commercialization and Cuts Operating Costs: to Close Bresso Research Center
Date:2/27/2009

xisting portfolio of clinical and preclinical oncology programs. However, at present no alternative solution has been found.

Bresso employees were informed of the company's plans today. The company anticipates starting negotiations with the Trade Unions in the near future.

About Pixantrone

Pixantrone (BBR 2778), a DNA intercalating anti-tumor agent that contains an aza-anthracenedione molecular structure, differentiating it from anthracycline chemotherapy agents, was discovered by our scientists in Bresso, Italy. Pixantrone is a novel DNA major groove binder that contains an aza-anthracenedione molecular structure, differentiating it from anthracycline chemotherapy agents. Anthracyclines have been shown to be very active clinically in a number of tumor types, such as lymphoma, leukemia, and breast cancer. For these diseases, anthracycline-containing chemotherapy regimens are effective in first-line (initial) treatment. However, they may cause cumulative heart damage that limits lifetime dosage and does not allow for retreatment. Pixantrone has been designed to reduce the potential for heart damage compared to currently available anthracyclines or anthracenediones without a loss in anti-tumor or immunomodulatory activities.

In January 2009, CTI announced that pixantrone met its primary endpoint of progression-free survival (PFS), and it expects to begin submission of a rolling NDA and request priority review for pixantrone to treat relapsed aggressive NHL in the first quarter of 2009.

About OPAXIO

CTI currently has one drug for lung cancer, OPAXIO(TM), awaiting approval in Europe. OPAXIO(TM) (paclitaxel poliglumex, CT-2103), which was formerly known as XYOTAX(TM), is an investigational, biologically enhanced, chemotherapeutic that links paclitaxel, the active ingredient in Taxol(R), to a biodegradable polyglutamate polymer, which results in a ne
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SOURCE Cell Therapeutics, Inc.
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