Navigation Links
CTCs predict poor outcome from blood stem cell transplantation therapy for metastatic breast cancer
Date:12/10/2010

SAN ANTONIO Metastatic breast cancer patients who had circulating tumor cells (CTCs) in their blood before or after high-dose chemotherapy (HDCT) followed by autologous stem cell transplantation had poor outcomes, according to researchers from the University of Texas MD Anderson Cancer Center.

Patients with CTCs in their blood before chemotherapy treatment had reduced survival and those with these cells in their blood after the stem cell transplant recurred faster and died earlier. These findings were presented at the 33rd Annual CTRC-AACR San Antonio Breast Cancer Symposium, held Dec 8-12.

While it has been known that CTCs in metastatic breast cancer are linked to cancer recurrence and lower survival, this study adds several new insights, the researchers said. One is that the process of collecting hematopoietic progenitor cells appears to recruit CTCs from bone marrow into the blood, and the other is that these CTCs are likely to be responsible for cancer recurrence.

"Our group had previously shown that metastatic breast cancer patients with CTCs in their blood relapsed faster and now we see that these same cells can be recruited from bone marrow and that they may have the same effect on disease outcome," said the lead researcher Hui Gao, Ph.D., a research scientist working in the laboratory of James M. Reuben, Ph.D.

"Furthermore, some CTCs seem to have the characteristic markings of stem-like cells, but we don't know yet if they are cancer stem cells," Gao said.

The 21 patients included in this study were younger women (average age of 44) diagnosed with metastatic breast cancer who were offered high-dose chemotherapy followed by stem cell transplant. Before chemotherapy, patients were given a growth factor treatment to recruit hematopoietic progenitor cells from bone marrow, then the cells were harvested from their blood.

CTCs were found in six patients before transplant and in nine patients one month after. Researchers determined that more than five CTCs at baseline was associated with shorter overall survival and that five or more CTCs after transplant was linked to both shorter relapse-free survival and overall survival.

The process of using growth factors to mobilize hematopoietic stem cells also appears to mobilize some CTCs that have lost their epithelial properties and undergo mesenchymal transition, according to the researchers. Such cells are not easily detected by the conventional CTC detection assays and the importance of this observation might be overlooked by the clinicians.

High-dose chemotherapy followed by stem cell transplant did reduce the number of existing CTCs in some patients, but increased CTCs in other patients. Patients who recurred faster and had shorter survival had a higher percentage of epithelial cells with stem-like markings mixed in with blood hematopietic progenitor cells that were mobilized by the growth factor to enter blood stream.

"When we enriched for hematopoietic progenitor cells, we found some CTCs within the milieu of cells we collected," Gao said.

In some cases, mobilization may have facilitated the release of cancer stem cells from the bone marrow that were associated with shorter relapse-free survival. However, mobilized CTCs can be removed from the final transplanted product using a procedure to positively select for CD34+ hematopoietic progenitor cells. This procedure may account for the fact that the patients with low CTCs did well.


'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. Early life stress may predict cardiovascular disease
2. SIBLING proteins may predict oral cancer
3. Researchers receive NIH grant to study predictors and outcomes of autoimmune lung disease
4. Fatigue May Predict Heart Attack in Dialysis Patients
5. Predicted Red Tide Could Make Shellfish a Dangerous Dish
6. New tool to predict early death or hospital readmission
7. MSU scientists develop more effective method of predicting lead-poisoning risk
8. Newer Blood Test Predicts Diabetes, Heart Disease
9. Proteins May Predict Spread of Colon Cancer
10. After a fight with a partner, brain activity predicts emotional resiliency
11. Study Predicts Half of Physician Continuing Education Will Be Online by 2016
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... 27, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating to Best ... individuals in the United States and Canada wear eyeglasses. Once considered to be a ... and make a fashion statement. Even celebrities use glasses as a way of creating ...
(Date:6/26/2016)... ... ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop a weight ... app plans to fix the two major problems leading the fitness industry today:, ... program , They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... ... ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize each ... Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into hand ... select a ProHand generator and drag it above media or text in the Final ...
(Date:6/25/2016)... ... 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s ... setting the bar too high can result in disappointment, perhaps even self-loathing. However, those ... goal. , Research from PsychTests.com reveals that behind the tendency to ...
(Date:6/24/2016)... ... 2016 , ... The Pulmonary Hypertension Association (PHA) learned during ... two significant new grants to support its work to advance research and patient ... recognizing patients, medical professionals and scientists for their work in fighting pulmonary hypertension ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 The vast ... an outpatient dialysis facility.  Treatments are usually 3 times ... hours per visit, including travel time, equipment preparation and ... patient, but especially grueling for patients who are elderly ... a skilled nursing and rehabilitation centers for some duration ...
(Date:6/23/2016)... , June 23, 2016  Experian Health, ... and transforming the patient payment and care ... innovative new products and services that will ... revenue cycle offerings. These award-winning solutions will ... workflows, remain compliant in an ever-changing environment ...
(Date:6/23/2016)... WASHINGTON , June 23, 2016  The ... Pharmaceuticals has joined the health policy research organization ... Steven Romano , MD, senior vice president and ... his company,s representative on the NPC Board of ... are pleased that Mallinckrodt has joined us in ...
Breaking Medicine Technology: