Navigation Links
CT shows changes in lungs associated with COPD flare-ups
Date:7/27/2011

OAK BROOK, Ill. (July, 27, 2011) Using computed tomography (CT), researchers have identified two types of structural changes in the lungs of patients with chronic obstructive pulmonary disease (COPD) that are associated with frequent exacerbations, or episodes when symptoms suddenly worsen. Their findings are published online in the journal Radiology.

COPD can damage both the airways and the air sacs of the lungs, and is a leading cause of death and illness worldwide. The two main structural abnormalities seen in COPD are emphysema, in which the air sacs of the lung are gradually destroyed, and airway disease, which causes a narrowing of the bronchial tubes.

"COPD is an extremely common problem that is frustrating to physicians," said the study's lead researcher, MeiLan K. Han, M.D., M.S., assistant professor of medicine at the University of Michigan Health System in Ann Arbor, Mich. "For a long time, we have had a one-size-fits-all approach to treating COPD patients."

COPD is currently staged by measuring lung function with a spirometer, a machine that measures how much air the lungs can hold and how fast air is expelled. A handful of medications are typically prescribed for the condition, regardless of what type of COPD patients have.

"Spirometry is inadequate as the sole parameter for assessing risk of exacerbations," Dr. Han said. "Two COPD patients may be identical in terms of lung function yet behave very differently. For instance, there are subsets of patients with severely reduced lung function who do not experience frequent exacerbations."

According to the National Heart, Lung and Blood Institute (NHLBI), an estimated $49.9 billion was spent on COPD in the United States in 2010, the majority of which was related to exacerbations.

Dr. Han analyzed data from the COPDGene Study, an ongoing multi-center NHLBI-sponsored study, designed to identify genetic factors associated with COPD. In the study, patients who are between 45 and 80 years old with a history of cigarette smoking undergo spirometry and whole-lung volumetric CT examinations.

Dr. Han's study group included the first 2,500 patients enrolled in the COPDGene Study who met criteria for COPD. The researchers studied whether there was an association between a patient's bronchial wall thickness and degree of air sac destruction on CT with frequency of exacerbations.

The analysis revealed that while many patients had a mixture of structural changes related to their COPD, two subgroups predominantly with emphysema or large airway disease could be identified, and both increased airway wall thickness and increased emphysema were associated with greater exacerbation frequency, independent of spirometric measures of lung function.

"Radiologic characterization of COPD patients has prognostic value in the selection of more homogeneous subgroups for clinical trials and possibly for identifying patients at risk of frequent exacerbations for targeted medical therapies," Dr. Han said.

Dr. Han added that her research suggests there may be different disease mechanisms causing inflammation in the two COPD subgroups, and that future studies may help determine if these patients should be treated differently.


'/>"/>

Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America
Source:Eurekalert

Related medicine news :

1. International Poll Shows Many Fear Alzheimers as Much as Cancer
2. New report shows seniors economic security falling
3. Study shows new evidence of age-related decline in the brains master circadian clock
4. Rat Study Shows How Binge Drinking Harms Memory
5. Penn study shows link between immune system suppression and blood vessel formation in tumors
6. Study shows lace-up ankle braces keep athletes on the court
7. TEMLA shows higher diagnostic yield than EBUS or EUS in largest reported series to date
8. Citywide study shows racial disparities in emergency stroke treatment
9. Study shows fast track total hip replacement surgery is effective and safe
10. Group-Think Can Influence Your Memory, Research Shows
11. Lung cancer screening trial shows screening with CT scans reduces lung cancer deaths
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... ... First Choice Emergency Room , the largest network of independent freestanding ... of its new Mesquite-Samuell Farm facility. , “We are pleased to announce Dr. ... James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , Dr. ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson ... Recently, he has implemented orthobiologic procedures as a method for treating his patients. ... the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons ...
(Date:6/25/2016)... Canada (PRWEB) , ... June 25, 2016 , ... Conventional ... pursuit of success. In terms of the latter, setting the bar too high can ... risk more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Those who have ... these feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as ... Michigan, has released tools for healthy coping following a traumatic event. , Trauma sufferers ...
(Date:6/24/2016)... ... 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out of ... verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. ... throw rocks at my other children and say he was going to kill them. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016 Research and Markets has ... Companion Diagnostic Tests" report to their offering. ... Diagnostics The World Market for Companion Diagnostics ... diagnostics. Market analysis in the report includes the following: ... Vitro Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
(Date:6/24/2016)... , Belgium , June 24, ... VNRX), today announced the appointment of Dr. ... Directors as a Non-Executive Director, effective June 23, ... Audit, Compensation and Nominations and Governance Committees.  As ... Futcher will provide independent expertise and strategic counsel ...
(Date:6/23/2016)... Research and Markets has announced the addition of ... report to their offering. ... kidney failure, it replaces the function of kidneys by removing ... thus the treatment helps to keep the patient body,s electrolytes ... Increasing number of ESRD patients & substantial healthcare expenditure ...
Breaking Medicine Technology: