Navigation Links
CT angiography highly accurate, multicenter trials show
Date:11/26/2007

CHICAGO Computed tomography (CT) angiography is as accurate as an invasive angiogram in detecting coronary artery disease, according to the findings of the first two prospective multicenter 64-slice scanner trials presented today at the annual meeting of the Radiological Society of North America (RSNA).

These two trials with comparable results clearly set the stage for the widespread adoption of and reimbursement for coronary artery CT examinations, said Gerald D. Dodd III, M.D., chair of the Department of Radiology at the University of Texas Health Science Center in San Antonio.

For the Coronary Artery Evaluation Using 64-Row Multidetector Computed Tomography Angiography (CORE-64) Trial, researchers at nine international centers studied 291 patients who were scheduled to undergo invasive coronary angiography for suspected or unknown coronary artery disease. The study found that 64-slice multidetector CT angiography was highly accurate in detecting blockages of greater than 50 percent, with a sensitivity of 85 percent and a specificity of 90 percent. The noninvasive exam was equal in accuracy to invasive angiography in its ability to identify patients to be referred for angioplasty or bypass surgery.

Reliable assessment of the presence of coronary blockages and accurate prediction of coronary revascularizations are feasible with 64-slice CT coronary angiography, said presenter Marc Dewey, M.D., radiologist at Humboldt University Berlin, Charit, Germany. Patients with low to intermediate risk of having coronary blockages are most likely to benefit from coronary CT angiography, since in those patients the necessity of invasive angiography is greatly reduced.

The Assessment by Coronary Computed Tomographic Angiography of Individuals UndeRgoing InvAsive Coronary AngiographY (ACCURACY) Trial compared 64-row coronary computed tomographic angiography (CCTA) to quantitative coronary angiography (QCA). The results demonstrated that CCTA is highly accurate in detecting coronary blockages in chest pain patients referred for invasive coronary angiography and is also an effective noninvasive method to exclude obstructive coronary blockages.

Sixteen institutions performed CCTA on 232 patients with typical or atypical chest pain prior to invasive coronary angiography. Findings were then compared to those of QCA, the reference standard used to quantify the results of the invasive coronary angiography.

A total of 82 blockages greater than 50 percent in 49 patients and 31 blockages greater than 70 percent were detected in 28 patients by QCA. Per-patient sensitivity and specificity of CCTA were 93 percent and 82 percent, respectively, for blockages greater than 50 percent, and 91 percent and 84 percent for blockages greater than 70 percent. In addition, negative predictive value was 97 to 99 percent.

In a population of chest pain patients with a low to intermediate prevalence of obstructive coronary artery blockages, CCTA performed highly accurately compared to invasive coronary angiography, said presenter James K. Min, M.D., assistant professor of radiology and medicine at New York Presbyterian Hospital and director of the Cardiac Computed Tomography Laboratory and Cornell University Medical Center. These findings demonstrate the high diagnostic performance of CCTA.


'/>"/>

Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America
Source:Eurekalert

Related medicine news :

1. Catheter angiography may be an unnecessary follow-up to CT angiography
2. Consumer Specialty Products Association Highly Critical of NRDC Study on Home Air Fresheners
3. 454 Sequencing(TM): Science Paper Describes a Novel, Highly Efficient Method of Sequencing Ancient DNA; Sequences the Mitochondria of 10 Individual Mammoths to Prove It
4. 18F-DG PET/CT can highly increase the detection of colorectal cancer
5. Plastic Surgery Complications and Deaths are Rare, Despite Highly Publicized Death of Donda West
6. Medical University of South Carolina Leads Multicenter Study Evaluating Biliary Sphincter Disorder
7. Study Questions Dead-End Cancer Clinical Trials
8. Clinical trials present better alternatives for dialysis patients
9. IMPACT initiative looks to improve patient participation in clinical trials
10. Clinical Trials Directive still hampering academic medical research
11. Oncolytics Biotech Inc. reports positive interim results of UK phase Ia/Ib trials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... New Orleans, LA (PRWEB) , ... December 07, ... ... cosmetic technique used to treat wrinkles and deep lines by smoothing and tightening ... many minimally invasive techniques out there to address facial aging with very little ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... Technology, S.L. (“Presence”) for a purchase price of approximately $17.4 million (net ... Presence’s annual revenue is approximately $13.2 million. Headquartered in Barcelona, Spain, Presence ...
(Date:12/7/2016)... CA (PRWEB) , ... December 07, 2016 , ... Castle ... used in several ways to restore a more youthful appearance to the face. Dr. ... offer Sculptra, along with a variety of other treatments, to rejuvenate and renew the ...
(Date:12/7/2016)... , ... December 07, 2016 , ... They are musicians ... sisters and wives, brothers and fathers, from New England and around the nation. What ... stigma, and are brought together in a beautiful and compelling new photographic exhibit debuting ...
(Date:12/7/2016)... , ... December 07, 2016 , ... ... consultation services from offices located in South Lyon, Dewitt, Williamston, East Lansing, Ann ... basketball coach who needs treatment for a brain tumor. , Jason Bauer and ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... Dec. 7, 2016   IQuity, Inc., a ... Don Hardison has been appointed to ... executive with extensive experience as CEO, COO, and ... 500 companies within the molecular, clinical diagnostic, and ... and sales experience within the pharmaceutical industry. His ...
(Date:12/7/2016)... 2016  Urinary catheters are used for patients ... urological disorders. Urinary catheters include indwelling (Foley) catheter, ... or Foley catheter is a flexible tube with ... is inserted into the bladder through the urethra ... attachment at one end of the catheter is ...
(Date:12/7/2016)... Research and Markets has announced the addition of the "Immunohistochemistry Market ... report to their offering. ... The immunohistochemistry (IHC) market is projected ... 7.3% during the forecast period of 2016 to 2021. ... population across the globe are the primary driving the growth of this ...
Breaking Medicine Technology: