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CT Angiography Highly Accurate: Multicenter Trials Show
Date:11/26/2007

sults demonstrated that CCTA is highly accurate in detecting coronary blockages in chest pain patients referred for invasive coronary angiography and is also an effective noninvasive method to exclude obstructive coronary blockages.

Sixteen institutions performed CCTA on 232 patients with typical or atypical chest pain prior to invasive coronary angiography. Findings were then compared to those of QCA, the reference standard used to quantify the results of the invasive coronary angiography.

A total of 82 blockages greater than 50 percent in 49 patients and 31 blockages greater than 70 percent were detected in 28 patients by QCA. Per-patient sensitivity and specificity of CCTA were 93 percent and 82 percent, respectively, for blockages greater than 50 percent, and 91 percent and 84 percent for blockages greater than 70 percent. In addition, negative predictive value was 97 to 99 percent.

"In a population of chest pain patients with a low to intermediate prevalence of obstructive coronary artery blockages, CCTA performed highly accurately compared to invasive coronary angiography," said presenter James K. Min, M.D., assistant professor of radiology and medicine at New York Presbyterian Hospital and director of the Cardiac Computed Tomography Laboratory and Cornell University Medical Center. "These findings demonstrate the high diagnostic performance of CCTA."

AT A GLANCE

-- Two multicenter trials presented at RSNA2007 have found that CT

angiography is comparable to invasive coronary angiography in detecting

coronary blockages.

-- The CORE-64 Trial evaluated 291 patients at nine international centers

and found that 64-slice multidetector CT angiography was highly

accurate in detecting coronary blockages of greater than 50 percent.

-- The ACCURACY Trial found that noninvasive coronary CT angiography is

highly accurate in detecting coronary blockages in chest pain patients'/>"/>

SOURCE Radiological Society of North America
Copyright©2007 PR Newswire.
All rights reserved

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