Sixteen institutions performed CCTA on 232 patients with typical or atypical chest pain prior to invasive coronary angiography. Findings were then compared to those of QCA, the reference standard used to quantify the results of the invasive coronary angiography.
A total of 82 blockages greater than 50 percent in 49 patients and 31 blockages greater than 70 percent were detected in 28 patients by QCA. Per-patient sensitivity and specificity of CCTA were 93 percent and 82 percent, respectively, for blockages greater than 50 percent, and 91 percent and 84 percent for blockages greater than 70 percent. In addition, negative predictive value was 97 to 99 percent.
"In a population of chest pain patients with a low to intermediate
prevalence of obstructive coronary artery blockages, CCTA performed highly
accurately compared to invasive coronary angiography," said presenter James
K. Min, M.D., assistant professor of radiology and medicine at New York
Presbyterian Hospital and director of the Cardiac Computed Tomography
Laboratory and Cornell University Medical Center. "These findings
demonstrate the high diagnostic performance of CCTA."
AT A GLANCE
-- Two multicenter trials presented at RSNA2007 have found that CT
angiography is comparable to invasive coronary angiography in detecting
-- The CORE-64 Trial evaluated 291 patients at nine international centers
and found that 64-slice multidetector CT angiography was highly
accurate in detecting coronary blockages of greater than 50 percent.
-- The ACCURACY Trial found that noninvasive coronary CT angiography is
highly accurate in detecting coronary blockages in chest pain patients
|SOURCE Radiological Society of North America|
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