Navigation Links
'CSI' technology holds potential in everyday medicine
Date:8/21/2012

PHILADELPHIA, Aug. 21, 2012 A scientific instrument featured on CSI and CSI: Miami for instant fingerprint analysis is forging another life in real-world medicine, helping during brain surgery and ensuring that cancer patients get effective doses of chemotherapy, a scientist said here today.

The report on technology already incorporated into instruments that miniaturize room-size lab instrumentation into devices the size of a shoebox was part of the 244th National Meeting & Exposition of the American Chemical Society, the world's largest scientific society. The meeting, which features about 8,600 reports with an anticipated attendance of 14,000 scientists and others continues here through Thursday.

"With both of the instruments we developed, no sample preparation is needed, which reduces analysis time from as much as several hours per sample to just a few seconds," said Graham Cooks, Ph.D., who led the research team. "Rapid results are critical when a surgeon is operating on a brain tumor or when chemotherapy patients are being treated with powerful drugs that must be administered at precise levels."

The instrument called a "desorption electrospray ionization" mass spectrometer, or DESI, was featured on both CSI and CSI: Miami as a tool to analyze fingerprints. However, this portable instrument can do so much more. It's about the size of a shoebox and does not change or destroy the sample that is analyzed. Cooks' students have even carried it into a grocery store and held it close to the outer surfaces of fruit and vegetables to detect pesticides and microorganisms. The team also used it to identify biomarkers for prostate cancer and to detect melamine, a potentially toxic substance that showed up in infant formulas in China in 2008 and in pet food in the U.S. in 2007. In addition, DESI can detect explosives on luggage.

Now, Cooks' team at Purdue University is teaming up with collaborators led by Nathalie Y. R. Agar, Ph.D., at Harvard University to test the instrument in the operating room during brain cancer surgery, comparing it with the gold standard traditional analysis of tissue samples by pathologists.

"These procedures are among the longest of all surgical operations, and this new technology offers the promise of reducing the time patients are under anesthesia," Cooks explained. "DESI can analyze tissue samples and help determine the type of brain cancer, the stage and the concentration of tumor cells. It also can help surgeons identify the margins of the tumor to assure that they remove as much of the tumor as possible. These are early days, but the analysis looks promising."

The other instrument under development in Cooks' lab is a "PaperSpray ionization" mass spectrometer. The researchers are using this new device to monitor the levels of chemotherapy drugs in patients' blood in real time. "Many cancer drugs have relatively narrow therapeutic ranges, so they need to be in the blood at certain levels to work properly," he noted. "But at present, that information is not obtained in real time, so a patient could end up with too little or too much of the drug in his or her body."

For a video of PaperSpray, click here: http://www.youtube.com/watch?v=BHcMbFyHxTc

Both the DESI and PaperSpray mass spectrometers work in a similar way. To weigh chemicals, mass spectrometers need to ionize, or give a positive or negative charge to a substance. Mass spectrometers usually do this inside the instrument under a vacuum without air. But DESI and PaperSpray can do this so-called ionization process out in the open. This allows scientists much more flexibility. DESI and PaperSpray also can do analyses without separating out all of the chemicals in a sample first (unlike conventional instruments), which provides quick results. They are also very easy to operate. "You just point and shoot," said Cooks.

Currently, Cooks' team is testing to see whether DESI can provide different information compared to what pathologists can provide by looking at human tissues under a microscope. In addition, the researchers are testing PaperSpray on patients' blood samples, though Cooks points out that the device also could measure the levels of drugs of abuse or pharmaceuticals in urine or other body fluids.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
215-418-2056 (Philadelphia Press Center, Aug. 17-23)
202-872-6042

Michael Woods
m_woods@acs.org
215-418-2056 (Philadelphia Press Center, Aug. 17-23)
202-872-6293
American Chemical Society


Source:Eurekalert

Related medicine news :

1. Mechanical tissue resuscitation technology shows promise
2. New study identifies how information technology is used to solve global health challenges
3. Power generation technology based on piezoelectric nanocomposite materials developed by KAIST
4. Simulation technology allows users to safely practice phacoemulsification cataract surgery
5. The Casey Group's Sales Navigator Wins 2012 Best Mobility App in the New Jersey Technology Council's Mobile Application Competition
6. Swanson Health Products Introduces a New Alkalizing Drink Mix, Swanson® pH Balance Alka-Tone with Alka-Plex™ Technology
7. Miami Children’s Hospital Performs First Nerve Repair Surgery Using Avance® Nerve Graft Technology
8. FDA Approves SonixGPS Needle Guidance Technology for Vascular Access Procedures
9. IVR Technology Group Named Platimum VAR by TSYS
10. 3M™ Gripping Material Technology – Giving Golfers a Competitive Edge
11. Newer technology to control blood sugar works better than conventional methods
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... ... January 24, 2017 , ... Element Blue ™, a ... a strategic partnership with Lucidworks , the company transforming the way people ... platform for building powerful enterprise search applications. , Element Blue is a global ...
(Date:1/24/2017)... ... January 24, 2017 , ... Manzo Pharmaceuticals, LLC., announced ... Registered Trademark by the United States Patent and Trademark Office. The purpose ... confuse consumers into thinking that other products are similar to the patented Lacto-Freedom ...
(Date:1/24/2017)... ... January 24, 2017 , ... ... the semi-final round of the 2017 Cupid's Cup Entrepreneurship Competition. Chaired by Under ... year in 2017. The entrepreneurs will showcase their businesses on February 6, 2017, ...
(Date:1/24/2017)... ... January 24, 2017 , ... ... it has officially formed a distribution partnership with Byers Scientific & Manufacturing ... management industry. , Through the agreement, OMI Industries formulated a special version of ...
(Date:1/24/2017)... Rancho Santa Margarita, CA (PRWEB) , ... January 24, 2017 , ... ... career advancement platform for 21st century leadership, has named Hector M. Chavez, Manager, Employee ... cancer and diabetes treatment center - as its Hispanic Leader of the Month. City ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... Market Research Future has a half cooked research report on global ... Surgery & Integumentary System is growing rapidly and expected to reach ... Market Highlights ... Global Plastic Surgery & Integumentary System Market has been evaluated as ... high growth figures and thriving in the coming future. There has ...
(Date:1/24/2017)... -- Analysis of the Liquid Biopsy Market by Sample ... our new study reveals trends, R&D progress, and predicted revenues ... in this sector you must read this brand new report. ... assessing data, trends, opportunities and business prospects there. ... Discover How to Stay Ahead ...
(Date:1/24/2017)... SAN DIEGO , Jan. 24, 2017 /PRNewswire/ ... leader in clinical materials management services, is pleased ... Director of Operations. Kevin joins the Sherpa team ... to the highest level of service excellence. ... supply chain and pharmaceutical manufacturing industries. He has ...
Breaking Medicine Technology: