Navigation Links
CSHL study unmasks a stem cell origin of skin cancer and the genetic roots of malignancy
Date:2/3/2011

Cold Spring Harbor, N.Y. A constellation of different stem cell populations within our skin help it to cope with normal wear and tear. By constantly proliferating, the stem cells allow skin to replenish itself, allowing each cell to be replaced by a new one about once a month. But the normal cycle of division and death within one or more of these stem cell types can sometimes be derailed by genetic mishaps. Such events are believed to spawn carcinomas and other deadly skin cancers, which are the mostly frequently diagnosed cancers in the United States.

Researchers at Cold Spring Harbor Laboratory (CSHL) led by Associate Professor Alea A. Mills, Ph.D., have now unmasked a long sought stem cell origin of carcinoma and identified the genetic lesions occurring within these cells that spur them on to malignancy. Her team has found that increased activity of a powerful oncogene called Ras combined with overly exuberant activity of a protein called ΔNp63α, stimulates the population of skin stem cells that produce keratin 15one of many keratin proteins found in the skinpromoting carcinoma development. These findings appear online on February 4 in the journal Cell Stem Cell.

When cells in the skin or anywhere else in the body sense a potentially cancer-causing threat such as an activated oncogene like Raswhich speeds up cell divisionthe cells cope by slamming on the brakes to trigger a process called senescence. This is a tumor-suppressive mechanism that halts cell division while allowing cells to stay metabolically active.

"Unfortunately there are a number of genetic events that can bypass senescence and push a cell down the road towards cancer," says Mills. The loss of a gene called p53, a powerful tumor suppressor, in senescent cells is one such event.

Mills's group has long focused on p53's sister gene p63, which she discovered during her postdoctoral years. As Mills found subsequently, adult mice that lack p6
'/>"/>

Contact: Hema Bashyam
bashyam@cshl.edu
516-367-6822
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
2. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
3. TV drama can be more persuasive than news program, study finds
4. Study carried out into biological risks of eating reptiles
5. Neuroimaging study may pave way for effective Alzheimers treatments
6. Study finds racial gaps continue in heart disease awareness
7. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
8. First blinded study of venous insufficiency prevalence in MS shows promising results
9. Soothing infants with food focus of childhood obesity study
10. People with anxiety disorder less able to regulate response to negative emotions, study shows
11. American Heart Association Rapid Access Journal Report: Study Finds Racial Gaps Continue in Heart Disease Awareness, Low Knowledge of Heart Attack Warning Signs Among Women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... ERGO-Pedic Products, LLC, which produces therapeutic memory foam ... help a broader range of people plagued by pain. ... most common visitors to doctors. , “The ERGO-Pedic Comfort ... relieve sitting pain. Then, only a couple months after ... later, we began getting questions from those customers, asking ...
(Date:4/17/2015)... April 17, 2015 Florida Hospital Wesley ... and Florida Hospital Carrollwood were all selected as Top ... located in Pasco County, is ranked number one for ... survey, which was conducted in partnership with an independent ... all-private bed hospital that opened in October of 2012 ...
(Date:4/17/2015)... (PRWEB) April 17, 2015 In Defense ... the following statement: “On Wednesday April 15th, the European ... adopted a resolution recognizing the Armenian Genocide, “paying tribute, ... of the one-and-a-half million innocent Armenian victims who perished ... (IDC) extols the EU for this timely and needed ...
(Date:4/17/2015)... Rapids, MI (PRWEB) April 17, 2015 Enthusiasts ... CRUSH Grand Rapids, Saturday, April 25, 2015. The event will ... Reserve Wine & Food (201 Monroe Ave NW, Grand Rapids, ... from around the West Michigan area. Patrons are encouraged to ... of elegance and fun. , This year’s event will feature ...
(Date:4/17/2015)... Most dental patients are not aware that nearly ... by foreign dental laboratories, according to the U.S. International ... than 40 states by their respective state boards of ... has created the “What’s In Your Mouth?” ... consequences that could be associated with using poorly-made dental ...
Breaking Medicine News(10 mins):Health News:Seat Cushion Company Credits Customer Driven Design For Two New Products 2Health News:Tampa Bay Times Selects Florida Hospital Wesley Chapel, Florida Hospital at Connerton Long Term Acute Care and Florida Hospital Carrollwood As Top Workplaces in Tampa Bay 2Health News:Tampa Bay Times Selects Florida Hospital Wesley Chapel, Florida Hospital at Connerton Long Term Acute Care and Florida Hospital Carrollwood As Top Workplaces in Tampa Bay 3Health News:Tampa Bay Times Selects Florida Hospital Wesley Chapel, Florida Hospital at Connerton Long Term Acute Care and Florida Hospital Carrollwood As Top Workplaces in Tampa Bay 4Health News:In Defense of Christians Condemns Armenian Genocide 2Health News:In Defense of Christians Condemns Armenian Genocide 3Health News:Children’s Leukemia Foundation of Michigan Presents 3rd Annual CRUSH Grand Rapids 2Health News:National Association Urges Transparency in Dental Industry 2
... Kids applauds U.S. Senators Arlen Specter and Robert Casey Jr. ... U.S. Food and Drug Administration (FDA) authority to regulate tobacco ... and sales to kids. The U.S. Senate approved the ... similar legislation, and Congress is expected to quickly send a ...
... The Campaign for Tobacco-Free Kids applauds U.S. ... approve historic legislation that gives the U.S. Food and Drug ... to crack down on tobacco marketing and sales to kids. ... 17. The House has approved similar legislation, and Congress ...
... for Tobacco-Free Kids applauds U.S. Senators Carl Levin and Debbie ... the U.S. Food and Drug Administration (FDA) authority to regulate ... marketing and sales to kids. The U.S. Senate approved ... approved similar legislation, and Congress is expected to quickly send ...
... Senators Vote for Historic Bill to Regulate ... The Campaign for Tobacco-Free Kids applauds U.S. Senator Richard ... pass historic legislation that gives the U.S. Food and Drug ... to crack down on tobacco marketing and sales to kids. ...
... for Friday, June 12, 2009 , , LANCASTER, Pa., ... today reported financial results for the third quarter ended May 3, ... thirteen weeks ended May 3, 2009 were approximately $41.8 million, up ... May 4, 2008. , , Income from continuing operations before ...
... , EMERYVILLE, Calif., June 11 Bionovo, Inc. (Nasdaq: ... on June 10, 2009 has denied all claims against the ... , , The decision was in reference to ... Stapleton, alleging fraud, negligent misrepresentation and breach of oral contract ...
Cached Medicine News:Health News:Senators Specter and Casey Vote to Protect America's Kids from Tobacco 2Health News:Senators Murkowski and Begich Vote to Protect America's Kids from Tobacco 2Health News:Senators Levin and Stabenow Vote to Protect America's Kids from Tobacco 2Health News:Senator Durbin Leads Fight to Protect America's Kids from Tobacco 2Health News:Senator Durbin Leads Fight to Protect America's Kids from Tobacco 3Health News:Herley Industries, Inc. Reports Third Quarter Earnings 2Health News:Herley Industries, Inc. Reports Third Quarter Earnings 3Health News:Herley Industries, Inc. Reports Third Quarter Earnings 4Health News:Herley Industries, Inc. Reports Third Quarter Earnings 5Health News:Herley Industries, Inc. Reports Third Quarter Earnings 6Health News:Herley Industries, Inc. Reports Third Quarter Earnings 7Health News:Herley Industries, Inc. Reports Third Quarter Earnings 8Health News:Herley Industries, Inc. Reports Third Quarter Earnings 9Health News:Herley Industries, Inc. Reports Third Quarter Earnings 10Health News:Herley Industries, Inc. Reports Third Quarter Earnings 11Health News:Herley Industries, Inc. Reports Third Quarter Earnings 12Health News:Bionovo Announces Arbitration Decision in Lawsuit Filed by Former Officer - All Claims Denied 2
(Date:4/17/2015)... April 17, 2015 TWi Pharmaceuticals, Inc. ("TWi", ... Pharmaceuticals USA , has obtained state ... States.  It has been in close contact with the ... to have its own label specialty generic products sold ... U.S. pharma market. According to IMS Health, ...
(Date:4/16/2015)... 2015  Hologic, Inc. (NASDAQ: HOLX ) ... i published on-line this week in ... American Cancer Society. The study, by ... Center, supports current consensus guidelines ii for ... years of age be co-tested with both Pap ...
(Date:4/16/2015)... , April 16, 2015 Today, Kenneth ... Merck & Co., Inc., was elected chairman of the Board ... today,s Board meeting, PhRMA,s president and CEO John J. ... 1, 2016.  New Officers Elected to PhRMA ... and succeeds Ian C. Read , chairman and CEO ...
Breaking Medicine Technology:Hologic Comments on Important Cervical Cancer Screening Study Published in the American Cancer Society Journal, Cancer Cytopathology 2Hologic Comments on Important Cervical Cancer Screening Study Published in the American Cancer Society Journal, Cancer Cytopathology 3Hologic Comments on Important Cervical Cancer Screening Study Published in the American Cancer Society Journal, Cancer Cytopathology 4Merck Chairman and CEO Kenneth C. Frazier Becomes PhRMA Board Chairman 2Merck Chairman and CEO Kenneth C. Frazier Becomes PhRMA Board Chairman 3Merck Chairman and CEO Kenneth C. Frazier Becomes PhRMA Board Chairman 4Merck Chairman and CEO Kenneth C. Frazier Becomes PhRMA Board Chairman 5
... Solutions, a global life sciences technology solutions company ... to announce that the company has been named ... year in a row.  The Inc. 5000, an ... magazine, recognizes America,s fastest-growing private companies.   ...
... Genetics, a global leader in genomic services, announced today ... Generation Sequencing System as well as received the first ... been an early adapter of Illumina systems since late ... Provider. A team of scientists routinely process libraries for ...
Cached Medicine Technology:MedNet Solutions Named to the Inc. 5000 List of Fastest Growing Companies for the Fourth Consecutive Year 2Ambry Genetics Announces the Addition of Illumina HiSeq 2000 and First 510(K) Approved BeadXpress® to Its Sequencing and Genotyping Capabilities 2
Colloidal Gold Sol, 40 nm - 50 OD, 1 ml, Gold Sol Nanoparticles - not boiled, not centrifuged...
Colloidal Gold Sol, 40 nm - 12 - 15, 1 ml, Gold Sol Nanoparticles - not boiled, not centrifuged...
Colloidal Gold Sol, 30 nm 12 - 15 OD, 1 ml, Gold Sol Nanoparticles - not boiled, not centrifuged...
Colloidal Gold Sol, 20 nm - 12 - 15 OD, 1 ml, Gold Sol Nanoparticles - not boiled, not centrifuged...
Medicine Products: