Navigation Links
CSHL scientists trace causal link between a tumor suppressor gene and liver cancer
Date:6/3/2008

Scientists at Cold Spring Harbor Laboratory (CSHL) have taken the search for cancer-causing genes an important step forward. In a newly published paper, they confirm that a gene called DLC1 is a tumor suppressor. They have demonstrated in living mice that its deletion, inactivation or loss precipitates events culminating in an aggressive type of liver cancer closely related to common human epithelial cancers of the liver (also known as hepatocellular carcinoma, or HCC).

The team's success in tracing the intricate pathway by which DLC1 functions in both healthy and pathological states suggests a highly specific new target for future anticancer drugs.

Focusing on a Suspected Tumor Suppressor Tumor suppressor genes play a vital role in intracellular signaling networks that protect against uncontrolled cell growth and proliferation. Such genes can be rendered inactive by a variety of DNA alterations, including deletions, mutations and so-called epigenetic changes in DNA's chemical configuration. DLC1 a gene whose acronym reflects prior suspicions that it was "deleted in liver cancer" was known to be located in a region of chromosome 8 that has been observed to be missing in past studies of mammalian liver cancer cells. "The region in question is a large one that may harbor more than one tumor suppressor," said Dr. Scott W. Lowe. "We set out to conclusively identify DLC1 as a tumor suppressor, which had not been done before, and to show at the molecular level how the absence of this gene produces pathology in cells that can lead to liver cancer. Interestingly, loss of DLC1 is observed in a range of epithelial cancers, which suggests that DLC1 may a play common role in many types of human cancer."

In addition to corresponding author Lowe, the research team included five other laboratory heads at CSHL: Prof. Linda Van Aelst, Ph.D., and Prof. Michael Wigler, Ph.D.; Assoc. Prof. Scott Powers, Ph.D.; and Asst. Prof. Robert Lucito, Ph
'/>"/>

Contact: Jim Bono
bono@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/28/2015)... Aliso Viejo, California (PRWEB) February 28, 2015 ... announced the release of a new overlay plugin for Final ... Pixel Film Studios. , “FCPX Overlay Chromatic gives users total ... X,” said Christina Austin, CEO of Pixel Film Studios. “FCPX ... while maintaining an easy to use interface.” , FCPX Overlay ...
(Date:2/28/2015)... The World Scout League Commission (WSLC), an organization ... and firefighters, recently announced its decision to host an ... charitable donations for age-related research. The five-kilometer race, which ... on March 29, 2015; registration will start at 2 ... , To participate in the race, runners have ...
(Date:2/27/2015)... 27, 2015 OnChip Devices , ... introduced miniature, wire bondable, silicon ESD (Electrostatic Discharge) protection ... The ESD88NP and ESD88PN ... sensitive LED and IC products. These Zeners exhibit ... All devices meet the requirements of IEC61000 and ...
(Date:2/27/2015)... 27, 2015 On March 2-4, ... the National Cancer Institute (NCI) will co-host the ... National Institutes of Health (NIH), in Bethesda, Maryland. ... dedicated to medical professionals and scientists who specialize ... the general public, including patients, their families, and ...
(Date:2/27/2015)... 27, 2015 In honor of American Heart Month ... (CPC) South office, is offering tips on how to improve heart ... but that doesn't mean people have to accept it as their ... factors — such as family history, sex or age — there ... Dr. Scott has six helpful tips to improve heart health and ...
Breaking Medicine News(10 mins):Health News:Pixel Film Studios released a new overlay plugin entitled FCPX Overlay Chromatic Grunge 6K exclusively for Final Cut Pro X users 2Health News:Bitcoin Run Is The World Scout League Commission’s Newest Project for Charity 2Health News:OnChip Introduces New Series of Space Saving Bare-die Zener Diodes for Transient Voltage Suppression 2Health News:OnChip Introduces New Series of Space Saving Bare-die Zener Diodes for Transient Voltage Suppression 3Health News:Conference on Mesothelioma Co-Hosted with National Cancer Institute 2Health News:Conference on Mesothelioma Co-Hosted with National Cancer Institute 3Health News:Center for Primary Care Celebrates American Heart Month 2Health News:Center for Primary Care Celebrates American Heart Month 3Health News:Center for Primary Care Celebrates American Heart Month 4
... Community College is striking back - preemptively - against ... National Wear Red Day - Friday, February 6th - to ... death in women. Stickers with the red-dress motif - national ... the entire College community, many of whom also sported red ...
... WEIFANG, Shandong, China, Feb. 12 /PRNewswire-Asia-FirstCall/ -- Shengtai,Pharmaceutical, ... Company"),a leading manufacturer and distributor of high-quality, pharmaceutical ... will issue financial,results for the three months ended ... Friday, February 13, 2009. Management will conduct ...
... Millionaire show the challenges facing the polio eradication initiative ... are getting a short course in polio eradication this ... the status of this paralyzing disease in India and ... has not been stopped. The Final Inch, nominated ...
... University of Houston Center for Drug and Social Policy Research ... National Institutes of Health to study the long-term consequences of ... be awarded over the next four years. , "This ... ago with 160 gang members in west San Antonio," said ...
... and Products to Pamper Tired TootsiesBETHESDA, Md., Feb. 12 ... pampering for countless men and women. While the old adage ... may still hold true, another body part is gaining affection ... Podiatric Medical Association (APMA) survey revealed 84 percent of women ...
... utilize natural surroundings to find peace, rediscover trust ... Feb. 12 Wounded Warrior Project and the ... 16 wounded warriors as part of WWP,s Project ... (PTSD). Project Odyssey brings together veterans with ...
Cached Medicine News:Health News:Bunker Hill Community College Celebrates 'Wear Red Day' 2Health News:Shengtai Pharmaceutical Schedules 2009 Second Quarter Financial Results and Conference Call 2Health News:Shengtai Pharmaceutical Schedules 2009 Second Quarter Financial Results and Conference Call 3Health News:Oscar Nominated Films Raise Polio Awareness 2Health News:Gang researchers at UH examine health, consequences of long-term gang 2Health News:American Podiatric Medical Association Helps Americans 'Love' Their Feet This Valentine's Day 2Health News:American Podiatric Medical Association Helps Americans 'Love' Their Feet This Valentine's Day 3Health News:Wounded Warrior Project's Project Odyssey Aims to Teach Coping Skills for Combating Post-Traumatic Stress in Wounded Warriors 2Health News:Wounded Warrior Project's Project Odyssey Aims to Teach Coping Skills for Combating Post-Traumatic Stress in Wounded Warriors 3
(Date:2/27/2015)... Israel , February 27, 2015 /PRNewswire/ ... baut sein bahnbrechendes Überwachungssystem für kongestive Herzinsuffizienz ... aus -     ... Technologies, die ein neuartiges Herzüberwachungssystem für Patienten ... heute bekannt, dass sie ein Finanzierungsvorhaben über ...
(Date:2/27/2015)... Mass. and JERUSALEM , ... biopharma company developing octreotide capsules, its lead product for ... a $70 million Series E financing round. Participants in ... Sofinnova Ventures, and an undisclosed blue chip public investment ... Capital, 7 Med Health Ventures, Abingworth and ARCH Venture ...
(Date:2/26/2015)... RnRMarketResearch.com adds Corneal Ulcers ... to its store. This report p provides an ... The report "Corneal Ulcers - Pipeline Review, H2 2014" ... Corneal Ulcers. Corneal Ulcers are primarily result of ... infections & fungal infections. The symptoms of the ...
Breaking Medicine Technology:Vectorious Medical Technologies schließt Finanzierungsvorhaben über 5 Mio. USD ab 2Chiasma Announces Completion of $70 Million Series E Financing 2Chiasma Announces Completion of $70 Million Series E Financing 3Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 2Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 3Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 4Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 5
... Idenix Pharmaceuticals, Inc. (NASDAQ: IDIX ), announced today ... Jefferies 2011 Global Healthcare Conference on June 9, 2011 at ... live and archived webcast of the company presentation can be ... at www.idenix.com . Please log in approximately 5-10 minutes ...
... CLEVELAND, May 26, 2011 Within3, a leading provider ... organizations, today announced it will participate in five industry ... Program Management, Social Media Regulations and Compliance, Digital Pharma ... Summit. Said Mr. Hill, "As a consequence ...
Cached Medicine Technology:Within3 To Participate in Key Industry Events 2Within3 To Participate in Key Industry Events 3
This table has a rectangular top, adjustable height, integral leg, and rail clamp.,Standard 2" (5 cm) pad included....
This table has adjustable height, square post and adjustable leg. Includes clamps, and standard 1" (2.5 cm) pad....
... The onboard rail clamps ... O.R. tables and stretchers. ... any need for lifting. ... a stable surface combined ...
The DHS Basic Set is available with either self-tapping or non-self-tapping screws. Either instrument set provides complete instrumentation in one graphic case for use with the Universal Implant Set,...
Medicine Products: