Navigation Links
CSHL scientists show how a protein that determines cell polarity prevents breast cancer
Date:11/26/2008

i.e., present in abnormal quantity, in human breast cancer. Myc is known to activate pathways of both growth and death in breast epithelial cells. In fact, the only way that cancer can occur when Myc is overexpressed is if some other mechanism blocks its propensity to induce abnormal cells to commit suicide, a process called apoptosis. Muthuswamy and colleagues now identify this "other mechanism" as the loss of the Scribble protein, which thus is revealed to be a tumor suppressor protein.

Cells engineered by the CSHL team to lack Scribble and overexpress Myc not only stayed alive, but also went into a growth overdrive. The combined effect of polarity loss and Myc overactivation was the formation of unusually large and fast-growing breast epithelial tumors.

The CSHL team worked out the molecular players and specific intracellular pathway controlled by Scribble to initiate cell death. This revealed that Scribble only works as a cancer deflector when it finds itself in the right location--within the junctions between cells. Cellular disorientation occurs when mutations in the gene that orders Scribble to be produced in a cell either prevents its expression or causes it to be expressed in the wrong location within the cell. In either case, the same severe consequence ensues: cancer progression.

How Scribble gets deregulated in cancer remains a mystery. The CSHL team is now addressing the question of how the deregulated Scribble pathway can be targeted for diagnosis and treatment.


'/>"/>

Contact: Hema Bashyam
bashyam@cshl.edu
516-367-6822
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Europe is one of the largest ... hence, irrigated land area. The agricultural sector is a ... around 30.0% of the total water use. The scale ... southern region, but far from negligible in most northern ... over 60.0% of the water use in most countries, ...
(Date:7/11/2014)... are insoluble colorants, which usually consist of inorganic compounds. ... and coloring. These are water and oil insoluble natural ... as paper, paints, plastics, and concrete. Binders are used ... to the substance. Some examples of pigments are titanium ... coloring action of pigments is due to the scattering ...
(Date:7/11/2014)... best available treatment for patients, from a range of ... taxpayers than the existing clinical trial process, a new ... out while he was a member of the Clinical ... at The University of Manchester,s Health eResearch Centre, published ... today (Friday 11 July) looked at the use of ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 Experience Mayan ... Mayan Heritage Experience Package at the luxury all-inclusive AAA ... package include a guided on-site ecological family tour where ... as The Coba Mayan Encounter Tour at the Mayan ... Muul, the tallest pyramid in the Yucatan and the ...
(Date:7/11/2014)... 2014 WWTrek Human Outreach Project ... Community in Tanzania. Opened in 2012, the KKC is now ... cows. HOP Founder, Dean Cardinale, started the KKC to create ... orphaned children he encountered while running treks on Tanzania's Mount ... who have all made astounding progress in school over the ...
Breaking Medicine News(10 mins):Health News:Europe Micro Irrigation System Market Driven by Growing Environmental Concerns and Decreasing Water Availability - New Report by MicroMarket Monitor 2Health News:Europe Micro Irrigation System Market Driven by Growing Environmental Concerns and Decreasing Water Availability - New Report by MicroMarket Monitor 3Health News:Americas Pigments Market Worth 1,099 Thousand MT by 2018 - New Report by MicroMarket Monitor 2Health News:Americas Pigments Market Worth 1,099 Thousand MT by 2018 - New Report by MicroMarket Monitor 3Health News:Better use of electronic health records makes clinical trials less expensive 2Health News:Explore the Aura and Mystery of the Yucatan’s Mayan Culture with New Hotel Package at AAA Five Diamond Grand Velas Riviera Maya 2Health News:Explore the Aura and Mystery of the Yucatan’s Mayan Culture with New Hotel Package at AAA Five Diamond Grand Velas Riviera Maya 3Health News:Human Outreach Project Sees Incredible Progress in the Kilimanjaro Kids Community 2
... scientists, led by researchers at the University of California, San ... for a condition in which eye and brain development is ... potential remedy that would involve a simple, daily dietary supplement. ... of glycosylation or CDG, a group of syndromes in which ...
... By Amanda Gardner HealthDay Reporter , WEDNESDAY, ... does raise the risk of heart attack more than other ... with tightened controls, a U.S. government advisory panel recommended late ... panel of experts rejected the option that the U.S. Food ...
... from the American Cancer Society and other world-leading health ... whose potential to cause cancer is as yet unresolved. ... research, and to lead to well-planned epidemiologic or mechanistic ... The report, "Identification of research needs to resolve ...
... University researchers and African colleagues will be studying strategies ... and environmental health. The work in regions where the ... a $2.2 million, four-year grant from the U.S. National ... 24 villages in the Mvomero district of Tanzania to ...
... Winston Salem, N.C. New research accepted by the ... developed at Wake Forest University will slash years off the ... treatments to patients much more quickly. Lab-on-Bead uses ... a disease marker in a single step, so researchers can ...
... fight as soldiers in 86 countries across the globe, ... explored how these children adjust after they return to ... was the characteristics of the communities to which the ... that former child soldiers from Sierra Leone who lived ...
Cached Medicine News:Health News:UC San Diego researchers find cause of metabolic disease -- and possible cure 2Health News:UC San Diego researchers find cause of metabolic disease -- and possible cure 3Health News:Avandia Raises Heart Risk But Should Stay on Market, FDA Panel Finds 2Health News:Avandia Raises Heart Risk But Should Stay on Market, FDA Panel Finds 3Health News:Avandia Raises Heart Risk But Should Stay on Market, FDA Panel Finds 4Health News:Report outlines knowledge gaps for 20 suspected carcinogens 2Health News:Duke and African partners to study sustainable malaria control 2Health News:Researchers cut years from drug development with nanoscopic bead technology 2Health News:Studies explore effects of war on former child soldiers 2Health News:Studies explore effects of war on former child soldiers 3Health News:Studies explore effects of war on former child soldiers 4
(Date:7/10/2014)... JORDAN, Utah , July 10, 2014  BC ... solutions, and MiE America , Inc., a leading ... have entered into a long-term agreement naming BC Technical ... the US. MiE and BC Technical ... strategic agreement to establish BC Technical as the service ...
(Date:7/10/2014)... -- CVS Caremark Corporation (NYSE: CVS ) today ... dividend of $0.275 (27.5 cents) per share on the corporation,s ... to holders of record on July 21, 2014. ... to helping people on their path to better health as ... States . Through the company,s more than 7,600 CVS/pharmacy ...
(Date:1/15/2014)... DUBLIN , Jan. 15, 2014  Research and Markets ... "Dental Consumables Market - Global Industry Analysis, Size, ... report to their offering. (Logo: ... products which are used on patients in order to ...
Breaking Medicine Technology:BC Technical Partners With MiE America To Be Authorized Provider Of Systems & Service 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 3
... SUNNYVALE, Calif. , June 3 Accuray ... the field of radiosurgery, today announced the installation of the ... of its acceptance as the world,s leading device for radiosurgery. ... in the United Kingdom , the first hospital operated ...
... , June 3 Perrigo Company (Nasdaq: PRGO ... the U.S. Food and Drug Administration for its abbreviated new drug ... generic to Monistat® -1 Combination Pack. Perrigo expects to begin shipping ... , ...
Cached Medicine Technology:Accuray Installs 200th CyberKnife Robotic Radiosurgery System 2Accuray Installs 200th CyberKnife Robotic Radiosurgery System 3Accuray Installs 200th CyberKnife Robotic Radiosurgery System 4Accuray Installs 200th CyberKnife Robotic Radiosurgery System 5Perrigo Announces FDA Final Approval for Miconazole 2Perrigo Announces FDA Final Approval for Miconazole 3
A budget-priced microscope designed for ENT and neuro surgery....
... has pioneered the development of ... system, an innovative solution that ... efficient and less invasive. The ... the OME-7000 surgical microscope, the ...
... Leica M501 TTS offers the comfort of ... and training application. The microscope offers brilliant ... stereopsis and natural color reproduction. A separate ... can be optimized with a special jalousie ...
The Leica M500 OH3 is an advanced surgical microscope used by neurosurgeons. It is a smart system combining the best optical performance available on the market with an innovative and unique stand....
Medicine Products: