Navigation Links
CSHL scientists identify a new strategy for interfering with a potent cancer-causing gene
Date:2/11/2013

earchers were able to decrease leukemia cell proliferation in living mice, extending their lifespan.

Upon closer examination, the team realized that by targeting RNF20 they prevent MLL-fusion proteins from being able to work. "When we reduce the levels of RNF20 in leukemia cells, they revert back to being more like normal blood cells", says Shinpei Kawaoka, a postdoc in the Vakoc lab who also was involved in the study.

Vakoc's team proposes a model in which leukemia cells of the MLL-rearranged subtype come to rely on RNF20 to maintain their gene expression program, implicating it as a potential therapeutic target. Small-molecule drugs that target other proteins involved in regulating ubiquitin tags already exist so it is possible that drugs targeting RNF20 could be developed in the future for the treatment of MLL-rearranged leukemia.


'/>"/>
Contact: Edward Brydon
ebrydon@cshl.edu
516-367-6822
Cold Spring Harbor Laboratory
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Scientists solving the mystery of human consciousness
2. Scientists uncover multiple faces of deadly breast cancer
3. Scientists identify major source of cells defense against oxidative stress
4. Scientists tailor cell surface targeting system to hit organelle ZIP codes
5. Scientists rewrite rulebook on breast cancer in landmark global study
6. Warwick scientists uncover how checkpoint proteins bind chromosomes
7. NIH scientists link quickly spreading gene to Asian MRSA epidemic
8. Joslin scientists identify important mechanism that affects the aging process
9. Scripps Research scientists show how memory B cells stay in class to fight different infections
10. Scientists Map Melanomas Genome
11. A*STAR scientists discover switch to boost anti-viral response to fight infectious diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2013)... May 25, 2013 Communities of Distinction ... It is the fifth largest media market in the United ... number one visitor destination in Texas and a major convention ... the American West as it is home to many major ... enjoy from sports to the arts. Residents and locals will ...
(Date:5/25/2013)... 25, 2013 Actos lawsuit ... U.S. District Court, Western District of Louisiana, continue to ... a Case Management Order issued on May 21st, the ... contested motions in the Actos bladder cancer litigation, as ... Actos Product Liability Litigation, MDL No. 2299) , “We ...
(Date:5/25/2013)... great companions for senior citizens, but elderly people who always ... likely to crash than those who never drive with a ... licensed drivers aged 70 and older. The nearly 700 participants ... their pet in the car. Among those who always ... high as among those who never drove with their pet. ...
(Date:5/25/2013)... United States (PRWEB) May 25, 2013 ... and largest underground shelter company in the US ... composite underground structures for over 35 years. M.E. ... PROTECTION, U.S. Handbook of NBC Weapon Fundamentals and ... the United States’ bible on shelter engineering. McCarthy ...
(Date:5/25/2013)... 25, 2013 Providing patients with their best ... team of weight management professionals. But, aside from educating patients ... Diet Doc’s hCG diets also provide patients, who ... childhood like bullying, more control over their lives by achieving ... with the underlying factors of weight gain derived from earlier ...
Breaking Medicine News(10 mins):Health News:Communities of Distinction TV Presents May Air Dates for Dallas-Ft. Worth, Texas 2Health News:Actos Lawsuit News: Bernstein Liebhard LLP Notes New Case Management Order in Federal Actos Bladder Cancer Litigation 2Health News:Actos Lawsuit News: Bernstein Liebhard LLP Notes New Case Management Order in Federal Actos Bladder Cancer Litigation 3Health News:Seniors More Likely to Crash When Driving With Pet: Study 2Health News:Radius Engineering International Inc. Offers Tools to Stay Safe and Recover From Any Disaster 2Health News:Radius Engineering International Inc. Offers Tools to Stay Safe and Recover From Any Disaster 3Health News:hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Announces hCG Diet Plans for Those Suffering from Abuse-Related Weight Gain 2Health News:hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Announces hCG Diet Plans for Those Suffering from Abuse-Related Weight Gain 3
... something that Dr. David Williams has been questioning since 1992. , ... ... PSA test -- in both predicting cancer and saving lives -- was ... Times. The reliability of this test is something that Dr. David ...
... Sisters take on nursing medical malpractice challenge by ... Their Product RNReport card introduces standardized shift reporting ... organized in their day to day tasks.RNReport Card ... and shift reporting process. It fits conveniently in ...
... tool aimed at rapid employee development of on-the-job performance. Human ... accelerate their development. RapidEcho provides an evidence based method for ... for personal improvement. , ... Sydney, ...
... therapy to decrease testosterone levels increase their risk of ... who do not take these medications, according to a ... of CANCER , a peer-reviewed journal of the ... and careful scrutiny of patients, health can keep men ...
... LINTHICUM, MD, April 27, 2009The American Urological Association (AUA) ... recent recommendations issued by other major groups about ... test should be offered to well-informed, men aged 40 ... at least 10 years. The PSA test, as well ...
... cutting services and staff, while more patients are in ... out of ten hospitals nationally are seeing a greater ... departments, according to a new survey from the American ... half of hospitals reported they have cut staff. ...
Cached Medicine News:Health News:Dr. David Williams Scoops National Media on PSA Effectiveness -- by 17 Years 2Health News:RN Sisters Bring Low-Tech Innovations to New Nurses and Nursing Students 2Health News:PeopleStreme Releases RapidEcho Online Tool for Employee Personal Development 2Health News:PeopleStreme Releases RapidEcho Online Tool for Employee Personal Development 3Health News:Prostate cancer therapy increases risk of fractures and cardiovascular-related death 2Health News:AUA counters mainstream recommendations with new best practice statement on PSA testing 2Health News:AUA counters mainstream recommendations with new best practice statement on PSA testing 3Health News:AUA counters mainstream recommendations with new best practice statement on PSA testing 4Health News:Economic Downturn Taking Toll on Patients and Communities Hospitals Serve: New Survey Finds 2Health News:Economic Downturn Taking Toll on Patients and Communities Hospitals Serve: New Survey Finds 3
(Date:5/24/2013)... -- Auxilium Pharmaceuticals, Inc. (Nasdaq: AUXL ) today ... Bank Health Care Conference to be held May 29-30 ... Adrian Adams , Chief Executive Officer and President, ... and its product pipeline at 12:00 p.m. ET on ... http://photos.prnewswire.com/prnh/20101202/MM10881LOGO ) The presentation will also be ...
(Date:5/24/2013)... , May 24, 2013  Sinovac Biotech ... provider of biopharmaceutical products in China ... operating subsidiary company of Sinovac, obtained the Certificate ... Certificate) from the China State and Food Administration ... bulk production plants, and its Changping filing and ...
(Date:5/24/2013)... GARDEN CITY, England and ... Heptares Therapeutics, the leading GPCR drug discovery and development company, is ... Usui as a Consultant to augment the Company,s business ... territories. Mr Usui has more than 15 years of ... industry including senior roles at Perlegen Sciences, Inc., Roche Pharma ( ...
Breaking Medicine Technology:Auxilium Pharmaceuticals, Inc. To Present At The Deutsche Bank Health Care Conference 2Auxilium Pharmaceuticals, Inc. To Present At The Deutsche Bank Health Care Conference 3Auxilium Pharmaceuticals, Inc. To Present At The Deutsche Bank Health Care Conference 4Sinovac Beijing Obtains China GMP Certificate Under the New GMP Guidelines 2Sinovac Beijing Obtains China GMP Certificate Under the New GMP Guidelines 3Heptares Augments Business Development Capabilities in Japan and Other Asian Territories 2
... Announces Preliminary Top-Line Positive Data from taliglucerase alfa Switchover Trial -- CARMIEL, Israel, Nov. 2, 2010 ... ... if (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; --> ... var shortURL = ""; BitlyCB.alertResponse = function(data) { var s = ,; var first_result; // Results are keyed by ...
... Nov. 1, 2010 More than half of the ... Fund portfolio have received notices of funding through the ... Protection and Affordable Care Act of 2010. ... FAST, GRest, Pericardial Access and SonarMed all learned today ...
Cached Medicine Technology:Protalix BioTherapeutics Announces Preliminary Top-Line Positive Data from taliglucerase alfa Switchover Trial 2Protalix BioTherapeutics Announces Preliminary Top-Line Positive Data from taliglucerase alfa Switchover Trial 3Protalix BioTherapeutics Announces Preliminary Top-Line Positive Data from taliglucerase alfa Switchover Trial 4Protalix BioTherapeutics Announces Preliminary Top-Line Positive Data from taliglucerase alfa Switchover Trial 5Protalix BioTherapeutics Announces Preliminary Top-Line Positive Data from taliglucerase alfa Switchover Trial 6Protalix BioTherapeutics Announces Preliminary Top-Line Positive Data from taliglucerase alfa Switchover Trial 7Protalix BioTherapeutics Announces Preliminary Top-Line Positive Data from taliglucerase alfa Switchover Trial 8Protalix BioTherapeutics Announces Preliminary Top-Line Positive Data from taliglucerase alfa Switchover Trial 9Protalix BioTherapeutics Announces Preliminary Top-Line Positive Data from taliglucerase alfa Switchover Trial 10Indiana Life Sciences Start Ups Garner More than $1.5 Million in Competitive Federal Funding 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: