Navigation Links
CSHL scientists discover new details of a gene-regulatory network governing metabolism
Date:2/22/2008

Cold Spring Harbor, NY Metabolism is a central feature of life a myriad of biochemical processes that, together, enable organisms to nourish and sustain themselves. Scientists at Cold Spring Harbor Laboratory (CSHL) are in the forefront of efforts to demonstrate how the regulation of genes governs fundamental life processes, including metabolism.

Such research, performed on simple model organisms like yeast cells, has implications for efforts to understand natural processes such as aging and disease states including cancer.

This week a team at CSHL led by Professor Leemor Joshua-Tor, Ph.D., announced a new and unexpected wrinkle in a story they previously thought they understood about how yeast cells, through the action of genes, adjust their metabolism in response to changes in their sources of food. The teams findings were published February 22 in the journal Science.

Adapting to New Energy Sources

S. cerevisiae, or common bakers yeast, can use any number of different types of sugar molecules for energy production, noted Dr. Joshua-Tor, a structural biologist. Importantly, the yeast cell can rapidly respond to changes in its nutritional environment by altering the expression of specific genes that allow it to make use of those different energy sources.

This much, notes Dr. Joshua-Tor and colleagues, has been understood for years. The players involved in this process have been known for some time. But we did not understand precisely how the components of this particular biochemical pathway worked together, said Stephen Johnston, a professor at the Biodesign Institute at Arizona State University and a co-author of the study.

It was Dr. Joshua-Tors team at CSHL that took the step of investigating the architecture of the proteins involved in the pathway, at the level of individual atoms. Using a technique called x-ray crystallography, they discovered a player in the molecular cast of characters whose involvement previously had been overlooked.

The unexpected molecule is called NADP. The team discovered that when a yeast cell changes from using glucose, a simple sugar, as a nutritional source to using galactose, a more complex sugar often found in dairy products and vegetables such as sugar beets, NADP is called into action. It docks to a protein called Gal80p, which acts along with a gene regulating-protein called Gal4p, to adapt the metabolism of the yeast cell so that it can make use of galactose.

Importantly, changes in cellular levels of NAD, a close relative of NADP, had previously been linked to a gene circuit that controls aging and longevity in a large number of different organisms, including yeast but also including animals, said Professor Rolf Sternglanz of Stony Brook University in New York, a co-author of the study.

Why The Regulatory Cascade Is Important

It is becoming increasingly clear that the metabolic state of a cell is linked to the expression of its genes in a way that impacts biological processes of many kinds, ranging from cancer to aging, said Dr. Joshua-Tor. The biochemical cascade identified by the team is part of a complex chain of events whose object is regulation of the output of specific genes.

Not only does the teams work help explain how links in that gene-regulatory chain are constructed. Gene-regulatory proteins impact every property of a cell and have long been recognized as possible targets for drugs, said Dr. Joshua-Tor. However, these types of proteins have proven resistant to the chemistry of modern drug design. A detailed understanding of how gene regulatory proteins are controlled may offer new and unanticipated opportunities to design drugs that would impact this class of proteins.


'/>"/>

Contact: Jim Bono
bono@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert  

Related medicine news :

1. Scientists make first map of emerging-disease hotpsots
2. Scientists shed light on long-distance signaling in developing neurons
3. Scientists explore consciousness
4. Scientists using laser light to detect potential diseases via breath samples, says new study
5. Scientists move towards stem cell therapy trials to mend shattered bones
6. U-M scientists develop tool to probe role of oxidative stress in aging, disease
7. Scientists Show Stem Cells Dont Cause Cancer
8. Microbial cheaters help scientists ID social genes
9. Scientists solve structure of gene regulator that plays key role in cancer
10. VEGF Neutralization Can Damage Brain Vessels, Say Schepens Eye Research Institute Scientists
11. VEGF neutralization can damage brain vessels, say Schepens Eye Research Institute scientists
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
CSHL scientists discover new details of a gene-regulatory network governing metabolism
(Date:2/24/2017)... Prior Lake MN (PRWEB) , ... February 24, ... ... the launch of its newly designed TaskMate Go. Core benefits and advantages built ... grain finish and a stylish, functional look and feel. Ability to gain the ...
(Date:2/24/2017)... ... February 24, 2017 , ... An in-depth computational analysis ... University of Pittsburgh points to eight genes that may explain why susceptibility to one ... the results of a study published today in the journal npj Schizophrenia. , ...
(Date:2/24/2017)... ... February 24, 2017 , ... With ... is so critically important that we all are aware of our options and ... is proud to announce the launch of its newest edition of "Vision and ...
(Date:2/24/2017)... ... February 24, 2017 , ... The California State University Institute ... faculty engaged in or interested in palliative care education and research. The Symposium, ... in North County San Diego on Sept. 28 and 29, 2017, on the campus ...
(Date:2/24/2017)... ... ... The Radiology Business Management Association will select the 2017 ... Building Better Radiology Marketing Programs conference, held this year from March 5 to ... are given out in five categories. They are:, ,     Patient Marketing, ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... Research and Markets has announced the addition of ... to their offering. ... latest research Hemophilia Drugs Price Analysis and Strategies - 2016, provides drug ... answers the following questions: What are the ... positioned in the Global Hemophilia market? What are the ...
(Date:2/24/2017)... -- Physician General Dr. Rachel Levine and ... Smith commended South Central EMS today for their ... a life-saving overdose reversal drug. The recognition event also ... overdose survivor who was saved due to the administration ... part of fighting the opioid epidemic is making sure ...
(Date:2/24/2017)... HILL, N.C. , Feb. 24, 2017 /PRNewswire/ ... are exploring ways to increase their self-service capabilities ... Health Care Providers (HCPs). New research ... many pharma organizations have developed self-service website portals ... electronically.  This is just one of many findings ...
Breaking Medicine Technology: