Navigation Links
CSHL scientists discover link between control of chromosome duplication and segregation
Date:2/5/2009

Cold Spring Harbor, N.Y. Before a cell can divide into two, first it must duplicate its genetic material--the DNA packed in its chromosomes. The two new sets of chromosomes then have to be separated from one another and correctly distributed to the resulting "daughter" cells, so that both daughter cells are genetically identical to the original, or "parent," cell.

During cell division, a cellular organ called the centrosome, and a copy of the centrosome, position themselves at opposite ends of the dividing cell. Each centrosome serves as an anchor for a spindle, a complex structure of filament-like tubules that radiates out from each centrosome and connects with special sites called centromeres on the chromosomes. By pulling on the chromosomes, the spindles separate them into two sets, each divided equally into the two emerging daughter cells.

It's crucial that cells duplicate their centrosome only once during each division cycle. Extra copies can result in incorrect distribution of chromosomes, which can lead to genomic instability and cancer. Hence the importance of new research by Professor Bruce Stillman, Ph.D., and his lab group at Cold Spring Harbor Laboratory (CSHL). They have identified a protein molecule that controls the copying of the centrosome in human cells and prevents it from being re-duplicated. Their findings will appear in the February 6th issue of the journal Science.

Double duty for Orc1

The molecule shown by Dr. Stillman and his colleagues to control centrosome duplication is Orc1, one of six proteins that comprise the Origin Recognition Complex. ORC, as it is called, is an assembly that attaches to particular sequences within all the DNA in the cell and prepares it for duplication. Recently it had become clear that some ORC proteins might be doing more than jump-starting DNA duplication; the accumulation of extra centrosome copies in cells that lack ORC suggested that some or all
'/>"/>

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. UCSB scientists make headway in understanding Alzheimers disease
2. Spanish scientists confirm extra virgin olive oil helps to combat breast cancer
3. UCLA scientists develop crystal ball for personalized cancer treatment
4. Weizmann Institute scientists create working artificial nerve networks
5. Scientists unmask genetic markers associated with psoriasis
6. Scientists and Investigators Cite Need for Radon Regulation to Prevent Lung Cancer- Call Current EPA Efforts Ineffective
7. Slices of living brain tissue are helping scientists identify new stroke therapies
8. Federal Members of Advisory Committee Block Vaccine-Autism Research, Defy Wishes of Its Own Scientists, Autism Community, and Congress
9. Canada-US scientists discover gene responsible for brains aging
10. University of Ottawa Heart Institute Scientists Successfully Develop Novel Biomaterial to Help Grow New Blood Vessels
11. Scientists develop new tool to improve oral hygiene
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2015)... On March 19, 2015, at ... Lions wide receiver Herman Moore, hosted “Fighting Addiction ... substance abuse, treatment options and the recent changes ... pastors, ministers and bishops from local churches as ... , “Our ‘Fighting Addiction Together’ luncheon was informative ...
(Date:3/27/2015)... 2015 GenSight, the leading Enterprise Portfolio ... Fitzgerald, a former technology and financial executive to serve ... Chief Financial Officer. , Mr Fitzgerald was most recently ... backed by Amazon founder and CEO Jeff Bezos, Google ... to EverFi, he was a Senior Vice President at ...
(Date:3/27/2015)... WA (PRWEB) March 27, 2015 When ... can be hard to know where to begin. The ... experienced Seattle trucking accident attorney, offers accident victims a ... and legal assistance to ensure their personal injury claim ... begins by describing the first actions that should be ...
(Date:3/27/2015)... St. Paul, MN (PRWEB) March 27, 2015 ... first annual Minnesotans for Healthy Kids Coalition Lobby ... and the Statewide Health Improvement Program (SHIP). ... for the 2015 PE Bill SF343/HF498 which would ... benchmarks, require annual student assessments and other measures ...
(Date:3/27/2015)... Ontario (PRWEB) March 27, 2015 ... in the safe prescribing and utilization of medical ... joined Canada.MarijuanaDoctors.com’s network of doctors and clinics dedicated ... , MarijuanaDoctors.com, a trusted gateway for patients searching ... states and territories, recently launched their sub domain ...
Breaking Medicine News(10 mins):Health News:LiveToBeSober.org Hosts Conference on Substance Abuse Treatment and Recovery at Ford Field 2Health News:GenSight Appoints Former Technology Executive as Chief Operating Officer 2Health News:Dax Jones Updated eBook on Trucking Accidents Offers Helpful Information to Crash Victims 2Health News:Everlast Climbing Advocates to Strengthen Physical Education in Minnesota Schools 2Health News:Canadian Cannabis Clinics (CCC) to Join the Canada.MarijuanaDoctors.com Network 2
... made heart implanted inside him last month .This makes ... beat! ,“Heartmate II”, the mechanical heart was implanted inside ... a three-hour surgery on Nov. 23, 2006.This device,is expected to function ... balanced within a magnetic field. Before the surgery, the patient was ...
... difficulty making ends meet and most often end up selling ... study included 1,751 people.// ,People diagnosed with ... report to work regularly and at the same time face ... selling their homes. ,The Macmillan Cancer Support ...
... are not protected from attacks or stroke by taking a ... ,Folic acid or folate is one of the B Vitamins ... medical practitioners prescribe it to prevent cardiac problems. ... Health and Tropical Medicine, New Orleans led a research on ...
... causes cervical cancer as it affects the lining of the ... sexually.// ,Merck & Co. Inc.'s have recently launched ... been proven to prevent cervical cancer. ,The new ... rich countries but it is very doubtful how it would ...
... ,Long shifts done by doctors in the hospitals results// ... rested and well-trained doctors. ,An U.S study by ... working long shifts without rest have an increased risk (300 ... could be prevented. ,The study was based ...
... Deafness Research UK has suggested that certain Christmas toys are ... when 14 toys out of the 15 that// were tested, ... prescribed safety limits of 85 decibels. ,Among ... which included a mechanical toy machine gun, a plastic tommy ...
Cached Medicine News:Health News:Vaccines For Cervical Cancer Will Soon Be Available In Developing Nations 2Health News:Toy Story Turns Bitter-Christmas Toys, No Music to the Ears! 2
(Date:3/27/2015)... 2015 Zimmer Holdings, Inc. (NYSE and SIX: ZMH) is celebrating ... Complete Knee System. , ... year since Zimmer first introduced the NexGen knee system, with ... than five million implantations of the NexGen knee have taken ... NexGen knee demonstrates the importance of design innovation and component quality ...
(Date:3/27/2015)... 2015 XRpro Sciences, Inc., a provider ... development services which features high throughput transporter and ... financial results for the year ended December 31, ... of XRpro Sciences commented, "We have completed a ... stage to commercial stage in large part by ...
(Date:3/27/2015)... 27, 2015 Report Details  ... ophthalmic drug companies  What does the future ... industry ? Visiongain,s brand new report shows you potential ... there. Our 242-page report provides 185 tables, ... the industry and the future market prospects. Our new ...
Breaking Medicine Technology:Zimmer Celebrates Key Milestones For NexGen Complete Knee System 2XRpro Sciences Announces Fiscal 2014 Financial Results 2XRpro Sciences Announces Fiscal 2014 Financial Results 3XRpro Sciences Announces Fiscal 2014 Financial Results 4Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 2Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 3Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 4Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 5Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 6Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 7
... Breast-Specific Gamma Imaging (BSGI) has been proven to be a ... in situ (DCIS), a difficult to diagnose breast cancer. BSGI ... independent of tissue density and discover very early stage cancers. ... the Radiological Society of North America (RSNA), BSGI is an ...
... , , TORONTO, Nov. 30 The Special ... "Company") (TSX: PTI) and JLL Partners, Inc. and its affiliate, ... Company and JLL have entered into a settlement agreement in ... , The settlement provides among other things that: , ...
Cached Medicine Technology:Breast-Specific Gamma Imaging Proves Highly Sensitive for the Detection of Ductal Carcinoma In Situ 2Patheon and JLL Partners Announce Litigation Settlement 2Patheon and JLL Partners Announce Litigation Settlement 3
... built to be the best stress treadmill ... quieter and more reliable than any competitor, ... safety and comfort of the patient. It ... features include a low profile deck, incredibly ...
... digitally-controlled drive system which eliminates many ... wear out. There are no motor ... fewer drive belts - resulting in ... can carry weights up to 400 ...
... PCE PC-Based Exercise ECG Systems offer clinical ... provide advanced database functionality for paperless storage. ... the Welch Allyn PCE Exercise ECG software ... test system. And with its ability to ...
... systems feature our internationally-acclaimed algorithm that ... algorithm has a proven record for ... situations; and it's just one of ... recognized market leader in the stress ...
Medicine Products: