Navigation Links
CSHL scientists discover how a tumor suppressor induces senescence and staves off cancer
Date:4/13/2010

p>

The team found that when RB alone was switched off, the cells could not efficiently undergo this process of oncogene-induced senescence. When these cells lost RB activity, they could not shut off DNA replication, began to replicate out of control and developed genomic instability. "These aberrant processes, when exacerbated by breakdowns in other control mechanisms, lead to the development of malignant tumors," says Agustin Chicas, Ph.D., a postdoctoral fellow working with Dr. Lowe and the lead investigator in the study.

Further investigations showed that a key target of RB is a gene called cyclin E1, which has been found to be overactive in many human tumors and is often associated with poor prognosis in patients. Its normal function is to spur DNA replication during the cell cycle and hence it is tightly suppressed by RB in senescent cells. The team showed that the loss of RB frees cyclin E1, thus allowing cells to escape senescence.

"Our team's findings suggest that the selective targeting of DNA replication genes during senescence represents one key activity of RB in tumor suppression," says Lowe.


'/>"/>

Contact: Hema Bashyam
bashyam@cshl.edu
516-367-6822
Cold Spring Harbor Laboratory
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Scientists ID a protein that splices and dices genes
2. Breakthrough by Danish scientists in preventing maternal malaria
3. NIH scientists identify maternal and fetal genes that increase preterm birth risk
4. UM School of Medicine scientists find new malaria vaccine is safe and protective in children
5. Gladstone scientists identify target that may reduce complications of obesity
6. Scientists map out regulatory regions of genome, hot spots for diabetes genes
7. Doctors and Scientists Create New Society to Promote Non-Animal Toxicology Testing Methods
8. Scientists discover enzyme that cleans cancer cells
9. Scientists Decode Brain Cancer Cell Line
10. Scientists show how molecular switch helps pancreatic cancer beat drugs
11. Brain scientists extend map of fear memory formation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... Myers, FL (PRWEB) May 23, 2013 On ... prediction in the midst of growing numbers of H7N9 cases ... UV-Aid, Predict H7N9 Bird Flu Cases Will Subside in Northern ... May 13th no new cases have been reported. , ... the flu is as predictable as flowers budding in the ...
(Date:5/23/2013)... 23 (HealthDay News) -- Schools should ensure that ... activity each day to support their health and ... report. Although previous studies show 60 ... health and development, it,s estimated that only about ... this recommendation, according to the report from the ...
(Date:5/23/2013)... (HealthDay News) -- A shortage of a critical tuberculosis ... the United States to contain the spread of the ... drug, isoniazid (INH), was first used in 1951 and ... core of any first-line treatment for tuberculosis (TB). Patients ... according to the U.S. Centers for Disease Control and ...
(Date:5/23/2013)... 2013 Special Learning, Inc., a ... resources for the autism, Down syndrome and special ... its first global autism treatment center and Special ... This new world-class program is the first of ... practices to treat and deliver exceptional education outcomes ...
(Date:5/23/2013)... May 23, 2013 Applied PilotFish ... today that it has added support for the Direct ... the eiConsole for Healthcare. In addition to the product’s ... LLP, FTP, and Web Services, it now offers support ... Protocol is a specification of the Direct Project ...
Breaking Medicine News(10 mins):Health News:UV Technologies Bold Prediction on H7N9 in China Comes True, New Cases End Without Aid of Flu Vaccine 2Health News:UV Technologies Bold Prediction on H7N9 in China Comes True, New Cases End Without Aid of Flu Vaccine 3Health News:U.S. School Kids Should Get Hour of Exercise Daily: Report 2Health News:Shortage of Key Drug Hampering U.S. Efforts to Control TB: Report 2Health News:Special Learning, Inc. to Expand its Services for Individuals with Special Needs with Opening of New Special Education School in the Philippines 2Health News:Special Learning, Inc. to Expand its Services for Individuals with Special Needs with Opening of New Special Education School in the Philippines 3Health News:PilotFish Expand’s Healthcare Integration Capabilities with Support for the New Direct Protocol in Its Latest Product Release 2
... health system echoes that of many caregivers , , MONDAY, ... to care for her gravely ill husband, journalist and ... moment. , More than a year ago, her husband, ... York City rehabilitation facility after spending several months there ...
... to California, The Beryl,Companies has begun providing post-discharge ... about patients, experiences within 72 hours,of an inpatient ... of this new service are BroMenn Healthcare System ... CA; HealthONE in Denver; Henry,Mayo Newhall Memorial Hospital ...
... HLTH ) announced today that it has commenced its ... stock at a price per share,of $8.80. The number of ... 43% of HLTH,s currently outstanding shares. The,last reported sales price ... Market on October 24, 2008 was $8.06 per share., ...
... Calif., Oct. 27 Accuray,Incorporated (Nasdaq: ARAY ), ... that its management is scheduled to present at the ... November,4, 2008 at 10:00 a.m. EST (7:00 a.m. PST.), ... available online from the,investor relations page of the Company,s ...
... Oct. 27 Authentidate,Holding Corp. (Nasdaq: ... workflow,management software and web-based services, today announced ... has implemented Authentidate,s,Inscrybe Healthcare service to more ... customer base in both Ohio and New ...
... no gastrointestinal, side effects for people who need the ... ... Oct. 27 Announced today at the American,Dietetic Association, ... both heme (protein-based iron) and non-heme,iron (plant-based iron) will ...
Cached Medicine News:Health News:Caring for Aging Loved Ones Can Be a Catch-22 2Health News:Caring for Aging Loved Ones Can Be a Catch-22 3Health News:Caring for Aging Loved Ones Can Be a Catch-22 4Health News:Caring for Aging Loved Ones Can Be a Catch-22 5Health News:The Beryl Companies Launches CARE Calls Program in Five Hospitals Across U.S. 2Health News:HLTH Corporation Announces Commencement of Its Tender Offer 2Health News:HLTH Corporation Announces Commencement of Its Tender Offer 3Health News:HLTH Corporation Announces Commencement of Its Tender Offer 4Health News:Accuray Incorporated to Speak at Oppenheimer Healthcare Conference 2Health News:WILLCARE Chooses Authentidate's Inscrybe(TM) Healthcare Service to Streamline Operations and Enhance Business Growth 2Health News:WILLCARE Chooses Authentidate's Inscrybe(TM) Healthcare Service to Streamline Operations and Enhance Business Growth 3Health News:WILLCARE Chooses Authentidate's Inscrybe(TM) Healthcare Service to Streamline Operations and Enhance Business Growth 4Health News:First-Ever Over-the-Counter Dual Action Iron Supplement Launched at the American Dietetic Association Conference in Chicago; Bifera to be Available in Select Stores in Early 2009 2
(Date:5/23/2013)... SAN DIEGO , May 23, 2013 /PRNewswire/ ... the prostate cancer treatment continuum was highlighted prominently ... the American Urological Association (AUA), in San Diego.  ... invasive high intensity focused ultrasound (HIFU) technology, the ... localize disease, and for urologists to consider minimally ...
(Date:5/23/2013)... May 23, 2013  Hologic, Inc. (Hologic or ... leading developer, manufacturer and supplier of premium diagnostics, ... emphasis on serving the healthcare needs of women, ... in a U.S. clinical practice comparing breast cancer ... with conventional 2D mammography alone showed a significant ...
(Date:5/23/2013)... ALBUQUERQUE, N.M. , May 23, 2013  Net ... in the telemedicine market, announced today the company has ... a telemedicine staffing company based in Huntsville, ... agency that specializes in the staffing and recruitment of ... upon completion of the final agreement, which is expected ...
Breaking Medicine Technology:Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 2Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 3Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 4Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 5Need for Image Guided Minimally Invasive Ablative Treatments Featured Prominently at American Urological Association (AUA) Annual Meeting 6First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 2First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 3First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 4Net Medical Xpress Announces Acquisition of Telemedicine Staffing Company 2Net Medical Xpress Announces Acquisition of Telemedicine Staffing Company 3
... that a new market research report is available in ... Drugs, Markets and Companies ... concepts of pathomechanisms of pain as a basis for ... segments of the pain market are arthritis, neuropathic pain ...
... superDimension, Ltd. ® , a privately-owned company that develops ... received FDA 510(k) clearance for the superDimension marker delivery ... Company,s Electromagnetic Navigational Bronchoscopy (ENB) system, which has treated ... David S. Wilson, MD, Columbus Regional Hospital, ...
Cached Medicine Technology:Reportlinker Adds Pain Therapeutics - Drugs, Markets and Companies 2Reportlinker Adds Pain Therapeutics - Drugs, Markets and Companies 3superDimension Receives FDA 510(k) Clearance for Marker Delivery Kit 2superDimension Receives FDA 510(k) Clearance for Marker Delivery Kit 3superDimension Receives FDA 510(k) Clearance for Marker Delivery Kit 4
... technology has allowed for perfecting mini-invasive endoscopic ... various pathologies with a considerable social impact. ... reducing the post-operatory times and represents a ... in all hospital structures.,DEKAs family of Nd:YAG ...
... facial skin treatment, vascular treatment, ... Incorporates a wide range of ... hand pieces and large spot ... most flexibility. Compact table-top ...
... removal for all skin types, ... for leg and facial veins, ... a large spot sizes with ... treatment. An optional scanner ...
... 435 is a full system for hair removal, ... up a complete hair reduction system. The ... heating of the hair bulb and bugle. To ... distributed to the tissue through the MedArt® 413 ...
Medicine Products: