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CROI -- Day 2: Selected highlights of NIH-supported research
Date:2/28/2011

The 18th Conference on Retroviruses and Opportunistic Infections is taking place at the Hynes Convention Center in Boston from February 27 through March 2. Day two of this major HIV/AIDS research conference included the following selected presentations from scientists supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

HIV/TB Co-Infection

Diane Havlir, M.D., of the University of California, San Francisco School of Medicine, presented findings from an international clinical trial known as ACTG 5221, or STRIDE, in persons co-infected with HIV and tuberculosis (TB). The study compared the risks and benefits of immediate versus early antiretroviral therapy (ART) in HIV-infected patients being treated for TB. The findings further illuminate the delicate balance of starting HIV treatment in individuals who also have TB, as HIV treatment in this context can sometimes cause a severe immune inflammatory syndrome. For HIV/TB co-infected patients who have fewer than 250 CD4+ T cells per cubic millimeter (mm3), the researchers found that beginning ART within 2 weeks (immediate) after beginning TB treatment does not reduce the risk of AIDS or death compared with starting ART 8 to 12 weeks later (early). However, in the subset of individuals with fewer than 50 CD4+ T cells/mm3a state of severe immune system damagestarting ART within 2 weeks after beginning TB treatment reduces the risk of AIDS or death significantly.

Microbicide Research

Peter Anton, M.D., of the David Geffen School of Medicine at the University of California, Los Angeles, presented findings from the Phase I clinical trial known as RMP-02/MTN-006, a placebo-controlled study comparing rectally applied 1% tenofovir gel to oral tenofovir disoproxil fumarate. In an earlier landmark study, tenofovir gel protected 39 percent of female participants from HIV infection when applied vaginally. In fi
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Contact: Laura Sivitz Leifman
niaidnews@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

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