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CPF, PFF, and ATS announce new research grant for pulmonary fibrosis research
Date:3/20/2013

and activation of M2s obtained from patients with IPF.

  • Beiyun Zhou, PhD, assistant professor of medicine, of the University of South California's Division of Pulmonary & Critical Care, for her study "Endoplasmic Reticulum (ER) Stress Induces Epithelial-Mesenchymal Transition (EMT) in Alveolar Idiopathic Pulmonary Fibrosis." The researcher is investigating the hypothesis that ER stress induces EMT in epithelial cells thereby contributing directly to fibrosis. Understanding the mechanisms whereby ER stress contributes directly to fibroblast accumulation in IPF should provide new insights into the causes of pulmonary fibrosis that may in turn offer novel therapeutic strategies for this otherwise fatal disease.

  • Philip Simonian, MD, assistant professor of Pulmonary Sciences & Critical Care at the University of Colorado Denver, for his study "Protection from Inflammation-Induced Pulmonary Fibrosis by IL-22." The focus of the research is to determine the mechanism by which IL-22 protects against lung fibrosis so that better therapies can be developed that protect patients from the development of pulmonary fibrosis.

  • Jia Guo, MD, MS, of the University of Rochester for his study "Fibrocyte Differentiation is Regulated by Yin Yang 1 in Pulmonary Fibrosis." His research team has discovered that a protein called yin yang 1 (YY1) regulates the activity of genes involved in promoting the scarring process and can regulate the production and accumulation of myofibroblasts in lung scarring. The ultimate goal of the research is to develop therapies to interfere with the functions of YY1 as a novel treatment for idiopathic pulmonary fibrosis and other lung scarring diseases.

  • Yan Sanders, MD, MS, of the University of Alabama at Birmingham for her study "Epigenetic Regulation of Caveolin-1 by TGF-beta Mediated Signal Pathway in Lung Fibroblasts." Completion of this study will establish epigenetic regulation as one important factor in the pathogenesis
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  • Contact: Nathaniel Dunford
    ndunford@thoracic.org
    American Thoracic Society
    Source:Eurekalert

    Page: 1 2 3 4 5

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