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CPF, PFF, and ATS announce new research grant for pulmonary fibrosis research
Date:3/20/2013

on in Idiopathic Pulmonary Fibrosis (IPF)." The study's purpose was to determine whether the loss of the expression of miR-17~92 (microRNA) cluster contributes to the pathogenesis of pulmonary fibrosis. PFF/ATS Partnership Awards through 2012 were granted to:

  • Anne Holland, PhD, of La Trobe University, for her study "Where Does Pulmonary Rehabilitation Fit in the Management of Pulmonary Fibrosis?" This study will provide patients and doctors with certainty regarding the role and timing of pulmonary rehabilitation in IPF, ensuring best possible outcomes in quality of life and community functioning.

  • Anthony Shum, MD of the University of California, San Francisco, for his study "Defining the Molecular Basis of Interstitial Lung Disease in Rheumatoid Arthritis." Dr. Shum will take advantage of an exciting new technology called exome sequencing to identify the genes that trigger ILD in rheumatoid arthritis patients. Awarded by the CPF/PFF/ATS Partnership beginning 2009 were:

  • Steven Huang, MD, lecturer, University of Michigan Medical School, for his study "The Regulation and Pattern of the DNA Methylome in Pulmonary Fibrosis." The study involves hypermethylation of DNA, an epigenetic process recognized to be important in many diseases though understudied in IPF and genes that may be hypermethylated, and to profile the DNA methylome of fibrotic lung fibroblasts. Also, his study addresses how prostaglandin E2, an antifibrotic lipid mediator, may be able to regulate DNA methylation machinery.

  • Erica Herzog, MD, PhD, of Yale University's Division of Pulmonary and Critical Care Medicine, for her study "Semaphorin 7a and Alternative Macrophage Activation in Idiopathic Pulmonary Fibrosis." The research seeks to determine the mechanism through which semaphorin 7a promotes the appearance of M2s and collagen deposition in a mouse model of pulmonary fibrosis and to determine the mechanism through which semaphorin 7a affects the differentiation
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  • Contact: Nathaniel Dunford
    ndunford@thoracic.org
    American Thoracic Society
    Source:Eurekalert

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