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CPAP rapidly improves blood pressure and arterial tone in adults with sleep apnea
Date:6/2/2014

DARIEN, IL A new study suggests that continuous positive airway pressure (CPAP) therapy rapidly improves blood pressure and arterial tone in adults with obstructive sleep apnea (OSA).

Results show that there was a significant reduction in systolic and diastolic blood pressures among sleep apnea patients who were compliant with CPAP therapy for three months. Successful treatment of sleep apnea also was associated with decreased vascular tone and arterial stiffness. Following one week of treatment withdrawal, these improvements disappeared and reverted to baseline values.

"We were surprised by the very rapid improvements in arterial tone, seen as early as four weeks into treatment, and how quickly they reversed after only a few days of treatment withdrawal," said principal investigator Claudia Korcarz, DVM, RDCS, manager and senior scientist at the University of Wisconsin Atherosclerosis Imaging Research Program (UW AIRP) in Madison. "We noticed these improvements in young, normotensive subjects. These findings demonstrate that the vascular effects of sleep apnea are reversible if treated early in the disease process, suggesting that we might be able to mitigate the long-term risk of chronic exposure to OSA."

The research abstract was published recently in an online supplement of the journal Sleep and will be presented Wednesday, June 4, in Minneapolis, Minnesota, at SLEEP 2014, the 28th annual meeting of the Associated Professional Sleep Societies LLC.

The study group comprised 47 adults with a mean age of about 41 years who had been recently diagnosed with OSA. They were evaluated before and after three months of CPAP therapy, as well as one week after treatment withdrawal. Carotid to radial artery pulse wave velocity and central aortic blood pressures were obtained by applanation tonometry. Brachial artery size and flow-mediated dilation were measured with B-mode ultrasound.

Subjects were considered to
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Contact: Lynn Celmer
lcelmer@aasmnet.org
630-737-9700
American Academy of Sleep Medicine
Source:Eurekalert

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