Navigation Links
CPAP decreases cardiovascular mortality in elderly patients
Date:5/15/2011

ATS 2011, DENVER Continuous positive airway pressure (CPAP) effectively decreases the risk of cardiovascular death in elderly patients who suffer from obstructive sleep apnea (OSA), according to a study conducted by researchers in Spain. The study is the first large-scale study to assess the impact of OSA and the effectiveness of CPAP treatment in cardiovascular mortality in the elderly.

The findings will be presented at the ATS 2011 International Conference in Denver.

"Our study offers two key conclusions," said Miguel Angel Martinez-Garcia, MD, study lead author pneumonologist at the Hospital General de Requena in Valencia, Spain."First, with younger patients, elderly patients with severe, untreated sleep apnea have a higher cardiovascular mortality than those with mild to moderate disease or those without sleep apnea; and second, treatment with CPAP can reduce cardiovascular mortality in elderly OSA patients to levels similar to those found in patients without disease or with mild to moderate sleep apnea."

Millions of people worldwide suffer from sleep apnea, which has been associated with cardiovascular health risks and poorer quality of life. Most studies, however, have been conducted in younger populations, Dr. Martnez-Garca noted.

"CPAP has been shown to be a very effective treatment for severe and symptomatic forms of sleep apnea," he said. "However, virtually all studies on the effectiveness of CPAP to date have been conducted in middle-aged individuals, despite the fact that a growing percentage of the patients we see in our sleep units are elderly and are treated with CPAP.

"This is a very important issue considering the gradual increase in longevity worldwide," he added.

Patients with severe OSA typically experience regular interruptions in their sleep when breathing temporarily stops. In these patients, normal airflow is blocked as the soft tissue of the airway collapse and sag into the throat, preventing normal respiration. In CPAP, pressurized air is delivered continuously through a mask worn over the nose or nose and mouth to help keep the soft tissues of the airway from collapsing.

For their study, Dr. Martnez-Garca and colleagues enrolled 939 elderly patients referred with suspected sleep apnea between 1999 and 2007, and followed these patients through 2009. Patients were divided into four groups: a control group without OSA; mild to moderate OSA patients without CPAP treatment; patients with severe OSA without CPAP treatment; and patients with any degree of OSA who received CPAP treatment. Complete health histories, including cardiovascular and respiratory data, were obtained from all patients at enrolment and mortality causes were obtained from death certificates. Fatal cardiovascular events included sudden death, stroke, heart failure (HF), cardiac arrhythmias and ischemic heart disease (IHD). Median follow-up time was 69 months.

The researchers found that untreated severe OSA (but not untreated mild-moderate OSA) was independently associated with all-cause and cardiovascular mortality, as well as stroke and HF mortality, but not with IHD mortality. In addition, they found that CPAP treatment reduced these increased risks of mortality in OSA patients.

Dr. Martnez-Garca said the results were not entirely unexpected, since anecdotal evidence and several smaller studies have indicated CPAP offers improved outcomes in certain patients, notably patients at risk for stroke.

"Our study provides an excellent scientific basisfor further studies in this area given a lack of scientific evidence on the impact of sleep apnea and the role of CPAP treatment in elderly patients," Dr. Martnez-Garca said. "These findings clearly support the fact that treatment with CPAP is effective in elderly people and therefore, within logical limits, it must be a treatment that is offered to patients with severe or symptomatic OSA regardless of their age.

"The next step is to assess the effect of CPAP treatment in elderly OSA patients in large, randomized clinical trials," he added. "These studies should explore not only cardiovascular outcomes, but other outcomes such as neurocognitive dysfunction."


'/>"/>

Contact: Keely Savoie
ksavoie@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Animal-assisted therapy decreases patient anxiety in pre-MRI setting, study suggests
2. Prenatal exposure to common insecticide linked to decreases in cognitive functioning at age 7
3. Study shows attendance at state parks grows, even as funding decreases
4. Prevalence of heavy smokers in US decreases
5. HBV infection decreases risk of liver metastasis in colorectal cancer patients
6. Targeted therapy decreases progression rate in thyroid cancer
7. Inhibiting fatty acids in immune cells decreases atherosclerosis risk
8. Physical therapist-led exercise in patients in ICU improves function and decreases hospital stay
9. Simple reduction technique decreases radiation dose associated with CT scans of the head
10. Number of Children in Foster Care Decreases but Critical Needs Go Unmet
11. Severe sleep apnea decreases frequency of nightmare recall
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... ... 2016 , ... Amada Senior Care, premier provider of non-medical in-home care and ... San Antonio West location. Prior to entering the senior care industry, Amada franchise partner ... Amada San Antonio West will take place on Friday, April 29th. , ...
(Date:4/28/2016)... ... April 28, 2016 , ... Point Source ... microphones and headsets announced today that the US Patent Office has approved its ... a structure. This innovative design creates a lightweight and modular audio headset that ...
(Date:4/28/2016)... Tamarac, FL (PRWEB) , ... April 28, 2016 , ... ... body recovery supplement GlycoLoad at this week’s 2016 Europa Games Get Fit and ... health conscious consumers alike, the Europa Orlando Expo coming up April 29-30, was selected ...
(Date:4/28/2016)... Washington, D.C. (PRWEB) , ... April 28, 2016 , ... ... Control and Prevention (CDC) has established an ICD-10-CM code for sarcopenia, giving it recognition ... by the medical community effective October 1, 2016. , Sarcopenia is defined as a ...
(Date:4/28/2016)... ... April 28, 2016 , ... ... health insurance co-operative bankruptcy to receive their prescription medications through America’s fastest-growing ... FDA-approved prescription medications from over 180 American pharmaceutical companies for $35 per ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... , April 27, 2016  Bayer Animal ... a senior from the University of Florida College ... the Bayer Excellence in Communication Award (BECA). Brittany ... which were awarded a total of $70,000 in ... last four years, Bayer has provided a total ...
(Date:4/27/2016)... Global  urinalysis market  is ... 2022, according to a new report by Grand ... http://photos.prnewswire.com/prnh/20150105/723757 ) , Automation is ... accuracy delivered by the new generation urinalysis devices ... instruments and consumables. For instance, the automatic bench-top ...
(Date:4/26/2016)... Holdings, Inc. (NYSE: HRC ) invites you to ... st Annual Health Care Conference on Wednesday, May 4, ... to listen to the live discussion via the internet link ... http://edge.media-server.com/m/p/mr4uxgas . A recorded replay of the discussion will be ... accessible at the links above until August 1, 2016. ...
Breaking Medicine Technology: