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COX-2 expression is marker for cancer development in some benign breast biopsies
Date:3/11/2008

east biopsy; and some of them receive the worrisome news that they have atypical hyperplasia, Dr. Hartmann says. If other studies validate these findings, she notes that one strategy to help manage patients may be to use a COX-2 inhibiting agent, such as celecoxib (http://en.wikipedia.org/wiki/Celecoxib)or rofecoxib (http://en.wikipedia.org/wiki/Rofecoxib), to prevent breast cancer from developing. This study raises the possibility of targeting COX-2 in selected women to reduce their risk of breast cancer, she says.

In the biopsy profile thus far, the Mayo risk model includes age, the number of regions of atypical cells in the biopsy, COX-2 expression and the status of the normal lobules in the breast.

Our goal is to individualize risk for breast cancer so that we can provide effective care and risk reduction for each of our patients, says Dr. Hartmann.

Cyxlooxygenase (COX) enzymes produce prostaglandin compounds responsible for pain and inflammation, and nonsteroidal anti-inflammatory drugs (NSAIDs) are designed to reduce expression of COX enzymes, although some NSAID use has been associated with side effects (most notably possible kidney failure). COX-2 is a form of COX that is not usually found in normal tissues but which has been associated with several cancers, including ductal carcinoma in situ and invasive breast cancers.

In this study, researchers examined breast biopsy samples that contained atypia for COX-2 expression which has never been done before.

Investigators looked at 235 women who had a breast biopsy following a mammogram at Mayo Clinic from 1967 through 1991, and who were diagnosed with the atypical hyperplasia cell growth disorder.

During an average follow-up period of 15 years, 41 (17 percent) of the women developed breast cancer. The average time for that breast cancer to be diagnosed wa
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Contact: Russ Vanderboom
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

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