Navigation Links
COPD increases risk of developing cerebral microbleeds
Date:7/18/2013

Chronic obstructive pulmonary disease (COPD) is associated with an increased risk of developing cerebral microbleeds, according to a new study from researchers in the Netherlands. Cerebral microbleeds are a marker of cerebral small vessel disease, an important cause of age-related disability and cognitive decline.

"The connection between COPD and cerebral small vessel disease was suggested by two earlier studies, but the connection between COPD and cerebral microbleeds, the location of which can help elucidate underlying disease mechanisms, has not been studied," said researchers Lies Lahousse, PhD, of the Department of Respiratory Medicine at Ghent University Hospital in Belgium and Bruno Stricker, PhD, of the Department of Epidemiology at Erasmus Medical Center in Rotterdam, the Netherlands. "In the current study, we found, for the first time, that COPD increases the risk of cerebral microbleeds in deep or infratentorial brain regions, not only in a cross-sectional analysis but also in a longitudinal analysis in subjects without microbleeds at baseline."

Microbleeds in deep (deep gray matter of the basal ganglia and thalamus and white matter of the corpus callosum, internal, external, and extreme capsule) or infratentorial (brainstem and cerebellum) locations are suggestive of hypertensive or arteriosclerotic disease in the small blood vessels. The prevalence of large vessel disease is known to be increased in COPD, and these new results "indicate that COPD might affect both large and small vessels," said Dr. Lahousse.

The findings were published online ahead of print publication in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

The study included 165 subjects with COPD and 645 subjects with normal lung function from the Rotterdam study, a prospective population-based cohort study in subjects ≥55 years. COPD diagnoses were confirmed by spirometry and cerebral microbleeds were detected with high-resolution MRI.

Compared with subjects with normal lung function, COPD patients had a significantly higher prevalence of cerebral microbleeds, which was independent of age, sex, smoking status, atherosclerotic large vessel disease, antithrombotic use, total cholesterol, triglycerides, and serum creatinin levels. The prevalence of microbleeds in deep or infratentorial locations was also significantly increased in COPD patients and the prevalence of these microbleeds increased with increasing severity of airflow limitation.

In a longitudinal analysis restricted to subjects without microbleed at baseline, COPD independently predicted incident cerebral microbleeds in deep or infratentorial locations.

The study had some limitations, including the cross-sectional design of the main analysis and the association of COPD with multiple comorbidities, some of which may affect cerebral small vessel disease.

"We have shown that COPD is associated with an increased risk of developing cerebral microbleeds in deep or infratentorial locations," said Dr. Lahousse. "Given the potential cognitive and functional consequences of these microbleeds, preventive strategies for vulnerable patients need to be developed."


'/>"/>

Contact: Nathaniel Dunford
ndunford@thoracic.org
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Risk of Coronary Disease Increases Every Year Someone is Obese
2. As Demand for PPACA Information Increases, United Benefit Advisors Names Chief Compliance Officer, Linda Rowings, “Staff Member of the Year”
3. TPA Continues to Keep Annual Employee Benefit Cost Increases to a Minimum without Sacrificing the Level of Quality
4. Growth in cerebral aneurysms increases risk of rupture
5. Pre-pregnancy diabetes increases risk of MRSA among new mothers
6. Exposure to BPA in developing prostate increases risk of later cancer
7. Childbirth increases risk of ACPA-negative rheumatoid arthritis
8. The Kravis Children’s Hospital at Mount Sinai Increases Number of Specialties Ranked in U.S. News & World Report “Best Children’s Hospitals”
9. Botox Popularity Increases With 20-Somethings
10. Dimension One Spa Filter Distributor, Easy Spa Parts, Increases Inventory of Factory Authorized Filters to Meet Demand and Eliminate Quality Issues
11. Child maltreatment increases risk of adult obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... ... April 28, 2016 , ... Sanford ... this week. A group of researchers and leaders from Sanford Health were selected ... Medicine and Its Cultural Impact ” and receive the 2016 Pontifical Key Innovation ...
(Date:4/28/2016)... ... April 28, 2016 , ... Head Over Heels Athletic Arts’ gymnast, ... The competition will be held at the University of Montana on April 28-May 1. ... the Mississippi River. , In order to qualify, Varize needed to place top seven ...
(Date:4/28/2016)... Angeles, CA (PRWEB) , ... April 28, 2016 , ... ... on its website, cosmetictown.com . The forum section was recently revamped and upgraded ... the latest surgical techniques in use across the country. , According to the senior ...
(Date:4/28/2016)... ... April 28, 2016 , ... In 2011, TIME magazine named ... emerging field of biomechatronics, technology that marries human physiology with electromechanics. He continues that ... is also the Founder of BionX , a leader in the field of ...
(Date:4/28/2016)... ... April 28, 2016 , ... One way to ignore ... This is unfortunately true. But we toss the baby out with the bathwater when ... provides tips for identifying higher-quality studies and otherwise making better use of education policy ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... -- TapImmune,Inc. (TPIV), a clinical-stage immune-oncology ... immunotherapeutics and vaccines for the treatment of cancer & metastatic ... Annual Growth Capital Expo to be held on May ... Palace in Las Vegas, Nevada.  The Company presentation will ... by Dr. John N. Bonfiglio a TapImmune ...
(Date:4/27/2016)... Inc. (Nasdaq: HOLX ) announced today ... quarter ended March 26, 2016.  GAAP diluted earnings ... non-GAAP diluted EPS of $0.47 increased 14.6%.  Revenue ... basis, and 6.3% on a constant currency basis.  ... highlighted by 14.6% growth in non-GAAP EPS," said ...
(Date:4/27/2016)... 2016   ... sur le trimestre, soutenu par une croissance de ... Croissance de +16% des ventes aux hôpitaux et ... Technologies (Euronext : MKEA, FR0010609263 ; OTCQX : MKEAY), inventeur de ... son chiffre d,affaires pour le premier trimestre clos ...
Breaking Medicine Technology: