Navigation Links
COPD increases risk of developing cerebral microbleeds
Date:7/18/2013

Chronic obstructive pulmonary disease (COPD) is associated with an increased risk of developing cerebral microbleeds, according to a new study from researchers in the Netherlands. Cerebral microbleeds are a marker of cerebral small vessel disease, an important cause of age-related disability and cognitive decline.

"The connection between COPD and cerebral small vessel disease was suggested by two earlier studies, but the connection between COPD and cerebral microbleeds, the location of which can help elucidate underlying disease mechanisms, has not been studied," said researchers Lies Lahousse, PhD, of the Department of Respiratory Medicine at Ghent University Hospital in Belgium and Bruno Stricker, PhD, of the Department of Epidemiology at Erasmus Medical Center in Rotterdam, the Netherlands. "In the current study, we found, for the first time, that COPD increases the risk of cerebral microbleeds in deep or infratentorial brain regions, not only in a cross-sectional analysis but also in a longitudinal analysis in subjects without microbleeds at baseline."

Microbleeds in deep (deep gray matter of the basal ganglia and thalamus and white matter of the corpus callosum, internal, external, and extreme capsule) or infratentorial (brainstem and cerebellum) locations are suggestive of hypertensive or arteriosclerotic disease in the small blood vessels. The prevalence of large vessel disease is known to be increased in COPD, and these new results "indicate that COPD might affect both large and small vessels," said Dr. Lahousse.

The findings were published online ahead of print publication in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

The study included 165 subjects with COPD and 645 subjects with normal lung function from the Rotterdam study, a prospective population-based cohort study in subjects ≥55 years. COPD diagnoses were confirmed by spirometry and cerebral microbleeds were detected with high-resolution MRI.

Compared with subjects with normal lung function, COPD patients had a significantly higher prevalence of cerebral microbleeds, which was independent of age, sex, smoking status, atherosclerotic large vessel disease, antithrombotic use, total cholesterol, triglycerides, and serum creatinin levels. The prevalence of microbleeds in deep or infratentorial locations was also significantly increased in COPD patients and the prevalence of these microbleeds increased with increasing severity of airflow limitation.

In a longitudinal analysis restricted to subjects without microbleed at baseline, COPD independently predicted incident cerebral microbleeds in deep or infratentorial locations.

The study had some limitations, including the cross-sectional design of the main analysis and the association of COPD with multiple comorbidities, some of which may affect cerebral small vessel disease.

"We have shown that COPD is associated with an increased risk of developing cerebral microbleeds in deep or infratentorial locations," said Dr. Lahousse. "Given the potential cognitive and functional consequences of these microbleeds, preventive strategies for vulnerable patients need to be developed."


'/>"/>

Contact: Nathaniel Dunford
ndunford@thoracic.org
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Risk of Coronary Disease Increases Every Year Someone is Obese
2. As Demand for PPACA Information Increases, United Benefit Advisors Names Chief Compliance Officer, Linda Rowings, “Staff Member of the Year”
3. TPA Continues to Keep Annual Employee Benefit Cost Increases to a Minimum without Sacrificing the Level of Quality
4. Growth in cerebral aneurysms increases risk of rupture
5. Pre-pregnancy diabetes increases risk of MRSA among new mothers
6. Exposure to BPA in developing prostate increases risk of later cancer
7. Childbirth increases risk of ACPA-negative rheumatoid arthritis
8. The Kravis Children’s Hospital at Mount Sinai Increases Number of Specialties Ranked in U.S. News & World Report “Best Children’s Hospitals”
9. Botox Popularity Increases With 20-Somethings
10. Dimension One Spa Filter Distributor, Easy Spa Parts, Increases Inventory of Factory Authorized Filters to Meet Demand and Eliminate Quality Issues
11. Child maltreatment increases risk of adult obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... NASHVILLE, Tenn. (PRWEB) , ... February 10, 2016 ... ... by the American Academy of Emergency Medicine , an emergency medicine ... of practice management services . , The American Academy of Emergency Medicine, ...
(Date:2/10/2016)... ... 2016 , ... 10 Best Water is excited to announce a ... owners that topped the list as a result of their commitment to offering clients ... was Tibet 5100, a top notch water company that specializes in providing the public ...
(Date:2/10/2016)... ... February 10, 2016 , ... Intalere’s 2016 Executive Forum, ... 200 of the country’s top healthcare executives to share insights on transformational strategies ... the Forum is the provider-centric perspective, experience, expertise and strategy shared by the ...
(Date:2/10/2016)... KALAMAZOO, MI (PRWEB) , ... February 10, 2016 , ... ... offer Apifiny® across their network of laboratory service centers across the country. ... designed to aid clinicians in the detection of prostate cancer. Apifiny order volume exceeded ...
(Date:2/10/2016)... , ... February 10, 2016 , ... ... will attend the Ohio Safety Congress and Expo event March 9-11, 2016. Hosted ... Greater Columbus Convention Center. , As the longest running and largest worker's ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... -- Antibacterial Drugs Market - Global Industry Analysis, ... reveals that the global antibacterial drugs market is forecast to ... to patent expiries of blockbuster drugs. Even though the market ... period, the value is anticipated to decline from US$43.9 bn ... Antibacterial Drugs Market - Global Industry Analysis, Size, Share, Growth, ...
(Date:2/10/2016)... KANSAS CITY, Mo. , Feb. 10, 2016 ... the pharmaceutical industry, recently identified an industry-wide trend ... a tool that allows organizations to efficiently deliver ... surveys, one in 2011 and another in 2015, ... are armed with tablet devices and DSAs, many ...
(Date:2/10/2016)... Feb. 9, 2016 On Tuesday, ... (FDA) met with its Arthritis Advisory Committee ... of Johnson & Johnson,s Remicade and most ... in the U.S. The Biologics Prescribers Collaborative ... - Alliance for Patient Access, American Association ...
Breaking Medicine Technology: