Navigation Links
CNIO scientists successfully test the first gene therapy against aging-associated decline
Date:5/14/2012

A number of studies have shown that it is possible to lengthen the average life of individuals of many species, including mammals, by acting on specific genes. To date, however, this has meant altering the animals' genes permanently from the embryonic stage an approach impracticable in humans. Researchers at the Spanish National Cancer Research Centre (CNIO), led by its director Mara Blasco, have proved that mouse lifespan can be extended by the application in adult life of a single treatment acting directly on the animal's genes. And they have done so using gene therapy, a strategy never before employed to combat ageing. The therapy has been found to be safe and effective in mice.

The results are published today in the journal EMBO Molecular Medicine. The CNIO team, in collaboration with Eduard Ayuso and Ftima Bosch of the Centre of Animal Biotechnology and Gene Therapy at the Universitat Autnoma de Barcelona (UAB), treated adult (one-year-old) and aged (two-year-old) mice, with the gene therapy delivering a "rejuvenating" effect in both cases, according to the authors.

Mice treated at the age of one lived longer by 24% on average, and those treated at the age of two, by 13%. The therapy, furthermore, produced an appreciable improvement in the animals' health, delaying the onset of age-related diseases like osteoporosis and insulin resistance and achieving improved readings on ageing indicators like neuromuscular coordination.

The gene therapy utilised consisted of treating the animals with a DNA-modified virus, the viral genes having been replaced by those of the telomerase enzyme, with a key role in ageing. Telomerase repairs the extremes of chromosomes, known as telomeres, and in doing so slows the cell's and therefore the body's biological clock. When the animal is infected, the virus acts as a vehicle depositing the telomerase gene in the cells.

This study "shows that it is possible to develop a telomer
'/>"/>

Contact: Juan J. Gomez
juanj.gomez@cnio.es
34-917-328-000-4060
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
CNIO scientists successfully test the first gene therapy against aging-associated decline
(Date:8/21/2014)... CA (PRWEB) August 21, 2014 Sleep Apnea ... across the U.S. This provides doctors with a convenient way ... find a doctor are that much closer to finding ... have no idea they are experiencing this sleep disorder ... receive treatment at all. , Thanks to Sleep Apnea Doctors ...
(Date:8/21/2014)... Cary, NC (PRWEB) August 21, 2014 ... solutions for the health and human services markets, announced ... features and capabilities incorporating the Tin Can API. ... and their employees have the most advanced mobile learning ... greatest in adult learning tools and techniques,” says Jim ...
(Date:8/21/2014)... ERT, a leading global solution ... endpoint data collection, today opened registration for ... Product Value with Optimized Endpoints. The ... developers to network with leading researchers as ... implementing, and justifying effective strategies for collecting ...
(Date:8/21/2014)... elicited by T-type calcium channels in the thalamic ... of calcium. These channels enable thalamic reticular nucleus ... to enter a hyper-excited state. , In order ... absence seizures, the researchers conducted an experiment to ... techniques to delete the T-type calcium channel CaV3.3. ...
(Date:8/21/2014)... Do we drive to work or take the train? From ... make hundreds of different decisions every day. Even if these ... for our long-term personal development to make decisions that are ... difficult, however. They are known to make impulsive decisions, often ... of making a choice that yields a greater reward later ...
Breaking Medicine News(10 mins):Health News:Sleep Apnea Doctors US is Now Offering Complimentary Listings to Sleep Apnea Doctors Across the United States 2Health News:Relias Learning Announces Support for Tin Can API 2Health News:ERT Opens Registration for PROFICIENCY™ Regional Conference Series 2Health News:ERT Opens Registration for PROFICIENCY™ Regional Conference Series 3Health News:ADHD children make poor decisions due to less differentiated learning processes 2
... SOUTH SAN FRANCISCO, Calif., July 29 Poniard Pharmaceuticals, Inc. ... innovative oncology therapies, today announced that Jerry McMahon, Ph.D., chairman ... overview, including a discussion about the clinical development program for ... conferences: , , , ...
... , SAN DIEGO, July 29, 2009 Arena ... will report second quarter 2009 financial results after the NASDAQ ... afternoon, Jack Lief, Arena,s President and Chief Executive Officer, and ... Officer, will host a conference call at 5:00 p.m. Eastern ...
... , JACKSONVILLE, Fla., July 29 Today, Wounded ... bill (H.R. 3155) that will assist the family caregivers of ... (S. 801) that would provide more comprehensive support and coverage ... need of these services. H.R. 3155, the Caregiver Assistance and ...
... SAN FRANCISCO, July 29 Medivation, Inc. (Nasdaq: ... and webcast with management to discuss second quarter 2009 financial results ... at 4:30 p.m. Eastern Time. A press release for the second ... on August 5, 2009. , , Interested parties ...
... , , , , ... Carefx Corporation , a leading provider of interoperable workflow ... that one of its clients, the Louisiana Rural Health Information Exchange (LARHIX), ... Health Information Executives , a top healthcare information technology magazine. ...
... , , MONROVIA, ... ), a leading developer, manufacturer and marketer of minimally invasive ophthalmic ... Officer will present at the BMO Capital Markets 9th Annual Focus ... 5th at 4:00 pm Eastern Time. , , ...
Cached Medicine News:Health News:Poniard Pharmaceuticals to Present at Two Upcoming Investor Conferences in August 2Health News:Arena Pharmaceuticals to Host Business and Financial Update Conference Call and Webcast on Monday, August 3, 2009 2Health News:Arena Pharmaceuticals to Host Business and Financial Update Conference Call and Webcast on Monday, August 3, 2009 3Health News:Wounded Warrior Project (WWP) Pushes for Senate Bill to Assist Family Caregivers of the Most Severely Injured Veterans 2Health News:Medivation Announces Second Quarter 2009 Financial Results Teleconference and Webcast on August 5, 2009 2Health News:Top Healthcare Magazine Awards Carefx Client '2009 IT Project of the Year' 2Health News:Top Healthcare Magazine Awards Carefx Client '2009 IT Project of the Year' 3
(Date:8/21/2014)... Aug. 21, 2014  Decision Resources Group finds ... Brazil and ... and commonly prescribe long-acting beta-agonist (LABA)- and long-acting ... so within current severe cost/coverage constraints. Therefore, new ... expected to launch in these countries—which will considerably ...
(Date:8/21/2014)... , Aug. 21, 2014  Seventy-one percent of Americans ... OxyContin is a serious public health and safety issue in ... from a survey released today by Repass & Partners, a ... "Americans understand the severity of the prescription medication ... progress with this very serious health situation facing our country," ...
(Date:8/21/2014)... Aug. 21, 2014  Henry Schein, Inc. (NASDAQ: ... and services to office-based dental, animal health and medical practitioners, ... conferences in September: , September 4, 2014 – ... , NY at 12:50 p.m. ET , September 8, 2014 ... New York , NY at 1:25 p.m. ET ...
Breaking Medicine Technology:Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 2Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 3Consumers Desperate For Measures To Curb Prescription Drug Abuse 2Consumers Desperate For Measures To Curb Prescription Drug Abuse 3Henry Schein To Present At Two Investor Conferences In September 2
... 4, 2011 /PRNewswire-Asia-FirstCall/ -- Dehaier Medical Systems Ltd. ... "Company"), an emerging leader in the development, assembly, marketing ... in China, today announced that it will release financial ... June 30, 2011 on Monday, August 15, 2011 before ...
... Medical, Inc. (OTCBB: HASC), www.mysouthernmed.com , a ... Florida, and Mississippi, announced today that the Chairman ... guaranteed the financing that was used for the ... on May 17th, 2011. As part ...
Cached Medicine Technology:Dehaier Medical to Report Second Quarter 2011 Financial Results on August 15 2HASCO Medical Chairman Provides $2 Million in Capital and a Personal Guarantee on Additional $2 Million Promissory Note 2HASCO Medical Chairman Provides $2 Million in Capital and a Personal Guarantee on Additional $2 Million Promissory Note 3
... to U.S. and international engineering and ... Screw and Plating System* provides seamless ... of use for open reduction internal ... TC-100 system works well beyond the ...
... The Alphatec Small Fragment ... wide range of fractures, including ... distal humerus, distal radius, distal ... malleolus, metatarsals, and metacarpals. The ...
Stainless steel threaded Steinman Pins available in point types A,D, E, and F....
Round Bevel-Point Pin Sets available in 2.3mm, 3.1mm, 4.7mm, and 6.3mm sizes....
Medicine Products: