Navigation Links
CNIO scientists reduce progression of one of the most aggressive skin cancers in mice
Date:9/27/2013

The c-Fos oncogene has traditionally been linked to cellular activities related to cancer, such as cell division, differentiationconversion from one cell type to anotheror survival. Any alteration of these activities can set off the development of tumours, which has made c-Fos an important target for the understanding and treatment of cancer.

A study led by Erwin Wagner, head of the F-BBVA-CNIO Cancer Cell Biology Programme and of the Genes, Development and Disease Group, has revealed a novel mechanism in which c-Fos is able to promote skin cancer: an increase in c-Fos expression in the skin stimulates the immune system, which induces the appearance of squamous cell carcinomas (SCCs), one of the most aggressive skin cancers.

Another important result from this study is the observation in mice of a decrease in the progression of SCCs by using anti-inflammatory drugs, which block the immune response induced by c-Fos. The conclusions are published in the latest issue of the journal Genes and Development, and are featured on its cover.

THE IMMUNE SYSTEM: TWO SIDES OF THE SAME COIN

The classic way of looking at inflammatory immune response, which is more than 100 years old, asserts that defence mechanisms protect the organism when faced with neoplasms. This vision has given way over the last few years to new evidence that suggests chronic inflammation favours the proliferation and survival of tumour cells, thus increasing susceptibility to cancer.

"We know that there are cancers, like pancreatic, liver or colon cancer, in which the inflammatory component plays a very important role in the development of the disease", says Juan Guinea-Viniegra, a researcher from Wagner's team.

Furthermore, inflammatory skin diseases, such as lupus or chronic ulcers, predispose patients to develop tumours, although for now the mechanisms responsible for this phenomenon had not been discovered.

The research sheds light on this question for the first time. Eva Briso, first author of the study says: "We have discovered that mice that have higher c-Fos expression in the skin promote the recruitment of immune cells, known as CD4+T, leading to the development of skin lesions and carcinogenesis".

Briso adds that when mice were treated with anti-inflammatory drugs that specifically blocked CD4+T cell-mediated immune response, tumours decreased.

Furthermore, the researchers analysed samples from nearly a hundred patients with SCCs, in which they found that up to 75% of the tumours displayed increased c-Fos expression, as well as an increase in inflammatory activity.

These results open up the possibility of using anti-inflammatory drugs as a means of treating patients with this pathology. "If we find molecules that in patients are able to block this immune response, we could think about a new specific therapy for this disease", says Wagner.

Squamous cell carcinoma is a very aggressive type of skin cancer that can invade other tissues and form metastasis. It affects 16 out of every 100,000 people in Europe and is the type of skin cancer most related to sun exposure. Due to the few biological and molecular data available on the disease, the standard treatment is reduced to surgery and radiotherapy.


'/>"/>

Contact: Nuria Noriega
comunicacion@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert

Related medicine news :

1. Chicago Public High School Students to Rub Shoulders with Scientists from Around the World
2. NIH scientists pursue new therapies to improve rare disease drug development
3. NCI scientists identify targets for melanoma immunotherapy
4. Peering into Genetic Defects, CU Scientists Discover a New Metabolic Disease
5. What scientists can see in your pee
6. St. Jude Childrens Research Hospital scientists identify ALS disease mechanism
7. NIH-funded scientists describe genesis, evolution of H7N9 influenza virus
8. American Scientists Attempt to Sequence John Lennon's Genetic Code from the Beatle's Tooth
9. Harvard Scientists Commend Erchonia for Excellence in Clinical Research for the Zerona Laser
10. Is There a Science to Hiring? Demand for Scientists Grows 6%
11. UCLA and Chinese scientists analyze genetic makeup of human and mouse embryos in amazing detail
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... ... December 08, 2016 , ... ... serve communities in and around the greater Phoenix metropolitan region, is announcing a ... , The mission of the Homeless Youth Connection is to promote community awareness ...
(Date:12/8/2016)... ... December 08, 2016 , ... Bill ... and business owners in and around central Kansas, is joining the Youth Horizons ... in the region. , Headquartered in Wichita, Youth Horizons works to empower area ...
(Date:12/7/2016)... Wisconsin (PRWEB) , ... December 07, 2016 , ... Kenall ... extraordinary new MedMaster™ MPCNGX . The MPCNGX is a multi-function, sealed, LED luminaire ... right amount of light where and when it’s needed. , A 2’ ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... up with a schizophrenic mother in a unique, personal perspective through animation. ... treating trauma and addictive disorders at her private psychotherapy practice. Sheri’s mother, Pearl, ...
(Date:12/7/2016)... ... December 07, 2016 , ... Castle Dermatology Institute is now offering liquid ... a more youthful appearance to the face. Dr. Peyman Ghasri and Dr. Pedram Ghasri, ... of other treatments, to rejuvenate and renew the facial appearance. , Sculptra is ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... 7, 2016  Urinary catheters are used for ... other urological disorders. Urinary catheters include indwelling (Foley) ... Indwelling or Foley catheter is a flexible tube ... catheter is inserted into the bladder through the ... balloon attachment at one end of the catheter ...
(Date:12/7/2016)... YORK , Dec. 7, 2016 Global ... This report on the global hospital linen supply and ... of this market on a global and regional level. ... forecast for the period between 2015 and 2024 based ... the dynamics of the market along with their impact ...
(Date:12/7/2016)... , Dec. 7, 2016 A new investigational drug ... human clinical trials in search of the world,s first treatment ... publication of research findings today in the journal ... will be a watershed moment for millions of people living ... director of Van Andel Research Institute,s Center ...
Breaking Medicine Technology: