Navigation Links
CNIO scientists reduce progression of one of the most aggressive skin cancers in mice
Date:9/27/2013

The c-Fos oncogene has traditionally been linked to cellular activities related to cancer, such as cell division, differentiationconversion from one cell type to anotheror survival. Any alteration of these activities can set off the development of tumours, which has made c-Fos an important target for the understanding and treatment of cancer.

A study led by Erwin Wagner, head of the F-BBVA-CNIO Cancer Cell Biology Programme and of the Genes, Development and Disease Group, has revealed a novel mechanism in which c-Fos is able to promote skin cancer: an increase in c-Fos expression in the skin stimulates the immune system, which induces the appearance of squamous cell carcinomas (SCCs), one of the most aggressive skin cancers.

Another important result from this study is the observation in mice of a decrease in the progression of SCCs by using anti-inflammatory drugs, which block the immune response induced by c-Fos. The conclusions are published in the latest issue of the journal Genes and Development, and are featured on its cover.

THE IMMUNE SYSTEM: TWO SIDES OF THE SAME COIN

The classic way of looking at inflammatory immune response, which is more than 100 years old, asserts that defence mechanisms protect the organism when faced with neoplasms. This vision has given way over the last few years to new evidence that suggests chronic inflammation favours the proliferation and survival of tumour cells, thus increasing susceptibility to cancer.

"We know that there are cancers, like pancreatic, liver or colon cancer, in which the inflammatory component plays a very important role in the development of the disease", says Juan Guinea-Viniegra, a researcher from Wagner's team.

Furthermore, inflammatory skin diseases, such as lupus or chronic ulcers, predispose patients to develop tumours, although for now the mechanisms responsible for this phenomenon had not been discovered.

The research she
'/>"/>

Contact: Nuria Noriega
comunicacion@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Chicago Public High School Students to Rub Shoulders with Scientists from Around the World
2. NIH scientists pursue new therapies to improve rare disease drug development
3. NCI scientists identify targets for melanoma immunotherapy
4. Peering into Genetic Defects, CU Scientists Discover a New Metabolic Disease
5. What scientists can see in your pee
6. St. Jude Childrens Research Hospital scientists identify ALS disease mechanism
7. NIH-funded scientists describe genesis, evolution of H7N9 influenza virus
8. American Scientists Attempt to Sequence John Lennon's Genetic Code from the Beatle's Tooth
9. Harvard Scientists Commend Erchonia for Excellence in Clinical Research for the Zerona Laser
10. Is There a Science to Hiring? Demand for Scientists Grows 6%
11. UCLA and Chinese scientists analyze genetic makeup of human and mouse embryos in amazing detail
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... NJ (PRWEB) September 19, 2014 Visiting ... provider of home health care, hospice and palliative care ... to ring the Opening Bell yesterday at the New ... New Jersey philanthropist and social entrepreneur to care for ... Health Group has always worked to meet the urgent ...
(Date:9/19/2014)... (HealthDay News) -- U.S. military troops deployed to sunny ... according to a new study. Many returning ... In some cases, military personnel developed blisters on their ... or size of their moles since being deployed overseas. ... for skin cancer, the study authors noted. "The ...
(Date:9/19/2014)... 2014 (HealthDay News) -- Although there is mounting ... most middle-aged and older adults in the United ... according to new research. Less than one-quarter ... set by the Department of Health and Human ... essential for promoting health and fitness and staying ...
(Date:9/19/2014)... (PRWEB) September 19, 2014 The ... important partnership with the National Fire Protection Association ... The collaboration, formalized today in a Memorandum of ... Members, factories, workers and other stakeholders with information, ... help protect the health and safety of workers ...
(Date:9/19/2014)... intact cells to treat and cure disease is ... is hindered by the inability of doctors and scientists ... these cells in patients without resorting to invasive procedures, ... 17 in the online journal Magnetic Resonance in ... Diego School of Medicine, University of Pittsburgh and elsewhere ...
Breaking Medicine News(10 mins):Health News:NJ Largest Home Healthcare Not-for-Profit Joins Deutsche Bank to Ring NYSE Opening Bell 2Health News:NJ Largest Home Healthcare Not-for-Profit Joins Deutsche Bank to Ring NYSE Opening Bell 3Health News:Some U.S. Troops May Face Greater Skin Cancer Risk 2Health News:Adults Over 45 Not Meeting U.S. Muscle Strengthening Guidelines, Study Says 2Health News:Alliance for Bangladesh Worker Safety and NFPA Sign Memorandum of Understanding to Strengthen Safety in Bangladesh Garment Factories 2Health News:Alliance for Bangladesh Worker Safety and NFPA Sign Memorandum of Understanding to Strengthen Safety in Bangladesh Garment Factories 3Health News:A better way to track emerging cell therapies using MRIs 2
... Ann Converso, RN, to Serve as President, WASHINGTON, ... the death of President Cheryl L. Johnson,RN. Johnson was ... Oct. 19, with a ruptured brain aneurysm and died ... friends., "Cheryl was a guiding force in the ...
... BASEL, Switzerland, Oct. 29 Roche (SWX: ROG.VX; RO.S),a ... it has extended its offer to acquire all of ... VMSI ),to 5:00 p.m., New York City time ... scheduled to expire at 5:00 p.m., New York City ...
... experts will summarize important new research on the ... consequences of acute kidney injury, racial and ethnic ... kidney disease patients, being presented during the American ... Exposition in San Francisco at a policy-centered news ...
... Fund Launch National Campaign to Inspire and ... Educate that Prevention is Possible, BERKELEY, Calif., Oct. ... in their lifetime. Although 50 percent,of women think breast cancer is ... of the disease. LUNA, the makers of whole nutrition bars ...
... ... Provider Earns $1.6 Million in Rebates This Year, Highlights ... Redwood City Project, REDWOOD ... nation,s largest not-for-profit,health plan, will today celebrate significant energy efficiency upgrades,and solar installations ...
... Cardiac Science,Corporation (Nasdaq: CSCX ), a ... announced today that it will present at the,18th ... York City. The,Company,s presentation is scheduled for Monday, ... Hinson, president and chief executive officer, will,review the ...
Cached Medicine News:Health News:UAN Mourns Passing of President Cheryl L. Johnson, RN 2Health News:Roche Extends Tender Offer for Ventana 2Health News:Roche Extends Tender Offer for Ventana 3Health News:Roche Extends Tender Offer for Ventana 4Health News:LUNA Pure Prevention Survey Confirms Breast Cancer Misconceptions 2Health News:LUNA Pure Prevention Survey Confirms Breast Cancer Misconceptions 3Health News:The Healing Power of Green 2Health News:The Healing Power of Green 3Health News:Cardiac Science to Present at the 18th Annual CIBC World Markets Healthcare Conference 2
(Date:9/19/2014)... 2014  Pressure BioSciences, Inc. (OTCQB: PBIO) ("PBI" ... and approved all parts required to build nine ... to manufacture the new PCT-based instrument system.  The ... for shipment by mid-October and that additional Barozyme ... rate of about one per week thereafter.  ...
(Date:9/19/2014)... and ORLANDO, Fla. , Sept. ... Inspire therapy continues to grow, with the publication of ... on-line in Otolaryngology – Head and Neck ... a worsening of both objective and subjective measures of ... attribute Inspire therapy for the reduction in obstructive sleep ...
(Date:9/19/2014)... , Sept. 19, 2014 Intarcia Therapeutics, ... clinical data for its lead candidate ITCA 650 (continuous ... with high baseline HbA1c levels at the 50 th ... Study of Diabetes (EASD). Data from the open-label, phase ... of blood sugar in patients with poorly controlled type ...
Breaking Medicine Technology:Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 2Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 3New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 2New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 3New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 4Intarcia Announces Presentation of Phase 3 Data at EASD Showing ITCA 650 Markedly Reduces Blood Sugar In Patients With Poorly Controlled Type 2 Diabetes 2Intarcia Announces Presentation of Phase 3 Data at EASD Showing ITCA 650 Markedly Reduces Blood Sugar In Patients With Poorly Controlled Type 2 Diabetes 3Intarcia Announces Presentation of Phase 3 Data at EASD Showing ITCA 650 Markedly Reduces Blood Sugar In Patients With Poorly Controlled Type 2 Diabetes 4
... Diagnostics, one of the leading providers of arrhythmia ... technology with cardiac care to provide leading edge ... eCardio with machine-to-machine (M2M) wireless data ... of cardiac patients. eCardio,s monitoring solution on cardiac ...
... and SEATTLE, Oct. 7 VentiRx Pharmaceuticals, Inc., ... novel Toll-Like Receptor 8 (TLR8) candidates for the ... today results from its randomized, placebo controlled clinical ... rhinitis. The results demonstrated that VTX-1463 significantly improved ...
Cached Medicine Technology:AT&T and eCardio Diagnostics Team Up to Advance Cardiac Care Through Innovative Mobile Technology 2AT&T and eCardio Diagnostics Team Up to Advance Cardiac Care Through Innovative Mobile Technology 3VentiRx Pharmaceuticals Reports Positive Clinical Data for VTX-1463 in Allergic Rhinitis 2
Jaws with fine teeth. Serrated handle with polished finish. Jaws: Wide, 4.5 mm. With thumb catch lock....
Straight shafts with heavy Elschnig teeth. Flat serrated handle with slide style lock and polished finished....
Serrated handle with polished finish. Non-magnetic. Straight tips: Delicate 11 mm. Most popular size or model....
Delicate strong curved serrated tips. Serrated handle with dull finish....
Medicine Products: