Navigation Links
CNIO scientists reduce progression of one of the most aggressive skin cancers in mice
Date:9/27/2013

The c-Fos oncogene has traditionally been linked to cellular activities related to cancer, such as cell division, differentiationconversion from one cell type to anotheror survival. Any alteration of these activities can set off the development of tumours, which has made c-Fos an important target for the understanding and treatment of cancer.

A study led by Erwin Wagner, head of the F-BBVA-CNIO Cancer Cell Biology Programme and of the Genes, Development and Disease Group, has revealed a novel mechanism in which c-Fos is able to promote skin cancer: an increase in c-Fos expression in the skin stimulates the immune system, which induces the appearance of squamous cell carcinomas (SCCs), one of the most aggressive skin cancers.

Another important result from this study is the observation in mice of a decrease in the progression of SCCs by using anti-inflammatory drugs, which block the immune response induced by c-Fos. The conclusions are published in the latest issue of the journal Genes and Development, and are featured on its cover.

THE IMMUNE SYSTEM: TWO SIDES OF THE SAME COIN

The classic way of looking at inflammatory immune response, which is more than 100 years old, asserts that defence mechanisms protect the organism when faced with neoplasms. This vision has given way over the last few years to new evidence that suggests chronic inflammation favours the proliferation and survival of tumour cells, thus increasing susceptibility to cancer.

"We know that there are cancers, like pancreatic, liver or colon cancer, in which the inflammatory component plays a very important role in the development of the disease", says Juan Guinea-Viniegra, a researcher from Wagner's team.

Furthermore, inflammatory skin diseases, such as lupus or chronic ulcers, predispose patients to develop tumours, although for now the mechanisms responsible for this phenomenon had not been discovered.

The research she
'/>"/>

Contact: Nuria Noriega
comunicacion@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Chicago Public High School Students to Rub Shoulders with Scientists from Around the World
2. NIH scientists pursue new therapies to improve rare disease drug development
3. NCI scientists identify targets for melanoma immunotherapy
4. Peering into Genetic Defects, CU Scientists Discover a New Metabolic Disease
5. What scientists can see in your pee
6. St. Jude Childrens Research Hospital scientists identify ALS disease mechanism
7. NIH-funded scientists describe genesis, evolution of H7N9 influenza virus
8. American Scientists Attempt to Sequence John Lennon's Genetic Code from the Beatle's Tooth
9. Harvard Scientists Commend Erchonia for Excellence in Clinical Research for the Zerona Laser
10. Is There a Science to Hiring? Demand for Scientists Grows 6%
11. UCLA and Chinese scientists analyze genetic makeup of human and mouse embryos in amazing detail
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/4/2015)... ... August 04, 2015 , ... ... brings an automatic end to driving, says the August 2015 Harvard Health Letter. ... okay to drive. It requires an individual assessment of skills," says Lissa Kapust, ...
(Date:8/4/2015)... NY (PRWEB) , ... August 04, 2015 , ... ... mortgage lender specializing in healthcare finance, announced the closing of a $118 million ... two campus health system located in Smithfield and Clayton, North Carolina. JHSC ...
(Date:8/4/2015)... (PRWEB) , ... August 04, 2015 , ... ... Process Chemistry and Scale-up Online Seminar featuring researchers from Lubrizol, Pfizer, and ... at 1:00 PM EDT. , Process development project timelines often require informed decisions ...
(Date:8/4/2015)... (PRWEB) , ... August 04, 2015 , ... Updated enrollment ... (AIS) in-house research team, can now be accessed at http://www.AISHealth.com . The data ... Directory of Health Plans: 2015, the tables and charts on the website’s “Data” section ...
(Date:8/4/2015)... Ill. (PRWEB) , ... August 04, 2015 , ... ... and the specialty in which the physician is board-certified is increasingly influential in ... for Dermatologic Surgery. , The 2015 ASDS Consumer Survey on Cosmetic Dermatologic Procedures ...
Breaking Medicine News(10 mins):Health News:Assessment Can Help Older Drivers Keep Driving Safely, from the August 2015 Harvard Health Letter 2Health News:Armadale Capital Inc. Refinances $118 Million for Johnston Health Services Corporation 2Health News:Armadale Capital Inc. Refinances $118 Million for Johnston Health Services Corporation 3Health News:METTLER TOLEDO Announces New Process Chemistry and Scale-up Online Seminar 2Health News:Atlantic Information Services Website Offers Up-to-Date U.S. Health Plan Enrollment Data 2Health News:ASDS Survey: Half of Consumers Considering Cosmetic Procedure 2Health News:ASDS Survey: Half of Consumers Considering Cosmetic Procedure 3Health News:ASDS Survey: Half of Consumers Considering Cosmetic Procedure 4
... driving the trend, study says , , TUESDAY, Nov. 6 ... disease is on the rise, and diabetes and high blood ... the increase, a new study suggests. , "When we looked ... was more common than previously appreciated," said lead researcher Dr. ...
... ... http://www.amerathonclub.com Encourages Consistent Exercise for Individuals and ... Families -, PITTSBURGH, ... while maintaining a healthy,lifestyle. The Amerathon Club has introduced a new online and interactive,total ...
... Healthcare NHS Trust Implements Ericom,s Alternative to Citrix ... ... 6 ,Ericom(R) Software, a leading provider of Enterprise-Wide Application,Access solutions, ... selected PowerTerm(R) WebConnect Enterprise edition to provide,employees with secure access ...
... is available in Spanish . , ANN ARBOR, Mich. ... the fact that nearly one in five American women still smokes, ... possible reasons for the stubborn persistence of smoking, fear of weight ... University of Michigan Health System researcher who has devoted much of ...
... work together to maintain addiction, study suggests , , TUESDAY, ... know all too well, drinking and smoking tend to ... might be so. , It,s well known that, "The ... someone continues smoking," noted lead researcher Thomas J. Gould, ...
... for State,s Second Site, ATLANTA, Nov. 6 ... has named Atlanta Medical Center as Georgia,s second,hospital ... March,of Dimes NICU Family Support(R) provides information and ... newborns being cared for in,a Neonatal Intensive Care ...
Cached Medicine News:Health News:Kidney Disease Increasing in U.S. 2Health News:Kidney Disease Increasing in U.S. 3Health News:Innovative Amerathon Club Website 'Virtual' Journey to Good Health 2Health News:UK Government (NHS) Selects Ericom to Enable Secure Application Access for its Medical and Administrative Staff 2Health News:Is fear of gaining weight keeping many women from trying to quit smoking? 2Health News:Is fear of gaining weight keeping many women from trying to quit smoking? 3Health News:Is fear of gaining weight keeping many women from trying to quit smoking? 4Health News:Nicotine Plus Alcohol May Be Tough to Beat 2Health News:Nicotine Plus Alcohol May Be Tough to Beat 3Health News:Georgia Receives Second March of Dimes NICU Family Support(R) Project 2Health News:Georgia Receives Second March of Dimes NICU Family Support(R) Project 3
(Date:8/4/2015)... 2015  Syneron Medical Ltd. (NASDAQ: ELOS ), a ... the three month period ended June 30, 2015. ... Highlights: , Revenue of $73.5 million, ... North American product sales grew 45% year-over-year. , International ... 14% product growth in the EMEA region and 25% product ...
(Date:8/4/2015)... , Aug. 4, 2015  Ironshore Pharmaceuticals ... with Restore Health, a company specializing in personalized ... double-blind clinical trial, designed to evaluate the safety ... development to treat Attention-deficit/hyperactivity disorder (ADHD). This is ... Restore Health originally partnered with Ironshore in ...
(Date:8/3/2015)... Aug. 4, 2015   The Intellectual Property ... world,s leading provider of intelligent information for businesses ... 2015 CMR Pharmaceutical R&D Factbook , the biopharmaceutical ... concerns around declines in R&D, the analysis identifies ... trillion milestone and forecasts sales to reach $1.3 ...
Breaking Medicine Technology:Syneron Medical Reports Revenue of $73.5 Million for the Second Quarter 2015 2Syneron Medical Reports Revenue of $73.5 Million for the Second Quarter 2015 3Syneron Medical Reports Revenue of $73.5 Million for the Second Quarter 2015 4Syneron Medical Reports Revenue of $73.5 Million for the Second Quarter 2015 5Syneron Medical Reports Revenue of $73.5 Million for the Second Quarter 2015 6Syneron Medical Reports Revenue of $73.5 Million for the Second Quarter 2015 7Syneron Medical Reports Revenue of $73.5 Million for the Second Quarter 2015 8Syneron Medical Reports Revenue of $73.5 Million for the Second Quarter 2015 9Syneron Medical Reports Revenue of $73.5 Million for the Second Quarter 2015 10Syneron Medical Reports Revenue of $73.5 Million for the Second Quarter 2015 11Syneron Medical Reports Revenue of $73.5 Million for the Second Quarter 2015 12Syneron Medical Reports Revenue of $73.5 Million for the Second Quarter 2015 13Syneron Medical Reports Revenue of $73.5 Million for the Second Quarter 2015 14Syneron Medical Reports Revenue of $73.5 Million for the Second Quarter 2015 15Syneron Medical Reports Revenue of $73.5 Million for the Second Quarter 2015 16Syneron Medical Reports Revenue of $73.5 Million for the Second Quarter 2015 17Restore Health Secures Another Clinical Trial with Ironshore Pharmaceuticals & Development 2Pharma Sales to Grow Beyond $1 Trillion 2
... NEW YORK, Feb. 2, 2011 Reportlinker.com announces that ... catalogue: US Prebiotics Industry ... report analyzes the US And European markets for Prebiotics ... is further analyzed by the following product segments: Mannan-Oligosaccharide ...
... Feb. 2, 2011 H. D. Smith recently announced ... strategic planning and business development, Robert Appleby to corporate ... vice president marketing.  These appointments are the latest organizational ... address evolving customer needs. Joseph ...
Cached Medicine Technology:US Prebiotics Industry 2US Prebiotics Industry 3US Prebiotics Industry 4US Prebiotics Industry 5US Prebiotics Industry 6US Prebiotics Industry 7H. D. Smith Aligns Leadership Positions to Fill Three Senior Roles 2
Designed to give maximum drying area while taking up minimal bench space....
Used to remove wrinkles from sections and for reorientating embedded tissue....
Compact instrument that quickly dries racks of slides using warm air....
Liquichek Blood Gas Plus CO-Oximeter Control (IL Synthesis Series) is a combination control for use in monitoring the performance of blood gas, ion-selective electrode, biosensor and CO-Oximetry anal...
Medicine Products: