Navigation Links
CNIO scientists reduce progression of one of the most aggressive skin cancers in mice
Date:9/27/2013

The c-Fos oncogene has traditionally been linked to cellular activities related to cancer, such as cell division, differentiationconversion from one cell type to anotheror survival. Any alteration of these activities can set off the development of tumours, which has made c-Fos an important target for the understanding and treatment of cancer.

A study led by Erwin Wagner, head of the F-BBVA-CNIO Cancer Cell Biology Programme and of the Genes, Development and Disease Group, has revealed a novel mechanism in which c-Fos is able to promote skin cancer: an increase in c-Fos expression in the skin stimulates the immune system, which induces the appearance of squamous cell carcinomas (SCCs), one of the most aggressive skin cancers.

Another important result from this study is the observation in mice of a decrease in the progression of SCCs by using anti-inflammatory drugs, which block the immune response induced by c-Fos. The conclusions are published in the latest issue of the journal Genes and Development, and are featured on its cover.

THE IMMUNE SYSTEM: TWO SIDES OF THE SAME COIN

The classic way of looking at inflammatory immune response, which is more than 100 years old, asserts that defence mechanisms protect the organism when faced with neoplasms. This vision has given way over the last few years to new evidence that suggests chronic inflammation favours the proliferation and survival of tumour cells, thus increasing susceptibility to cancer.

"We know that there are cancers, like pancreatic, liver or colon cancer, in which the inflammatory component plays a very important role in the development of the disease", says Juan Guinea-Viniegra, a researcher from Wagner's team.

Furthermore, inflammatory skin diseases, such as lupus or chronic ulcers, predispose patients to develop tumours, although for now the mechanisms responsible for this phenomenon had not been discovered.

The research sheds light on this question for the first time. Eva Briso, first author of the study says: "We have discovered that mice that have higher c-Fos expression in the skin promote the recruitment of immune cells, known as CD4+T, leading to the development of skin lesions and carcinogenesis".

Briso adds that when mice were treated with anti-inflammatory drugs that specifically blocked CD4+T cell-mediated immune response, tumours decreased.

Furthermore, the researchers analysed samples from nearly a hundred patients with SCCs, in which they found that up to 75% of the tumours displayed increased c-Fos expression, as well as an increase in inflammatory activity.

These results open up the possibility of using anti-inflammatory drugs as a means of treating patients with this pathology. "If we find molecules that in patients are able to block this immune response, we could think about a new specific therapy for this disease", says Wagner.

Squamous cell carcinoma is a very aggressive type of skin cancer that can invade other tissues and form metastasis. It affects 16 out of every 100,000 people in Europe and is the type of skin cancer most related to sun exposure. Due to the few biological and molecular data available on the disease, the standard treatment is reduced to surgery and radiotherapy.


'/>"/>

Contact: Nuria Noriega
comunicacion@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert

Related medicine news :

1. Chicago Public High School Students to Rub Shoulders with Scientists from Around the World
2. NIH scientists pursue new therapies to improve rare disease drug development
3. NCI scientists identify targets for melanoma immunotherapy
4. Peering into Genetic Defects, CU Scientists Discover a New Metabolic Disease
5. What scientists can see in your pee
6. St. Jude Childrens Research Hospital scientists identify ALS disease mechanism
7. NIH-funded scientists describe genesis, evolution of H7N9 influenza virus
8. American Scientists Attempt to Sequence John Lennon's Genetic Code from the Beatle's Tooth
9. Harvard Scientists Commend Erchonia for Excellence in Clinical Research for the Zerona Laser
10. Is There a Science to Hiring? Demand for Scientists Grows 6%
11. UCLA and Chinese scientists analyze genetic makeup of human and mouse embryos in amazing detail
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2017)... New York, NY (PRWEB) , ... May 26, 2017 , ... ... "Skin Health & Wound Care" campaign in USA Today, which will educate readers on ... Health side of the campaign, a large focus is placed on melanoma. Dancing with ...
(Date:5/26/2017)... ... May 26, 2017 , ... ... CareFusion NOX-T3 portable sleep monitor with its Somnoware Sleep Device Interface (SDI). Somnoware ... for diagnostic device operations. With this platform, initializing devices and importing studies are ...
(Date:5/26/2017)... ... May 26, 2017 , ... After raising nearly $30,000 on Kickstarter ... to be available at a discounted crowdfunding price on Indiegogo . , “Along ... I also wanted to bring a fidget toy to the market that was made ...
(Date:5/26/2017)... ... May 26, 2017 , ... “When the Stars Lead Home”: a poignant ... of published author Laura Weigel Douglas, an avid reader who lives in the Pacific ... sometimes feels like Green Hills Adventure Camp. She couldn’t be more grateful. , Twelve-year ...
(Date:5/26/2017)... , ... May 26, 2017 , ... Water damage to ... New Jersey School District had left education officials with a number of critical issues ... of the flooring had to be accomplished with little or no disruption to class ...
Breaking Medicine News(10 mins):
(Date:5/15/2017)... PHILADELPHIA , May 15, 2017 Enterin Inc., ... and developing novel compounds to treat Parkinson,s disease ... The study is a Phase 1/2a randomized, controlled, multicenter study ... sites. It will enroll 50 patients over a 9-to-12-month period. ... doses in 10 patients with PD. Participating sites include ...
(Date:5/10/2017)... WASHINGTON , May 10, 2017  The ... doctors or employees of sleep therapy clinics to ... a sleep therapy clinic is involved in a ... as interested in hearing from an employee of ... involved in a kickback scheme to provide medical practice ...
(Date:5/9/2017)... , May 9, 2017  Oramed Pharmaceuticals ... ), a clinical-stage pharmaceutical company focused on the ... that the Canadian Intellectual Property Office has granted ... Oral Administration of Exenatide". The patent covers Oramed,s ... GLP-1 is an incretin hormone that ...
Breaking Medicine Technology: