Navigation Links
CNIO scientists create the first large catalog of interactions between drugs and proteins
Date:12/2/2013

The three-dimensional structures of proteins determine how, when and where they bind to drugs and other compounds. In 2012 alone, thousands of structures like this were resolved. Now this mass of information needs to be translated into a biological context that can be used to extract relevant functions from these interactions, as well as significant pharmacological and disease-related effects.

A Spanish National Cancer Research Centre (CNIO) work, led by Alfonso Valencia, Vice-Director of Basic Research, and Michael L. Tress, a researcher on his team, brings together the biggest collection of interactions between pharmacological molecules, including other compounds, and proteins, in the latest edition of the journal Nucleid Acids Research.

In total, the catalogue includes 16,600 compounds, of which 1,300 contain pharmacological descriptions, and 500,000 interactions that witness the extensive social network that governs the functioning of organisms. The information is available to the entire scientific community via the public FireDB database.

The article's authors, including Paolo Maietta, the first author and a researcher in Valencia's group, point out that: "the creation of FireDB is a reference point for the study of mutations associated with cancer and their biological consequences". According to the researchers, FireDB makes it possible to distinguish the mutations that affect interactions between molecules related to cancer and their effects on the functioning of the cellular machinery.

"For the first time in a single database, this collection of interactions brings together biological information that will be key in understanding the molecular bases of the therapeutic action of drugs, their possible adverse reactions or the creation and development of new therapeutic agents", says Valencia.


'/>"/>

Contact: Nuria Noriega
comunicacion@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert  

Page: 1

Related medicine news :

1. Over 70 new centers to train tomorrows engineers and scientists
2. Scientists Agree: Sleep Less, Get Fat
3. UNC scientists find potential cause for deadly breast cancer relapse
4. Western University cancer researcher teams up with Chinese scientists to study chemotherapy
5. Scientists show how cells protect their DNA from catastrophic damage
6. Scientists far from finish line in understanding anemia in female athletes
7. LSUHSC faculty shares inside knowledge in book to develop nations research scientists
8. Renowned Scientists Join Cure Alzheimer’s Fund’s Search for Alzheimer’s Therapies
9. Scientists fingerprint single cancer cells to map cancers family tree
10. A*STAR scientists bring to light mechanism of drug for infections
11. NSF International Scientists Announce Discovery of New Bacterium, Same Family as E. coli and Klebsiella Pneumonia
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
CNIO scientists create the first large catalog of interactions between drugs and proteins
(Date:10/10/2019)... ... October 10, 2019 , ... AltMed Florida , one of the fastest ... announced the grand opening of its second MÜV™ Medical Cannabis Dispensary on the First ... 4 in Jacksonville Beach. , Located at Beach Plaza Shopping Center at the corner ...
(Date:10/8/2019)... ... October 08, 2019 , ... Safe ... and Fred Meyer, King Sooper, Fry’s, Roundy’s, Smiths and Dillons. , Safe Harvest ... gluten-free. , “Ingredient purity and fresh taste is paramount for us,” says ...
(Date:10/8/2019)... Jose, CA (PRWEB) , ... October 08, 2019 , ... ... with gum disease in San Jose, CA experience relief from this common and treatable ... possible in order to save adults from living with uncomfortable symptoms, including tender and ...
(Date:10/8/2019)... (PRWEB) , ... October 08, 2019 , ... ... company, appointed distinguished innovator, Dr. Jerry Henderson as Chief Medical Officer. Dr. Henderson ... registries analytics platforms. , Dr. Henderson previously served as Chair of both ...
(Date:10/8/2019)... ... October 08, 2019 , ... Smile Brands Inc. has been named one ... Comparably. Smile Brands, a leading dental support organization with nearly 440 affiliated practices across ... Smiles for Everyone®. The Happiness Award is the latest in a series of ...
Breaking Medicine News(10 mins):
(Date:10/19/2019)... (PRWEB) , ... October 18, 2019 , ... Beginnings Treatment ... to act as the official sponsor of the Alcohol and Other Drug Awareness ... to empower students to make informed decisions around alcohol and other drugs through individual ...
(Date:10/17/2019)... (PRWEB) , ... October 17, 2019 , ... ... patients with neuroblastoma, a deadly pediatric nerve cancer, who would otherwise have no ... , Neuroblastoma is one of the most common and aggressive pediatric nervous system ...
(Date:10/15/2019)... , ... October 14, 2019 ... ... LP2 linearity and calibration verification kit, for Roche cobas® analyzers, Order No. ... Apolipoprotein B (Apo-B). Each VALIDATE® LP2 kit, liquid, ready-to-use, and prepared ...
Breaking Medicine Technology: