Navigation Links
CNIO scientists create the first large catalog of interactions between drugs and proteins

The three-dimensional structures of proteins determine how, when and where they bind to drugs and other compounds. In 2012 alone, thousands of structures like this were resolved. Now this mass of information needs to be translated into a biological context that can be used to extract relevant functions from these interactions, as well as significant pharmacological and disease-related effects.

A Spanish National Cancer Research Centre (CNIO) work, led by Alfonso Valencia, Vice-Director of Basic Research, and Michael L. Tress, a researcher on his team, brings together the biggest collection of interactions between pharmacological molecules, including other compounds, and proteins, in the latest edition of the journal Nucleid Acids Research.

In total, the catalogue includes 16,600 compounds, of which 1,300 contain pharmacological descriptions, and 500,000 interactions that witness the extensive social network that governs the functioning of organisms. The information is available to the entire scientific community via the public FireDB database.

The article's authors, including Paolo Maietta, the first author and a researcher in Valencia's group, point out that: "the creation of FireDB is a reference point for the study of mutations associated with cancer and their biological consequences". According to the researchers, FireDB makes it possible to distinguish the mutations that affect interactions between molecules related to cancer and their effects on the functioning of the cellular machinery.

"For the first time in a single database, this collection of interactions brings together biological information that will be key in understanding the molecular bases of the therapeutic action of drugs, their possible adverse reactions or the creation and development of new therapeutic agents", says Valencia.


Contact: Nuria Noriega
Centro Nacional de Investigaciones Oncologicas (CNIO)

Page: 1

Related medicine news :

1. Over 70 new centers to train tomorrows engineers and scientists
2. Scientists Agree: Sleep Less, Get Fat
3. UNC scientists find potential cause for deadly breast cancer relapse
4. Western University cancer researcher teams up with Chinese scientists to study chemotherapy
5. Scientists show how cells protect their DNA from catastrophic damage
6. Scientists far from finish line in understanding anemia in female athletes
7. LSUHSC faculty shares inside knowledge in book to develop nations research scientists
8. Renowned Scientists Join Cure Alzheimer’s Fund’s Search for Alzheimer’s Therapies
9. Scientists fingerprint single cancer cells to map cancers family tree
10. A*STAR scientists bring to light mechanism of drug for infections
11. NSF International Scientists Announce Discovery of New Bacterium, Same Family as E. coli and Klebsiella Pneumonia
Post Your Comments:
Related Image:
CNIO scientists create the first large catalog of interactions between drugs and proteins
(Date:10/13/2017)... ... ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many kids ... sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids excited ... all ages; it is a non-competitive, non-timed event, which is all about having fun ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... giving viewers the lowdown on sciatica in a new episode of "Success Files," ... on current events and innovation and investigates each subject in-depth with passion and ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to ... to save lost souls in the Philippines. “The Journey: From the Mountains to the ... teacher of the Bible. She has taught all ages and currently teaches a class ...
(Date:10/12/2017)... ... October 12, 2017 , ... First ... compliance program management, will showcase a range of technology and learning solutions at ... (NCAL) Convention and Expo to be held October 14–18, 2017 at the Mandalay ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of ... announced today its plans to open a flagship location in Covington, LA at 401 ... Rooms To Go store next to Office Depot in the Holiday Square shopping center. ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... DIEGO , Oct. 12, 2017 AVACEN ... recognized the company with their  2017 New Product Innovation Award ... based on extensive primary and secondary medical device market research ... Medical, through its first-to-market OTC, drug-free pain relief product, the ... unique approach to treating fibromyalgia widespread pain. ...
(Date:10/11/2017)... Texas , Oct. 11, 2017  True ... services, has amplified its effort during National Breast ... about hereditary cancer risks. ... of Clinical Oncology calculated that more than 10 ... have inherited mutations in BRCA1 or BRCA2 and have ...
(Date:10/5/2017)... Ill. , Oct. 5, 2017  In ... Association of Oral and Maxillofacial Surgeons (AAOMS) released ... opioids – to be used as a first-line ... pain. Recognizing ... the AAOMS White Paper "Opioid Prescribing: Acute and ...
Breaking Medicine Technology: