Navigation Links
CNIO scientists create the first large catalog of interactions between drugs and proteins
Date:12/2/2013

The three-dimensional structures of proteins determine how, when and where they bind to drugs and other compounds. In 2012 alone, thousands of structures like this were resolved. Now this mass of information needs to be translated into a biological context that can be used to extract relevant functions from these interactions, as well as significant pharmacological and disease-related effects.

A Spanish National Cancer Research Centre (CNIO) work, led by Alfonso Valencia, Vice-Director of Basic Research, and Michael L. Tress, a researcher on his team, brings together the biggest collection of interactions between pharmacological molecules, including other compounds, and proteins, in the latest edition of the journal Nucleid Acids Research.

In total, the catalogue includes 16,600 compounds, of which 1,300 contain pharmacological descriptions, and 500,000 interactions that witness the extensive social network that governs the functioning of organisms. The information is available to the entire scientific community via the public FireDB database.

The article's authors, including Paolo Maietta, the first author and a researcher in Valencia's group, point out that: "the creation of FireDB is a reference point for the study of mutations associated with cancer and their biological consequences". According to the researchers, FireDB makes it possible to distinguish the mutations that affect interactions between molecules related to cancer and their effects on the functioning of the cellular machinery.

"For the first time in a single database, this collection of interactions brings together biological information that will be key in understanding the molecular bases of the therapeutic action of drugs, their possible adverse reactions or the creation and development of new therapeutic agents", says Valencia.


'/>"/>

Contact: Nuria Noriega
comunicacion@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert  

Page: 1

Related medicine news :

1. Over 70 new centers to train tomorrows engineers and scientists
2. Scientists Agree: Sleep Less, Get Fat
3. UNC scientists find potential cause for deadly breast cancer relapse
4. Western University cancer researcher teams up with Chinese scientists to study chemotherapy
5. Scientists show how cells protect their DNA from catastrophic damage
6. Scientists far from finish line in understanding anemia in female athletes
7. LSUHSC faculty shares inside knowledge in book to develop nations research scientists
8. Renowned Scientists Join Cure Alzheimer’s Fund’s Search for Alzheimer’s Therapies
9. Scientists fingerprint single cancer cells to map cancers family tree
10. A*STAR scientists bring to light mechanism of drug for infections
11. NSF International Scientists Announce Discovery of New Bacterium, Same Family as E. coli and Klebsiella Pneumonia
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
CNIO scientists create the first large catalog of interactions between drugs and proteins
(Date:8/16/2017)... ... August 16, 2017 , ... LabRoots , the leading provider of educational ... is excited to announce Andrew Ly as the winner of the LabRoots Summer Textbook ... , Ly, who is in his third year at the University of California, ...
(Date:8/16/2017)... ... August 16, 2017 , ... Fusion Flix Inc., a Telly Award Winning, Non ... and millions of viewers in a partnership with the Amazon Video Direct Streaming Distribution ... available on Blu Ray disc in 2018. Proceeds will be going to further health ...
(Date:8/16/2017)... ... August 16, 2017 , ... Kaviva , a health ... the healthcare market, with Los Angeles-based AIDS Healthcare Foundation ( AHF ), to ... AHF cares for nearly 800,000 individuals worldwide and is the largest HIV/AIDS organization ...
(Date:8/16/2017)... ... August 16, 2017 , ... ... marketers of high-quality anti-aging skincare solutions, recently announced the launch of two new ... an affordable, yet effective alternative to expensive plastic surgery or in-patient cosmetic dermatological ...
(Date:8/16/2017)... ... August 16, 2017 , ... “Mom, God's Got This: Jamie's Story” is the creation of ... the Lord and has an insatiable appetite for God’s Word. , “I froze between the ... gifts retrieved from packages of oatmeal. I have one to this day on proud display ...
Breaking Medicine News(10 mins):
(Date:7/28/2017)... , July 28, 2017 EnvoyHealth, a Diplomat company, ... a program for CleverCap LITE, a technology designed to ... to deliver innovative health technology solutions and services that ... CleverCap LITE offers medication monitoring ... bottle cover: Records ...
(Date:7/26/2017)... Colo. , July 26, 2017 E.I. ... Guttridge and the Bimini SharkLab to custom design the worlds ... images of sharks in their native habitat. In preparation ... Discovery Channel,s Shark Week, Dr. Guttridge approached EIMI ... take pregnancy diagnosis directly to hammerhead sharks underwater. ...
(Date:7/26/2017)... NEW YORK , July 26, 2017 ... Annual Prix Galien USA Award ... honors, the Prix Galien Award recognizes outstanding biomedical and technology ... To qualify, each candidate must be ... the last five years and demonstrate tremendous potential to impact ...
Breaking Medicine Technology: