Navigation Links
CNIO researchers discover a new therapy that prevents lung cancer growth in mice
Date:8/13/2012

Lung cancer is one of the most aggressive types of cancer and the most common cause of death from this disease worldwide. Despite the progress in the molecular biology of lung cancer achieved in recent years, the mechanisms used by tumor cells to grow and spread throughout the body are not yet completely understood. This lack of information is responsible for the limited range of available therapeutic possibilities and their undesirable side effects.

The Tumour Suppression Group of the Spanish National Cancer Research Centre (CNIO), led by Manuel Serrano, has deciphered one of the molecular pathways behind lung cancer. Using this information, the authors have identified an experimental drug, which blocks lung cancer growth in mice. This work is published today in the scientific journal Cancer Cell.

Standing up to lung cancer

Notch was identified in 2004 as an important oncogene for the development of leukemias and, since then, intense efforts have been devoted to study the role of Notch in other cancers. At the end of the last decade it was found that Notch is also involved in the development of pancreatic and lung cancer.

In this study, Serrano's team has identified the molecular pathways by which Notch regulates cell proliferation in lung cancer. "We have found that this protein cooperates with the Ras oncogene, a key element in the formation of these tumors", states Serrano.

Researchers have also discovered the therapeutic effect of a specific experimental drug which blocks Notch efficiently, named GSIs (Gamma-Secretase Inhibitors). To this end, scientists used genetically modified mice previously developed by Mariano Barbacid, head of the Experimental Oncoloy Group at the CNIO, that faithfully recapitulate human lung cancer. "After 15 days of treatment, lung tumors failed to grow without treatment-related side effects", says Antonio Maraver, the first author of the study.

Co-clinical
'/>"/>

Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert

Page: 1 2

Related medicine news :

1. BUSM researchers part of multi-center study on cardiac amyloidosis
2. BUSM/VA researchers uncover gender differences in the effects of long-term alcoholism
3. Excellence Initiative winner TU München invests in the future: Young researchers
4. Clemson researchers collect and reuse enzymes while maintaining bioactivity
5. Healthcare researchers recognized at SingHealth Duke-NUS Scientific Congress 2012
6. Northwestern researchers investigate treatment for tumor cells in spinal fluid
7. Vanderbilt researchers find proteins may point way to new prostate cancer drug targets
8. MDC researchers develop new approach to treat acute liver failure
9. Breast Cancer Charity Overstates Value of Mammograms: Researchers
10. Boston University researchers expand synthetic biologys toolkit
11. Global health researchers urge integrating de-worming into HIV care in Africa
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... 28, 2014 Testimony began this ... a transvaginal mesh lawsuit ( http://www.transvaginalmeshlawsuithelp.com/ )involving ... LLP reports. Court documents pending in the U.S. ... that the case was filed on behalf of ... surgeries, allegedly due to vaginal mesh complications associated ...
(Date:8/28/2014)... (PRWEB) August 28, 2014 The Governor ... Microcredit Summit at a press conference; this event ... with the Ministry of Economy through the National Microenterprise ... from September 2nd to the 5th at the Convention ... , “It is a great responsibility for Yucatan to ...
(Date:8/28/2014)... Kirklyn Smith, an office manager for EzCOI.com , is ... by walking 5,000 miles in a single year without ever ... thousands of individual stories of TrekDesk treadmill desk users across ... than the others. , Kirklyn has launched a website that ... range of 54,823 steps (presumably on an off day) to ...
(Date:8/28/2014)... August 28, 2014 Bank lending to the ... year, down by 0.13% in real terms, and continuing to ... new study by UHY, the international accountancy network. , UHY ... businesses in particular, the credit crunch lingers on. , UHY ... the last year have been wiped out by inflation. Over ...
(Date:8/28/2014)... of sleep not only puts teens at risk for poor ... researchers warn. The study authors analyzed data collected from ... 21. Nearly one-fifth of them got less than six hours ... this group was 20 percent more likely to be obese ... hours of sleep per night at age 16, the investigators ...
Breaking Medicine News(10 mins):Health News:Transvaginal Mesh Lawsuit News: Testimony Begins in Second Federal Ethicon Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuit News: Testimony Begins in Second Federal Ethicon Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Transvaginal Mesh Lawsuit News: Testimony Begins in Second Federal Ethicon Bellwether Trial, Bernstein Liebhard LLP Reports 4Health News:Governor of the State of Yucatan presents the 17th Microcredit Summit 2Health News:Governor of the State of Yucatan presents the 17th Microcredit Summit 3Health News:There are many reasons why Americans' exercise levels have declined - Meet an executive that refuses to sit still with his TrekDesk Treadmill Desk even in a sedentary job 2Health News:UHY Study Shows Bank Lending In USA Falling Behind G7 Peers 2Health News:UHY Study Shows Bank Lending In USA Falling Behind G7 Peers 3Health News:UHY Study Shows Bank Lending In USA Falling Behind G7 Peers 4Health News:UHY Study Shows Bank Lending In USA Falling Behind G7 Peers 5Health News:UHY Study Shows Bank Lending In USA Falling Behind G7 Peers 6Health News:UHY Study Shows Bank Lending In USA Falling Behind G7 Peers 7Health News:Less Sleep in Teen Years Tied to More Pounds at 21 2
... new study, a serious form of cancer that arises in ... normally serve as ‘scouts’ for the immune system. ... virus (EBV), which is usually kept under check by the ... control is lost and the transplanted organ may be rejected. ...
... characterized by pain and tenderness in the jaw muscles ... ,TMD is a problem for millions of Americans whose ... open-joint surgery. Whole system naturopathic care as a treatment ... of a new study involving 160 women in the ...
... a research conducted to study the link between work-related ... real or threatened violence at workplace run a major ... showed that the magnitude of the risk was in ... ,The findings of the study have been published ...
... of just a few puffs of cigarette that is capable ... that the amount of nicotine present in a single puff ... receptors and 3 puffs can occupy nearly 70% of these ... the receptors are filled up. But this feeling of satisfaction ...
... has now risen to 19 from 17. The official ... encephalitis was spreading rapidly.// ,Health officials in ... infections had emerged since July 13. Encephalitis causes the ... left untreated can be fatal. In China, health authorities ...
... The calories that contribute to ill health are loaded in ... consequentially off the lives of many // , who are ... with, the ideal thing would be to ensure the promotional ... that people are dished out the right information about healthy ...
Cached Medicine News:Health News:Deficient 'Scout Cells' Causes Cancer in Transplant Patients 2Health News:Deficient 'Scout Cells' Causes Cancer in Transplant Patients 3Health News:Naturopathic Care Proves Beneficial for TMD Pain 2Health News:Work-Related Violence Increases Risk Of Depression 2Health News:Imaging study affords renewed thrust on smoking cessation treatments 2Health News:Imaging study affords renewed thrust on smoking cessation treatments 3
(Date:8/28/2014)... 2014  Seres Health, a clinical-stage therapeutics company ... human microbiome, announced today that Dr. David ... and Chief Scientific Officer, will be presenting at ... Chemotherapy (ICAAC). The presentation will highlight the scientific ... of bacterial spores derived from the human microbiome, ...
(Date:8/28/2014)... 2014   Venaxis, Inc.  (Nasdaq:  APPY), an ... clearance for and commercializing its CE Marked APPY ... identifying children, adolescent, and young adult patients in the ... today announced it will present at three upcoming investor ... Global Investment Conference being held in New ...
(Date:8/28/2014)... PLYMOUTH MEETING, Pa. , Aug. 28, 2014 ... surgical community, patients, and media, both for the ... to patient safety. The quick deployment of surgical ... new technology are prompting facilities to evaluate their ... for the entire surgical team.    ...
Breaking Medicine Technology:Seres Health to Present Clinical Findings at ICAAC 2014 Conference 2Venaxis to Present at September Investor Conferences 2Venaxis to Present at September Investor Conferences 3Surgical Robot Risk and Safety: ECRI Institute and Hartford Hospital Launch New Education Series 2Surgical Robot Risk and Safety: ECRI Institute and Hartford Hospital Launch New Education Series 3Surgical Robot Risk and Safety: ECRI Institute and Hartford Hospital Launch New Education Series 4Surgical Robot Risk and Safety: ECRI Institute and Hartford Hospital Launch New Education Series 5
... Delcath Systems, Inc. (Nasdaq: DCTH ) today ... of Directors. Dr. Contag is a proven corporate executive with ... , (LOGO: http://www.newscom.com/cgi-bin/prnh/20081118/NY46990LOGO ... Cobalt Technologies, Inc. in 2006 and served as CEO. Prior ...
... & Alzheimer,s Disease , , ... today announced that its researchers have uncovered a new ... a potential target for developing novel therapeutics for intervention ... Institute,s Pancham Bakshi, Ph.D., is detailed in the ...
Cached Medicine Technology:Delcath Adds Dr. Pamela R. Contag to Its Board of Directors 2Delcath Adds Dr. Pamela R. Contag to Its Board of Directors 3Roskamp Institute Identifies New Class of Drugs to Treat Alzheimer's Disease 2Roskamp Institute Identifies New Class of Drugs to Treat Alzheimer's Disease 3
Lyphochek Urine Bone Markers Control is a bilevel human urine based control designed to monitor tests for urinary markers of osteoporosis management and bone resorption....
... Control is designed to ... significant range of those ... during fertility or pregnancy ... hCG-Beta Subunit levels allow ...
... provides the clinical laboratory with the ... for monitoring immunoassay and therapeutic drug ... separate controls. Made from human serum ... suitable for most methods and is ...
Lyphochek Immunology Plus Control is an assayed control for monitoring chemistry procedures that test for autoimmune, anemic, malignant, hepatic and nephrotic-disease states. Available in two levels....
Medicine Products: