Navigation Links
CNIO researchers describe new functions of cohesin relevant for human disease
Date:5/3/2012

Cohesin is a ring-shaped protein complex involved in the spatial organization of the genome and in mitotic chromosome structure. Vertebrate somatic cells have two versions of cohesin that contain either SA1 or SA2, but their functional specificity has been largely ignored. Researchers of the Spanish National Cancer Research Centre (CNIO) under the direction of Ana Losada have identified new functions of cohesin SA1 that are relevant for two human diseases, cancer and Cornelia de Lange Syndrome (CdLS). These results are published in two papers that appear this week back-to-back in EMBO Journal.

The first study shows that SA1 is required for efficient duplication of chromosome ends, the telomeres. In its absence, aberrant telomere structures hinder chromosome segregation during cell division and aneuploid cells (i.e., with an incorrect number of chromosomes) are generated. This aneuploidy likely contributes to accelerate the onset of tumourigenesis in SA1 deficient mice. The appearance of certain types of pancreatic tumours, extremely rare in mice, is particularly striking. This mouse model may turn out to be a very useful tool for the study of pancreatic cancer.

The second study reports for the first time a precise map of the distribution of cohesin SA1 and cohesin SA2 along the mouse genome. Moreover, it uncovers an essential role of cohesin SA1 in the regulation of gene expression during embryonic development. Lack of cohesin SA1 alters the transcription of genes involved in biological processes related to CdLS. This developmental disorder affects 1:30,000 newborns and is characterized by growth and mental retardation and multiple organ abnormalities. The study offers new clues to understand the origin of the pathologies observed in CdLS patients.

"This work represents an important step towards better understating the role of cohesin in such relevant human diseases as cancer and CdLS", comment Silvia Remeseiro and Ana Cuadr
'/>"/>

Contact: Juan J. Gomez
juanj.gomez@cnio.es
34-917-328-000-4060
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Biomedical researchers receive Hartwell Foundation awards
2. Kessler Foundation researchers present at first International Congress on Cognition in MS
3. Researchers gain better understanding of mechanism behind tau spreading in the brain
4. Moffitt Cancer Center researchers identify drivers of sarcoma growth and survival
5. Researchers determine vitamin D blood level for reducing major medical risks in older adults
6. Researchers creating designer lymph nodes based on Moffitts Total Cancer Care initiative
7. Moffitt researchers find adolescents with cancer concerned about their future reproductive health
8. Moffitt Cancer Center researchers working at frontiers of melanoma research
9. Moffitt Cancer Center researchers: Quality of life as important as quantity of life
10. UCLA researchers combat global disease with a cell phone, Google Maps and a lot of ingenuity
11. Spinal cord injury researchers win Apple Award for article on niacin for dyslipidemia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... Strongly influenced by their self-interest, humans ... are no consequences, researchers in Georgia State University’s ... could imply that humans are less concerned than ... said. Their findings are published in the journal ... unfairness is affected by their self-interest, indicating the ...
(Date:8/21/2014)... Recently, Skmen.com, a distinguished garment supplier, has updated its product ... dresses . From today until August 31, all clients can ... they are shopping at the company’s online store. , ... the newest quality standards; they are guaranteed to be fashionable ... ladies can also access the other cheap items in its ...
(Date:8/21/2014)... DoudouneCanadienneGoosePasCher.fr, one of the most popular suppliers ... its new selection of Trillium Parkas for 2014. Moreover, ... these fashionable and comfortable items are available at discounted ... last until September 01. , The CEO says ... Canada Goose Trillium Parkas for new and old ...
(Date:8/21/2014)... 22, 2014 BambooIndustry.com is an internationally ... company has recently unveiled its new collection of elegant ... made for customers who are looking for high quality ... are offered with great savings (up to 29 percent ... access these cheap products. , The company’s bamboo ...
(Date:8/21/2014)... the University of Michigan,s Transplant Center was able to ... for transplant by about 20 percent. , The results ... detail the impact of more than 10 years of ... quality and viability of organs donated after circulatory determination ... number of donated organs available, so the use of ...
Breaking Medicine News(10 mins):Health News:Influenced by Self-Interest, Humans Less Concerned About Inequity To Others, Researchers Find 2Health News:Influenced by Self-Interest, Humans Less Concerned About Inequity To Others, Researchers Find 3Health News:Charming Girls’ Casual Dresses Now Released by Distinguished Garment Company Skmen.com 2Health News:Fashionable And Comfortable Canada Goose Trillium Parkas For Sale At DoudouneCanadienneGoosePasCher.fr 2Health News:Buy Elegant Bamboo Floorings from Internationally Well-known Supplier BambooIndustry.com 2Health News:Extracorporeal support can significantly increase number of organs for transplant 2
... 7th International Symposium on GnRH Analogs in Cancer ... development of fertility drugs. Organon scientists have succeeded ... a hybrid subunit, which extends FSH's active life. ... longer active life will mean fewer injections for ...
... version of Annals of Internal Medicine has suggested that the ... boost energy, is posing a threat to people's health and ... to the supplement. The study used data gathered by the ... of the total calls received, an// estimated 80 per cent ...
... van den Dolder at the University of Nijmegen has shown ... with the help of specially prepared titanium mesh and bone ... bone fracture in a rat. They allowed bone marrow cells ... being stimulated by the bone// marrow cells. They found that ...
... of Public Health now reveals that caregiving may be associated ... who care for a disabled or ill spouse have an ... from a long-running Nurses' Health Study, which had collected data ... between 46 and 71. They found that those who devoted ...
... PNAS that understanding and treating cholesterol-related illnesses in humans ... receptor in the cells of mice that protects them ... of cerebrotendinous xanthomatosis (CTX), a rare and often fatal ... Pregnane X receptor (PXR)// is present in humans but ...
... decades now, about having spotless white teeth and a ... problem that is caused by aging and colored molecules ... people used corrosive nitric acid, which bleached teeth white ... destroyed them! However, dentists have now discovered many easy ...
Cached Medicine News:Health News:New fertility drug development techniques by Organon 2Health News:Bones repair themselves with bone marrow cells 2
(Date:8/21/2014)... , Aug. 21, 2014 /PRNewswire-iReach/ -- ScriptPro ... Alliance (HITRUST) under its Common Security Framework (CSF). ... Security and Privacy Manager, "We appreciate this rigorous, ... of commitment that this certification signifies. Our business ... ABOUT THE CSF CERTIFICATION PROCESS: ScriptPro,s internal ...
(Date:8/21/2014)... 2014  Henry Schein, Inc. (NASDAQ: HSIC ), ... to office-based dental, animal health and medical practitioners, announced today ... September: , September 4, 2014 – Baird 2014 ... 12:50 p.m. ET , September 8, 2014 – ... York , NY at 1:25 p.m. ET ...
(Date:8/21/2014)... 21, 2014  The board of directors of VirtualScopics, ... of clinical trial imaging solutions, today announced that ... officer, effective immediately.  Mr. Groff has held the role ... joined VirtualScopics in January 2006 as an accounting manager ... "When the board of VirtualScopics asked Jim to ...
Breaking Medicine Technology:ScriptPro Achieves HITRUST Certification 2Henry Schein To Present At Two Investor Conferences In September 2VirtualScopics, Inc. Names James Groff Chief Financial Officer 2VirtualScopics, Inc. Names James Groff Chief Financial Officer 3VirtualScopics, Inc. Names James Groff Chief Financial Officer 4
... YORK, May 19, 2011 Reportlinker.com announces ... available in its catalogue: ... http://www.reportlinker.com/p0503653/Pharmaceutical-Management-of-Obesity-Technical-Insights.html?utm_source=prnewswire&utm_medium=pr&utm_campaign=Drug_and_Medication ... a lot of research and product development ...
... 2011 Genomic Health, Inc. (Nasdaq: GHDX ... from ten separate studies at the American Society of ... 2011 at McCormick Place in Chicago.  The company markets ... which is clinically validated to predict chemotherapy benefit as ...
Cached Medicine Technology:Reportlinker Adds Pharmaceutical Management of Obesity (Technical Insights) 2Genomic Health Announces Ten Studies Covering Breast, Colon and Prostate Cancers Accepted for Presentation at the American Society of Clinical Oncology (ASCO) Annual Meeting 2Genomic Health Announces Ten Studies Covering Breast, Colon and Prostate Cancers Accepted for Presentation at the American Society of Clinical Oncology (ASCO) Annual Meeting 3Genomic Health Announces Ten Studies Covering Breast, Colon and Prostate Cancers Accepted for Presentation at the American Society of Clinical Oncology (ASCO) Annual Meeting 4Genomic Health Announces Ten Studies Covering Breast, Colon and Prostate Cancers Accepted for Presentation at the American Society of Clinical Oncology (ASCO) Annual Meeting 5Genomic Health Announces Ten Studies Covering Breast, Colon and Prostate Cancers Accepted for Presentation at the American Society of Clinical Oncology (ASCO) Annual Meeting 6Genomic Health Announces Ten Studies Covering Breast, Colon and Prostate Cancers Accepted for Presentation at the American Society of Clinical Oncology (ASCO) Annual Meeting 7
Attain Left-heart Lead Delivery Systems. Medtronic offers left-heart lead delivery systems to assist with accessing the coronary sinus (cs)....
Attain Left-heart Lead Delivery Systems. Medtronic offers left-heart lead delivery systems to assist with accessing the coronary sinus (cs)....
Attain™ Left-heart Lead Options to Fit Your Patient's Anatomy. Navigate moderately to greatly angled veins with high tortuosity....
Attain LV Leads. Navigate minimally angled veins with little to moderate tortuosity....
Medicine Products: