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CNIO experts discover the genomic origin of telomere protectors
Date:9/3/2014

m chromosome 9.

"Once TERRA were transcribed, we found that they associated with the telomeres that protect the 20 murine chromosomes [not simultaneously], and not just with their telomere of origin", says Lpez de Silanes. The researcher emphasises that this union "is important for the ultimate protection of chromosomes because when TERRA levels fall using molecular tools, damage is caused in the telomere".

The discovery of the genomic origin of TERRA will allow us to design molecular and genetic tools in order to study their functional role in the normal development of the mouse, as well as their role in illnesses. "We are already generating new mouse strains that contain modifications in the regions TERRAs originate from, which will set the stage for understanding the role of these molecules and advance the frontier of knowledge regarding telomeres", says Lpez de Silanes.


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Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert

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