Navigation Links
CNIC researchers find a possible treatment for one of the main symptoms of premature aging disease
Date:6/17/2013

HGPS is a rare genetic disease that affects one in every 4-8 million births. The disease is caused by a spontaneous mutation in one of the two copies (alleles) of the gene LMNA, which codes for lamin A, a protein important for the integrity and function of the envelope surrounding the cell nucleus. The mutation causes incorrect processing of the messenger RNA for lamin proteins, resulting in the synthesis of an anomalous protein, called progerin.

The new study, published in the leading cardiovascular research journal Circulation, identifies a possible treatment to block the deposition of calcium in arterial wall. This calcification greatly increases the risk of cardiovascular disease, and most progeria patients die of a heart attack or stroke at an average age of just 13 years.

The researchers, led by Dr. Vicente Andrs, director of the Molecular and Genetic Cardiovascular Pathophysiology group at the CNIC, describe the mechanisms that cause vascular calcification in a mouse model of HGPS that recapitulates the main symptoms of the human disease. The study was conducted in close collaboration with the team at the Universidad de Oviedo led by world-leading progeria expert Dr. Carlos Lpez-Otn.

The authors show that the aortas and blood of 'progeric' mice accumulate smaller quantities than healthy mice of extracellular pyrophosphate, a potent inhibitor of vascular calcification. This is due to two main reasons. First, due to a defect in their mitochondria, these mice produce lower amounts of the source of pyrophosphate, ATP. Second, the progeric mice have a higher than normal activity of alkaline phosphatase, the enzyme responsible for degrading pyrophosphate.

Dr. Andrs' team has demonstrated that chronic treatment with pyrophosphate inhibits the deposition of calcium in the arteries of mice with the disease.

The next step toward translating this finding to humans will be to confirm that the same mechanism also exists in children
'/>"/>

Contact: AInhoa Iriberri
airiberri@cnic.es
34-610-295-556
Centro Nacional de Investigaciones Cardiovasculares
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers explode the myth about running injuries
2. Mount Sinai Researchers Succeed in Programming Blood Forming Stem Cells
3. Researchers find low level of patient involvement in medical decision-making in Peru
4. Yale researchers unravel genetics of dyslexia and language impairment
5. Mount Sinai researchers succeed in programming blood forming stem cells
6. Researchers gain new molecular-level understanding of the brains recovery after stroke
7. Researchers identify a new mechanism of TB drug resistance
8. Mount Sinai researchers provide 1st prospective characterization of a genetic subtype of autism
9. Obesity can be predicted from infancy, CWRU researchers find
10. Quality-of-life issues need to be addressed for CML patients, Moffitt researchers say
11. With new $1.7 million grant, U-M, Johns Hopkins researchers will develop dementia treatment tool
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2014)... CA (PRWEB) August 31, 2014 The ... healthcare provider specializing in menopause is expert ... lifestyle expectations and relief from uncomfortable symptoms with the ... time complementary therapies offer a variety of alternative treatments ... women. While these treatment options may fall outside of ...
(Date:8/30/2014)... Saturday 30 August 2014: A new method ... external defibrillators (AEDs) was presented at ESC Congress today ... predictive method, Paris needs 350 AEDs located in public ... arrest (OHCA). , Dr Dahan said: "Out of hospital ... an annual incidence ranging between 50 and 100 per ...
(Date:8/30/2014)... According to the latest review on DailyGossip.org, this is the ... health. It seems that the method is so popular nowadays ... patients from all over the world. , The program ... will not only eliminate acne forever, but will also help ... program unique among other methods of curing candida is the ...
(Date:8/30/2014)... Zensah®, the leader in compression technology and comfort, has seen ... within golf and tennis. Golfers and tennis players are able ... using the compression elbow sleeve to help treat elbow tendonitis ... causes pain on the inner side of your elbow, where ... bump on the inside of your elbow. The pain may ...
(Date:8/30/2014)... The Truth about Six Pack Abs is a ... users some shocking foods that can burn belly fat, unique ... as well as some motivation secrets for successful fitness. , ... one unique trick that can help users reduce junk-food cravings. ... people might think, cardio exercise routines are not the best ...
Breaking Medicine News(10 mins):Health News:A Look at Complementary Therapies and Alternative Medicine for National Menopause Awareness Month 2Health News:A Look at Complementary Therapies and Alternative Medicine for National Menopause Awareness Month 3Health News:A Look at Complementary Therapies and Alternative Medicine for National Menopause Awareness Month 4Health News:A Look at Complementary Therapies and Alternative Medicine for National Menopause Awareness Month 5Health News:New method predicts optimal number and location of AEDs 2Health News:Acne No More Review Reveals Unusual Tip to Eliminate Acne Permanently 2Health News:Relieve Golfers and Tennis Elbow Pain with the Zensah® Compression Elbow Sleeve 2Health News:Truth about Six Pack Abs Review Reveals Unique Method to Eliminate Stubborn Stomach Fat 2
... ... laden 53, tractor trailers becomes the nation,s first self-contained, portable, maximum output growing system ... Francisco,s International Cannabis & Hemp Expo. , ... Oakland, CA (PRWEB) -- Irvine, CA based agriculture solutions provider ...
... ... (SMNA) visualizes, interprets and optimizes the complex network patterns and flows of social media, ... and enterprise collaboration. The Social Media Network Analysis workshop is practical, hands-on, low-cost ... ...
... ... ... A recent survey by BusinessProcessGuidance.com of 286 senior executives found that the workload for knowledge ... the study’s key findings: knowledge workers not only have more to do, but the nature ...
... ... Physical Therapy, ,places first in women’s division of triathlon, , ... New York, NY (PRWEB) April 15, 2010 -- Allison ... therapist at NY Sports Medicine & Physical Therapy, placed first in the women’s division ...
... ... today announce a partnership agreement to provide customers with an advanced BlackBerry® smartphone paging ... smartphone from Research In Motion (RIM) (Nasdaq: RIMM) via their current pager number and ... ...
... A study in the April 15 issue of the Journal ... before bedtime has only a mild effect on the sleep of ... video game it took adolescents a median of 7.5 minutes to ... it took them to fall asleep after passively watching a documentary ...
Cached Medicine News:Health News:The Medical Marijuana Industry Finds an Outside-the-Box Solution, "Inside the Box" With GrowOp Technology 2Health News:The Medical Marijuana Industry Finds an Outside-the-Box Solution, "Inside the Box" With GrowOp Technology 3Health News:Social Media Network Analysis Workshop 2Health News:Social Media Network Analysis Workshop 3Health News:BusinessProcessGuidance.com Survey Exposes a Knowledge Worker Productivity Gap 2Health News:Physical Therapist Wins Nautica South Beach Triathlon 2Health News:Physical Therapist Wins Nautica South Beach Triathlon 3Health News:Indiana Paging Network and Onset Technology Partner to Deliver Paging Messages to Blackberry Smartphones 2Health News:Indiana Paging Network and Onset Technology Partner to Deliver Paging Messages to Blackberry Smartphones 3Health News:Playing a video game before bedtime has only a mild effect on adolescent sleep 2Health News:Playing a video game before bedtime has only a mild effect on adolescent sleep 3
(Date:8/29/2014)... 29, 2014 Thoratec Corporation (NASDAQ: ... support therapies to save, support and restore failing hearts, ... Morgan Stanley Global Healthcare Conference on Wednesday, September 10. ... Chief Executive Officer, will provide an update on the ... a.m., Pacific Daylight Time).   A webcast ...
(Date:8/29/2014)... 2014 According to a ... Extraction type (SFE, Cold Pressed, Organic Solvent, & Others), ... Food Supplements, Fragrance, & Others) - Global Trends & ... segments the Amaranth Seed Oil Market with an ... terms of value. The Amaranth Seed Oil Market ...
(Date:8/29/2014)... August 29, 2014 According ... Product & Services (Equipment, Reagent, Primer, Probe, Custom ... PCR, QPCR, Gene Synthesis, NGS, DNA, RNAi) - ... global Oligonucleotide Synthesis Market is expected to reach ... 2014, growing at a CAGR of 9.8% from ...
Breaking Medicine Technology:Amaranth Seed Oil Market worth $700.6 Million by 2019 2Amaranth Seed Oil Market worth $700.6 Million by 2019 3Amaranth Seed Oil Market worth $700.6 Million by 2019 4Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 3Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 4
... Innocoll, Inc., a privately-held biopharmaceutical company, announced that ... first of two ongoing U.S. phase 3 clinical ... Technologies Ltd, to investigate CollaRx(R) GENTAMICIN SURGICAL IMPLANT ... is being conducted at approximately 50 hospital sites ...
... likely to need emergency room treatment or hospitalization ... a series to examine factors impacting patient response ... Results of a new study presented at the ... Asthma, Allergy and Immunology (AAAAI) show dramatic reductions ...
Cached Medicine Technology:Innocoll Announces Dosing of Last Patient in US Phase 3 Clinical Trial to Investigate GENTAMICIN SURGICAL IMPLANT for Prevention of Surgical Site Infections in Cardiac Surgery Patients 2Innocoll Announces Dosing of Last Patient in US Phase 3 Clinical Trial to Investigate GENTAMICIN SURGICAL IMPLANT for Prevention of Surgical Site Infections in Cardiac Surgery Patients 3New Study Suggests Cholesterol-Lowering Statins Reduce Severe Asthma Attacks that Result in Hospitalizations and Emergency Room Visits 2New Study Suggests Cholesterol-Lowering Statins Reduce Severe Asthma Attacks that Result in Hospitalizations and Emergency Room Visits 3New Study Suggests Cholesterol-Lowering Statins Reduce Severe Asthma Attacks that Result in Hospitalizations and Emergency Room Visits 4
Cocoon Disposable Patient Warming Blankets are specially designed to prevent hypothermia and maintain normothermia in your patients. The soft warm coloured material is strong and resists tearing and ...
The design of the large pediatric underbody blanket conveniently warms the large child or small adult patient while allowing full access for surgeons and staff....
This blanket gently surrounds the child with temperature-controlled air. Use one or both of the enclosed clear plastic drapes to keep warmed air near the skin....
The sterile cardiac blanket is utilized during surgical procedures that require access to the upper half of the body. Warms groin area while providing easy access to the area through a perforated ope...
Medicine Products: