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CIHR team grant to fund multidisciplinary breast cancer survivorship studies
Date:7/27/2010

ture death.

"Our team will look at breast cancer recurrence, death from breast cancer as well as overall survival and whether physical activity and health-related fitness cardio-respiratory fitness, muscular strength, body composition - are independent predictors of recurrence of the disease and survival," says Courneya.

For the five-year study, researchers will be recruiting 1500 women newly-diagnosed with breast cancer through the Tom Baker Cancer Centre in Calgary and the Cross Cancer Institute in Edmonton, and the study is set to begin early in 2011. "We have a system set up with the medical oncologists at these centres and all women eligible for the study, up to age 75, will be approached by them, to see if they want to participate," he says.

Besides the major studies, Courneya says, there are opportunities for sub-group analysis, with a large research cohort. "These analyses might include looking at the link between fitness and disease outcomes based on disease stage, or we could look at some of the molecular markers in the cancer cells such as estrogen receptor positive or estrogen receptor negative cancer, for example.

"We may find that fitness is a strong predictor but only for people who have estrogen receptor positive breast cancer. In the sub-groups we can examine if it's the same across all patients or if there are certain medical and demographic factors that make exercise a strong link for some groups and potentially no link for other groups, like estrogen-receptor negative breast cancer. Maybe we'll find that exercise doesn't reduce the risk of recurrence with that type of cancer," says Courneya.

"We can look at and determine what role exercise is playing depending on other medical co-morbidities or depending on your fitness level at the time of diagnosis and those types of things. Then you can give more targeted recommendation about what the best bang for the buck might be in terms of an exercise prescri
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Contact: Jane Hurly
jane.hurly@ualberta.ca
780-492-6821
University of Alberta - Faculty of Physical Education and Recreation
Source:Eurekalert

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