Navigation Links
CIHR team grant to fund multidisciplinary breast cancer survivorship studies

Over the next five years, a diverse, multi-disciplinary team of researchers led by Dr. Kerry Courneya of the University of Alberta and Dr. Christine Friedenreich of Alberta Health Services will conduct a series of five large research projects to probe the impacts of physical activity on breast cancer thanks to a $2.5 million team grant over five years from the Canadian Institutes of Health Research (CIHR).

Courneya's team is one of just four across Canada to be awarded a CIHR team grant, and the only team from the University of Alberta to do so.

A Canada Research Chair in Physical Activity and Cancer since 2004, Courneya has been making breakthroughs in the field of physical activity and cancer field for over a decade. This grant gives his team the opportunity to take their work down new paths and using different approaches thanks to a large, diverse research cohort. Courneya will be working in concert with researchers from the U of A, University of Calgary, Athabasca University and Alberta Health Services whose expertise spans behavioural medicine, psychology, epidemiology, endocrinology, medical oncology, exercise physiology, physiotherapy and bio-statistics.

"The really novel aspect of this study is the link between physical activity and fitness, and disease outcomes. There has been limited research examining those outcomes. Women who survive breast cancer are at greater risk for breast cancer recurrence, second cancers, cardiac dysfunction, weight gain, bone loss, lymphedema, joint pain; they complain of cognitive dysfunction, menopausal symptoms, fatigue; some report psychosocial distress.

The five research projects will focus on the potential role of physical activity and health-related fitness in facilitating treatment completion, alleviating treatment side effects, hastening recovery after treatments, improving long term quality of life and reducing the risks of disease recurrence, other chronic diseases, and premature death.

"Our team will look at breast cancer recurrence, death from breast cancer as well as overall survival and whether physical activity and health-related fitness cardio-respiratory fitness, muscular strength, body composition - are independent predictors of recurrence of the disease and survival," says Courneya.

For the five-year study, researchers will be recruiting 1500 women newly-diagnosed with breast cancer through the Tom Baker Cancer Centre in Calgary and the Cross Cancer Institute in Edmonton, and the study is set to begin early in 2011. "We have a system set up with the medical oncologists at these centres and all women eligible for the study, up to age 75, will be approached by them, to see if they want to participate," he says.

Besides the major studies, Courneya says, there are opportunities for sub-group analysis, with a large research cohort. "These analyses might include looking at the link between fitness and disease outcomes based on disease stage, or we could look at some of the molecular markers in the cancer cells such as estrogen receptor positive or estrogen receptor negative cancer, for example.

"We may find that fitness is a strong predictor but only for people who have estrogen receptor positive breast cancer. In the sub-groups we can examine if it's the same across all patients or if there are certain medical and demographic factors that make exercise a strong link for some groups and potentially no link for other groups, like estrogen-receptor negative breast cancer. Maybe we'll find that exercise doesn't reduce the risk of recurrence with that type of cancer," says Courneya.

"We can look at and determine what role exercise is playing depending on other medical co-morbidities or depending on your fitness level at the time of diagnosis and those types of things. Then you can give more targeted recommendation about what the best bang for the buck might be in terms of an exercise prescription."

Courneya says the true value of the team grant is the legacy of research projects it will spawn.

"The real goal of our CIHR team grant is to build this cohort so we have a beautiful resource, a living laboratory, 1500 women with all the gold standard assessments of exercise and health-related fitness tracked over many years and followed for all these disease outcomes.

"And once you establish that, there are an endless number of questions future students and academics could potentially look at."


Contact: Jane Hurly
University of Alberta - Faculty of Physical Education and Recreation

Related medicine news :

1. $9M NIH grant renewal awarded to Case Western Reserve/UHCMC Center for AIDS Research
2. 5 awarded ASTRO research grants
3. Lu receives grant from Research to Prevent Blindness organization
4. Shao wins grant from Research to Prevent Blindness organization for dry eye research
5. Scripps Research scientists share $2 million in Florida state research grants
6. UCSD researchers receive $2.5 million in new stem cell grants
7. Athletes for Hope Awarded $2 Million Grant by Kellogg Foundation
8. RWJF and Pew award 6 grants to examine the impact of policy on peoples health
9. Susan G. Komen for the Cure awards grant to Lombardis V. Craig Jordan
10. US Patent Granted To Chrono Therapeutics Inc. For Its Chrono-Pharmacological Drug Delivery Systems And Applications
11. Einstein awarded NIH grant to study drug-resistant TB
Post Your Comments:
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... June 19, ... the dangers associated with chronic pain and the benefits of holistic treatments, Serenity ... who are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension ... that it will receive two significant new grants to support its work to ... its 25th anniversary by recognizing patients, medical professionals and scientists for their work ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. ... accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, ... and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic ...
(Date:6/24/2016)... ... , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business ... to $12 an hour by 2020 and then adjusting it yearly to increase at the ... minimum wage, assure the wage floor does not erode again, and make future increases more ...
(Date:6/24/2016)... Norcross, Georgia (PRWEB) , ... June 24, 2016 ... ... Year” awards today at the Clinical Decision Making in Emergency Medicine conference in ... who have authored journal articles published in Emergency Medicine Practice and ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016 Dehaier Medical Systems Ltd. ... which develops, markets and sells medical devices and wearable ... signed a strategic cooperation agreement with Hongyuan Supply Chain ... Chain") on June 20, 2016, to develop Dehaier,s new ... cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s sales ...
(Date:6/24/2016)... , June 24, 2016   Pulmatrix, Inc ., ... developing innovative inhaled drugs, announced today that it was ... Investments reconstituted its comprehensive set of U.S. and ... "This is an important milestone for Pulmatrix," said Chief ... shareholder awareness of our progress in developing drugs for ...
(Date:6/23/2016)... 2016 Research and Markets has announced ... Forecast to 2022" report to their offering. ... the patients with kidney failure, it replaces the function of ... patient,s blood and thus the treatment helps to keep the ... balance. Increasing number of ESRD patients & ...
Breaking Medicine Technology: