Navigation Links
CHOP experts collaborate in gene survey of childhood brain cancer; intriguing clues found
Date:12/16/2010

Pediatric cancer researchers at The Children's Hospital of Philadelphia contributed important expertise to a new landmark study of medulloblastoma, a type of brain tumor typically found in children. The large multicenter study defines the genetic landscape of this cancer, and holds intriguing clues to gene changes on signaling pathways that may become fruitful targets for future therapies.

The most common cancerous brain tumor in children, medulloblastoma is, fortunately, rare. However, it causes significant mortality, and survivors may suffer serious long-term side effects from treatment, so less toxic, more effective therapies are sorely needed.

The study appears online today in the journal Science. Collaborators from three countries and more than a dozen institutions co-authored the research, which was led by three scientists from Johns Hopkins University and the Howard Hughes Medical Institute: Bert Vogelstein, M.D., Kenneth Kinzler, Ph.D., and Victor Velculescu, M.D., Ph.D.

The researchers used recent innovations in gene-sequencing and informatics technology to analyze the whole exome (all the genes known to code for proteins) of medulloblastoma tumors. "This is the first application of whole-exome DNA sequencing analysis to a solid pediatric tumor, and there were encouraging results," said co-author Tom Curran, Ph.D., whose laboratory at The Children's Hospital of Philadelphia focuses on finding new treatments for medulloblastoma.

Curran added, "The study team found that the number of mutations in pediatric medulloblastoma tumors is five to ten times fewer than in adult medulloblastoma tumors. This suggests that, compared to adult tumors, pediatric tumors may respond better to drugs that target the genes and pathways altered by mutations that drive cancer progression. This is a hopeful finding."

In addition to detecting gene alterations previously found in medulloblastoma, such as mutations in the Hedgehog and Wnt signaling pathways, the current study also identified new and unexpected mutations in the MLL2 and MLL3 genes, genes not previously implicated in medulloblastoma. Both are tumor suppressor genes, genes that normally act as a brake on the development of cancer. If a mutation perturbs such a gene, cancer may then develop.

"Like other genes found in medulloblastoma, the MLL2 and MLL3 genes disrupt normal brain development during childhood," said co-author Peter C. Phillips, M.D., director of the Pediatric Neuro-oncology Program at The Children's Hospital of Philadelphia. "These genes interfere with biological signals during development, specifically with a process called histone methylation." In histone methylation, chemical tags that bind to DNA regulate how specific genes become active.

Both Curran and Phillips stressed the importance of collaboration among many institutions to the success of this study. "Even the largest oncology programs may see small numbers of medulloblastoma patients, so sharing data and materials is crucial to producing stronger statistical results," said Phillips. Children's Hospital and other centers have contributed resources and data to the Children's Brain Tumor Tissue Consortium, which provided tumor samples to the current study.

Direct clinical applications from this study are not immediate, but both researchers noted that clinical trials are already in progress to test whether inhibiting the Hedgehog pathway benefits medulloblastoma patients. Phillips added that the current study may lay a foundation for developing drugs that target the gene pathways associated with the MLL2 and MLL3 genes.


'/>"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

Related medicine news :

1. Docs Claim Transplant Cured Man of HIV, But Experts Urge Caution
2. Youth Sports Injuries Reaching Epidemic Levels, Experts Report
3. Put Ladder Safety on Your Holiday To-Do List, Experts Say
4. Gun-Safety Talk a Safe Bet for All Families, Experts Say
5. Experts question whether patients will use performance data to choose their care
6. Experts urge US to create emergency cholera vaccine stockpile for humanitarian use
7. Cholera and vaccine experts urge United States to stockpile vaccine
8. Holiday Drinking Can Kill, Experts Warn
9. Airport Body Scanners Safe, Experts Say
10. Military experts provide civilian surgeons with guidance on handling bomb blast injuries
11. Winter Skies Still Pose Sun Danger, Experts Warn
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2017)... ... 2017 , ... The Pennsylvania Athletic Trainers’ Society’s (PATS) Annual ... Convention Center on June 8-10. The weekend consisted of many educational presentations, ... scholarship presentations, and professional networking. , On Friday June 9th, PATS hosted ...
(Date:6/23/2017)... ... 2017 , ... The Rhode Island Quality Institute (RIQI) and ... Dashboards, an innovative new service enabling healthcare providers to proactively coordinate care and ... Dashboards provide near real-time data about patients admitted to and/or discharged from acute ...
(Date:6/23/2017)... ... ... Studies show evidence that carotenoids and antioxidants derived either from the diet or from ... how often do ophthalmologists and optometrists in Sweden recommend the use of nutritional supplements, ... symptoms of AMD? A study published recently in Dove Medical Press journal, ...
(Date:6/23/2017)... ... June 23, 2017 , ... Everybody has their own personal preference when ... read it, and some people don't like it at all. FindaTopDoc took a look ... , Erotic literature can give readers a taste of their deepest, darkest fantasies and ...
(Date:6/23/2017)... ... June 23, 2017 , ... Georgia State ... 18 to 20. , The two-day conference is focused on advancing scientific knowledge ... improving patients’ lives and eliminating racial breast cancer-related disparities. The conference theme is ...
Breaking Medicine News(10 mins):
(Date:6/8/2017)... 8, 2017  StatLab Medical Products ("StatLab" ... manufacturer of diagnostic supplies for the anatomic ... & Company LP ("Cressey & Company"), a ... growth-focused investment in the Company. Cressey & ... from selling shareholder, Prairie Capital, L.P., with ...
(Date:6/7/2017)... , June 7, 2017  Novavax, Inc., (Nasdaq: ... two Phase 2 trials of its RSV F protein recombinant ... bearing age have been published in the journal ... been shared in prior scientific conferences). The Company previously announced ... 2014. Novavax is developing the RSV F Vaccine with the ...
(Date:6/5/2017)... , June 5, 2017 The ... brand of Diplomat Pharmacy, Inc. (NYSE: DPLO), has been awarded ... Cincinnati Enquirer . Results are based on an ... in organizational health and workplace improvement. The survey measures several ... ...
Breaking Medicine Technology: