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CHOP, Penn Study is the First to Compare Treatments for HIV-Infected Children in Low-Resource Settings; Results Show Less-Used Regimen is More Effective
Date:4/30/2013

we move towards such changes, more work should be done to make efavirenz a more financially viable option for children on anti-retroviral therapy in these resource-limited settings.”

Previous studies favoring efavirenz over nevirapine in adults have resulted in treatment guidelines for adults in many countries, including a few in resource-limited settings, to recommend the use of efavirenz over nevirapine. “In these low-resource settings, Non-Government Organizations typically work with countries’ medical programs to forecast their HIV-related drug needs and lobby companies to lower prices for bulk purchases,” explained Lowenthal. “Through such programs, drugs that were once more expensive can become cost-effective.”

Doctors Lowenthal and Gross applaud the work that the government of Botswana has done to both bring high-quality HIV treatment to its citizens and to facilitate the generation of knowledge to help improve treatment options. “Botswana has been extremely supportive of clinical trials and epidemiological studies, and is very forward thinking in its willingness to inform the world. For such a small country, the amount of research that comes out of Botswana on HIV and tuberculosis is tremendous, which has not only benefitted their public health, but public health for all.”

To read the full study, “Association Between Efavirenz-Based Compared With Nevirapine-Based Antiretroviral Regimens and Virological Failure in HIV-Infected Children” visit http://media.jamanetwork.com.

About The Children’s Hospital of Philadelphia
The Children’s Hospital of Philadelphia was founded in 1855 as the nation’s first pediatric hospital. Through its long-standing commitment to providing exceptional patient care, training new generations of pediatric healthcare professionals and pioneering major research initiatives, Children’s Hospital has fostered many discoveries th
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