Navigation Links
CHIPSA Hospital Files Patent on Cancer Immunotherapy Combination of Checkpoint Inhibitors and Coley Vaccine
Date:9/15/2017

Preclinical and clinical data support efficacy of novel approach to cancer immunotherapy developed by CHIPSA hospital.

CHIPSA Hospital, dedicated to the accelerated development of nontoxic cancer immunotherapies announced today filing of a patent application covering the combination of FDA approved antibodies known as “checkpoint inhibitors” together with Coley Vaccine, a stimulatory of innate immunity. CHIPSA is the only licensed hospital facility (under doctor supervision) treating with the Coley’s Vaccine in North America.  The patent was based on animal data using the established B16 melanoma mouse model, as well as patient cases.

“CHIPSA is one of the oldest hospitals to be using Coley’s Vaccine therapy.  Our experiences and published literature suggests that Coley’s Vaccine is one of the most potent activators of the innate immune system[1],[2].  Given that cellular components of the innate immune system such as macrophage and dendritic cells play a fundamental role in the visibility of cancer to the immune system, we believe that activating these cells with Coley’s will increase responsiveness to checkpoint inhibitors.  This belief is supported by animal experiments and pilot human studies.” Said Edward Clay, Former CEO of CHIPSA Hospital and now Chief Executive of United Cancer Centers, as well as coinventor of the patent.

Currently, only about 20% of patients with advanced cancer respond to checkpoint inhibitors.  Data generated by CHIPSA collaborators and published data suggests that stimulating the innate immune system makes tumors more visible to the adaptive immune system, thus potentially increasing the number of patients responding to checkpoint inhibitors.

“The immunology behind this combined approach, which yielded synergistic antitumor effects, is very interesting in that checkpoint inhibitors, such as Yervoy, Keytruda, and Opdivo act to stimulate the adaptive part of the immune system, whereas Coley’s Vaccine activates the innate arm of the immune system.  Classical immunology teaches us that the innate and adaptive arms of the immune system work in synergy.  By concurrent activation of both of these arms of the immune system, we believe we are driving the immune system into a state of overdrive, thus overcoming tumor associated immune suppression and increasing probability of remission.” Said Dr. Thomas Ichim, coinventor of the patent.

“I am proud to have led the clinical implementation of combining Coley’s Vaccine, which has been used for more than 100 years, with cutting edge immunological treatments like checkpoint inhibitors.  The filing of today’s patent, is testimony to how here at CHIPSA we go the extra mile to offer the most advanced medicines to our patients.” Said Dr. Stephen Iacaboni, an Award Winning former MD Anderson Oncologist, who along with the other doctors at CHIPSA, performed the first combination therapies of Coley’s Vaccine with Checkpoint Inhibitors.

About CHIPSA

CHIPSA (Centro Hospitalario Internacional del Pacifico, S.A.) is a full service hospital caring for families with sick and injured within the ocean-front suburb of Playas de Tijuana.  Since inception in 1979, CHIPSA Gerson integrative medical practice has become world renown and has been long identified as the home of Mexico’ Center for Integrative Medicine and Research. Our founding legacy, Gerson Therapy, represents the original medical practice of immuno-nutrition therapy developed by Max B. Gerson, M.D. (founder of immune-nutrition) known for his many contributions to address chronic, degenerative and infectious disease, as well as the documentation and remission of cancer.

Contacts 

info(at)chipsahospital(dot)org

1-855-624-4772

Patient Inquiries

http://www.chipsahospital.org

1-855-624-4772

[1] Jessy T. Immunity over inability: The spontaneous regression of cancer. J Nat Sci Biol Med. 2011 Jan;2(1):43-9. [2 Maletzki et al. Reevaluating the concept of treating experimental tumors with a mixed bacterial vaccine: Coley's Toxin.  Clin Dev Immunol. 2012;2012:230625 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502841/

Read the full story at http://www.prweb.com/releases/2017/09/prweb14701489.htm.


'/>"/>
Source: PRWeb
Copyright©2017 Vocus, Inc.
All rights reserved


Related medicine news :

1. Martin General Hospital Partners with Specialists On Call to Offer Critical Care Services
2. BC Children’s Hospital Orthopaedic team creating first-ever global hip dysplasia registry and standardized assessment tool to benefit children worldwide
3. Joe DiMaggio Children’s Hospital Launches National Podcast Focused on Health and Parenting
4. First Texas Hospital and 28 First Choice Emergency Room Facilities Across Houston are Open and Operating 24/7 Post-Harvey
5. First Texas Hospital and 26 First Choice Emergency Room Facilities Across Houston are Open and Operating 24/7 Post-Harvey
6. 24/7 Intensive Care Unit Technology Comes to Florida Hospital Zephyrhills
7. Boston Strategic Partners, Inc. is utilizing Electronic Health Record Data to analyze hospital treated sepsis
8. T-System Offers Disaster Relief T Sheets Free of Charge to Hospitals Impacted by Hurricane Harvey
9. Hospitals Team Up to Fight Northeast Ohio Opioid Epidemic
10. US News & World Report’s High Performing Hospitals Ranks Arizona Spine & Joint for Knee Replacement
11. Allegheny Health Network’s Chief Nurse Executive Named to American Hospital Association Board
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/2/2018)... ... August 02, 2018 , ... Tunstall Americas has launched ... clients can partner with Tunstall Americas for After-hours call-handling, Overflow call-handling, and Appointment ... further expand their suite of Patient Access Solutions, and gives their existing and ...
(Date:8/1/2018)... ... August 01, 2018 , ... Matt ... and Vice President, Addiction Treatment Services, Behavioral Health Division of Universal ... Services business of Universal Health Services, which includes the FRN portfolio comprised of ...
(Date:8/1/2018)... Fla., and BOULDER, Colo., and LOS ANGELES (PRWEB) , ... August ... ... and Mixed Martial Arts (MMA) Athlete and two-time UFC Bantamweight Champion TJ Dillashaw have ... CBD product company that is on the FORBES Top 10 List of CBD Hemp ...
(Date:8/1/2018)... ... August 01, 2018 , ... The August 2018 official ... to the burgeoning Miami skyline. Penetron crystalline technology is a substantial part ... Aria on the Bay condominiums overlook Biscayne Bay and Miami. At a height of ...
(Date:8/1/2018)... ... ... Team Novo Nordisk, the world’s first all-diabetes professional cycling team, is bringing up ... the men’s pro squad as stagiaires for the remainder of the 2018 season. ... the development phase. One aspect of our strategy is to locate talented and promising ...
Breaking Medicine News(10 mins):
(Date:8/11/2018)... ... August 11, 2018 , ... ... August 13, with fun, games and gifts. Left-Handers are possibly the world’s largest ... right-handers. Having endured centuries of prejudice, countless indignities and inconveniences, left-handers quietly learn ...
(Date:8/9/2018)... (PRWEB) , ... August 09, 2018 , ... Cannabidiol, or ... of general public interest. That newly-garnered interest is precisely why National Day Calendar collaborated ... Among several candidates, cbdMD emerged as the founder of National CBD Day after weeks ...
(Date:8/7/2018)... MS (PRWEB) , ... August 06, 2018 , ... ... with gum disease in Clinton, MS using laser dentistry techniques. Using ... surgery with cutting-edge laser gum therapy called REPAIR Perio™. , Affecting the lives ...
Breaking Medicine Technology: