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CEL-SCI Presents Data at American College of Rheumatology Conference Which Suggests that CEL-2000 Has Potential to Slow Damage Caused by Rheumatoid Arthritis
Date:10/19/2009

, as indicated by deformation of foot joints (Arthritic Index (AI) score), of untreated, and CEL-2000 and Enbrel treated groups, was compared. In another study CEL-2000 was administered 5 times over a 70 day period and the animals were monitored for another 20 days for a total study period of 90 days. In each case, CEL-2000 treatment proved effective at blocking the progression of disease with statistically significant reduction in AI score compared to the appropriate controls and was safe and well tolerated without any adverse effects. The protection mediated by CEL-2000 treatment was also demonstrated histologically by significant reductions in 1) inflammation, 2) cartilage destruction 3) bone resorption, and 4) pannus membrane formation in the synovial space compared to untreated controls.

The CEL-2000 treatment appeared to change the course of the immune response in the diseased and treated animals by limiting the development of a destructive Th17 and tumor necrosis factor alpha (TNF-alpha) directed autoimmune response. Analysis of serum levels of 21 cytokines/chemokines indicated reductions in the characteristic cytokine markers of rheumatoid arthritis, TNF-alpha and IL-17, and also IL-6, and MCP-1. A number of cytokine changes were also seen with Enbrel treatment, but to a lesser degree.

CEL-2000 may also offer a number of potential advantages over existing rheumatoid arthritis treatments, such as Enbrel. Data collected in the animal studies conducted with CEL-2000 demonstrated that CEL-2000 is an effective treatment against arthritis even with the administration of fewer treatments. CEL-2000 is also potentially a more disease-type specific therapy, should be significantly less expensive and finally, CEL-2000 could also be useful for patients who are not able to take or who may be unresponsive to existing anti-arthritis therapies.

Rheumatoid arthritis treatments comprise a $13 billion market. Enbrel, a leading rheuma
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SOURCE CEL-SCI Corporation
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