Navigation Links
CDC Panel Says No to Routine Use of Gardasil for Boys
Date:10/21/2009

Doctors are free to offer HPV shot to males but widespread vaccination not advised

WEDNESDAY, Oct. 21 (HealthDay News) -- A U.S. advisory panel on Wednesday voted against the routine use of the vaccine Gardasil in boys and men, but did leave individual doctors free to recommend the vaccine for males as an option.

Gardasil protects against four strains of the human papilloma virus (HPV), a sexually transmitted pathogen that is thought to cause 70 percent of cervical cancers. HPV has also been linked to rarer cancers of the throat, genitals and anus, as well as genital warts, and its use among males has been the subject of much debate since Gardasil first received FDA approval for use in females in 2006.

However, the Advisory Committee on Immunization Practices, which reports its findings to the U.S. Centers for Disease Control and Prevention, stopped short of recommending the vaccine for boys as part of the approved childhood immunization schedule, Bloomberg News reported.

Earlier this month, the U.S. Food and Drug Administration approved Gardasil for the prevention genital warts in males aged 9 through 26.

Advocates for widening routine HPV immunization to males reason that since males transmit the virus to females, immunizing boys and young men might reduce cervical cancer rates.

But that argument sustained a serious blow earlier this month after a study found that the cost of giving boys the vaccine would outweigh any health benefit.

Researchers from the Harvard School of Public Health conducted an analysis comparing a girls-only vaccination program with a co-ed vaccination program.

"This study found that while vaccine coverage and efficacy are high in girls, including boys in an HPV vaccination program generally exceeds what the U.S. typically considers good value for money," lead researcher Jane Kim, an assistant professor of health decision science, said at the time of the study's release in the British Medical Journal.

Vaccination was considered a good value if cost-effectiveness ratios ranged from $50,000 to $100,000 per quality-adjusted life year, meaning the cost of the vaccine vs. the number of added years someone would gain by getting the vaccine.

Assuming 75 percent coverage and lifelong protection, the researchers found routine vaccination of 12-year-old girls was a good value at less than $50,000 per quality-adjusted life year. However, adding preadolescent boys increased the cost-effectiveness ratio to more than $100,000 per quality-adjusted life year. The researchers considered treatment for conditions caused by HPV, including anogenital and oral cancers, genital warts, and juvenile-onset recurrent respiratory papillomatosis.

"Only under optimistic assumptions of high, lifelong vaccine efficacy against all HPV-related health conditions, or lower vaccine efficacy accompanied by lower coverage or vaccine costs, did vaccinating both girls and boys fall below $100,000 per quality-adjusted life year," Kim said.

Debbie Saslow, director of breast and gynecologic cancer at the American Cancer Society, agreed with the findings.

"If we can vaccinate a high enough proportion of young girls, then vaccinating boys is not cost-effective," she said.

Reacting to the panel's vote on Wednesday, Gardasil's maker, Merck & Co, took issue with the ruling.

"Approximately 75 to 80 percent of males and females will acquire one or more types of HPV in their lives and HPV-related diseases cause significant personal and public health burden for both men and women," Merck spokeswoman Pam Eisele told Bloomberg. "As such, we believe there is value in vaccinating both young men and women with Gardasil to help protect them from certain diseases caused by HPV."

Since Gardasil's approval, studies have found it safe and nearly 100 percent effective in preventing precancerous cervical lesions from the four HPV strains targeted by the vaccine.

Studies have also found that Gardasil far more effective when given to girls or young women before they become sexually active.

In another vote on Wednesday, the ACIP panel approved the use of a second HPV vaccine, GlaxoSmithKline's Cervarix, for use in females to prevent cervical cancer. Last week, the FDA approved Cervarix for use in girls and women ages 10 to 26.

More information

For more on HPV vaccine, visit the U.S. Centers for Disease Control and Prevention.



SOURCES: Jane Kim, Ph.D., assistant professor, health decision science, Harvard School of Public Health, Boston; Philip E. Castle, Ph.D., M.P.H., investigator, division of cancer epidemiology and genetics, U.S. National Cancer Institute, Bethesda, Md. ; Debbie Saslow, Ph.D., director, breast and gynecologic cancer, American Cancer Society; Oct. 9, 2009, British Medical Journal online; Oct. 21, 2009, Bloomberg News


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Panel Intelligence Develops Extensive Access to Patient Populations in Oncology
2. Expert Panel of Pediatric Liver Specialists Publishes Recommendations for Monitoring and Referral of Children With Chronic Hepatitis B Infections
3. Oracle OpenWorld 2009 Panel to Feature Two Experts from National Healthcare Leadership Organizations -- the FDA and GS1 Healthcare US -- with Loftware and Oracle Representatives
4. Elaine Alquist, Willie Brown and Kim Belshe Convene Purple Ribbon Panel, Task Force on Alzheimers
5. Death Panel Inventor & Critic of Healthcare Reform Betsy McCaughey Has Close Ties to Philip Morris; Healthcare Industry Today Offers Complete Coverage
6. InfoLogix to Present Mobile in the Enterprise: Keeping up with User Demand While Containing Costs at Mobile Monday Panel in Philadelphia
7. Allied Worlds Nicole Baummer to Speak on Panel at National Employment Practices Liability Insurance ExecuSummit
8. Siperian to Host Webinar With Panel of Pharmaceutical Experts
9. FDA Panel Backs Giving HPV Vaccine Gardasil to Young Males
10. FDA Panel Weighs Approving HPV Vaccine for Males
11. Cepheid Announces Accelerated Development of Flu A Panel Test
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... Spain (PRWEB) , ... April 24, 2017 , ... ... on the development of next generation neuro-thrombectomy systems for the treatment of Acute ... and manufacture its ANCD BRAIN device as the product advances towards regulatory and ...
(Date:4/23/2017)... ... 2017 , ... "An event Horizon is a place where the laws of ... and Music. These are created as Metaphysical Transformations where music, which is the origin ... the ultimate singularity.", -- Karen Salicath Jamali , Karen will also preview her upcoming ...
(Date:4/22/2017)... ... ... Ecommerce sales have grown every year since the 1990’s, with 2016 retail ... of rapid innovation and growth are often neglected in the name of progress. As ... individual’s job to give something back to the planet that provides the resources needed ...
(Date:4/22/2017)... White Plains, NY (PRWEB) , ... April 22, ... ... Quarterly Report, which shows that U.S. consumers can save an average of 70% ... Even greater savings (up to 97%) are available when purchasing from other countries. ...
(Date:4/22/2017)... Capistrano (PRWEB) , ... April 22, 2017 , ... The San Juan Capistrano summer ... released a parenting report outlining the need for summer camps to provide physical activities for ... Importance of Physical Activity In Summer Camps , With an increase in specialty camps that ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)...  Sorrento Therapeutics, Inc. (NASDAQ: SRNE ... new treatments for cancer and other unmet medical ... announced underwritten public offering of 23,625,084 shares of ... of $2.00 per share, before deducting underwriting discounts ... Sorrento.  The net proceeds to Sorrento from this ...
(Date:4/19/2017)... April 19, 2017  Novartis today announced the ... Heart, Lung, and Blood Institute (NHLBI) of the ... of patients with treatment-naïve severe aplastic anemia (SAA) ... with eltrombopag at the initiation of and concurrently ... evaluated three sequential treatment groups, or cohorts. Cohort ...
(Date:4/18/2017)... April 18, 2017 Cogentix Medical, Inc. (NASDAQ: ... the Urology, Uro/Gyn and Gynecology markets with innovative and ... quarter ended March 31, 2017 after the market close ... Company will host a conference call and webcast to ... May 2, 2017 at 4:30 p.m. Eastern Time (3:30 ...
Breaking Medicine Technology: