Navigation Links
CD97 gene expression and function correlate with WT1 protein expression and glioma invasiveness
Date:2/7/2012

ree glioblastoma cell lines. Given CD97's putative role in aiding cell invasiveness and neoangiogenesis in other non-brain tumors, the decision was made to examine this cell-surface receptor specifically.

CD97 belongs to the adhesion G-proteincoupled receptor family. Western blot analysis demonstrated overexpression of CD97 protein in the three cell lines. Quantitative reverse transcriptasepolymerase chain reaction showed a six- to 21-fold increase in CD97 expression in the tumor cells over that found in normal human astrocytes, which displayed minimal CD97 expression. After siRNA transfection methods were applied to silence the CD97 gene, CD97 mRNA levels lowered significantly: approximately 50% in U251-MG cells, nearly 80% in GBM-6 cells, and 20% in U1242-MG cells. To examine whether these results would impact the glioblastoma cells' invasive capabilities, the researchers plated cells on Matrigel-coated filters of Transwell plates to see whether the cells would invade the Matrigel. In each cell type the cellular invasiveness potential decreased: to 54% of control (tumor cells) in U251-MG cells, approximately 50% of control in GBM-6 cells, and 26% of control in U1242-MG cells.

Perhaps the greatest challenge faced in treating malignant gliomas is their strong invasive capacity. The authors believe their data indicate that upregulation of CD97 mediated by WT1 possibly promotes this invasiveness. The findings of this study show a definite relationship between CD97 overexpression and the invasive quality of malignant glioma cells, which is correlated to the relationship between WT1 expression and the invasive characteristic of glioma cellsrelationships that in the future may be exploited in a therapeutic setting.


'/>"/>

Contact: Gillian Shasby
gshasby@thejns.org
434-924-5555
Journal of Neurosurgery Publishing Group
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Group settings can diminish expressions of intelligence, especially among women
2. Regulatory enzyme overexpression may protect against neurodegeneration in Huntingtons disease
3. Gene expression in mouse neural retina sequenced
4. Controlling gene expression to halt cancer growth
5. Novel technique reveals both gene number and protein expression simultaneously
6. High EGFR expression a predictor for improved survival with cetuximab plus chemotherapy
7. Gene expression changes in nasal cells may help identify lung cancer in earliest stages
8. Smokers undergo the same changes in gene expression as patients with COPD
9. Gene expression predicts chemotherapy sensitivity of triple-negative breast cancer
10. RxPONDER trial will evaluate whether gene expression test can drive chemotherapy choice
11. Low doses of penta-brominated diphenyl ether flame retardants alter gene expression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... (PRWEB) December 26, 2014 Pentec Health, ... in the state of Pennsylvania for 2014. The awards ... statewide programs of its kind in the country. The ... the Pennsylvania Department of Community and Economic Development, the ... Management and the Central Penn Business Journal. ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... 2014 Recently, iFitDress.com, the popular online supplier ... announced its new selection of black one-shoulder cocktail dresses ... now; they are available at discounted prices, up to 70% ... will last for three weeks only. You know, we have ... are interested in our new items can visit our website ...
(Date:12/25/2014)... December 25, 2014 Helen Harris’ RP ... Woodland Hills, California after an 8 year battle with ... Christmas Eve evening in her home in Woodland Hills ... breast cancer. , As the founder ... years, she pioneered and championed many of today's greatest ...
(Date:12/25/2014)... THURSDAY, Dec. 25, 2014 (HealthDay News) -- Overeating is common ... you eat in moderation, an expert says. "Don,t arrive ... up calories if you know you,ll be attending a party, ... Jill Ashbey-Pejoves, lead dietitian at Northern Westchester Hospital in Mount ... better to eat healthy during the day and even to ...
Breaking Medicine News(10 mins):Health News:Pentec Health Ranks Fourteenth on The Best Places to Work in PA for 2014 2Health News:Pentec Health Ranks Fourteenth on The Best Places to Work in PA for 2014 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:iFitDress.com: Black One-Shoulder Cocktail Dresses for 2015 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 4
... published in the April 25 early online edition of ... researchers at the University of California, San Diego ... and colleagues report a game-changing advance in stem cell ... cells from human embryonic stem cells (hESCs) that can ...
... pancreatitis that gets results much faster than existing tests has ... Austin. The sensor, which could be produced for as ... light, aluminum foil, gelatin, milk protein and a few other ... damage from acute pancreatitis, which is a sudden inflammation of ...
... , MONDAY, April 25 (HealthDay News) -- Most Americans ... many don,t understand the need to limit consumption, finds an ... mistakenly believe that sea salt is a low-sodium alternative to ... assess awareness about how wine and sodium affect heart health. ...
... Queen,s University have found a strong association between computer ... behaviours (MRB), including illicit drug use, drunkenness and unprotected ... theory, which suggests that seeing people engaged in a ... lead researcher Valerie Carson, a doctoral candidate in School ...
... given the slip by the protein fibulin-5 ... affects almost 50% of women over the age of ... a woman,s pelvic organs weaken such that the pelvic ... vagina. For many affected women, treatment involves surgery. Defining ...
... A new study suggests that it,s possible to predict future ... behavior. Bipolar people suffer from extreme mood swings ... deep depression. In the new study, researchers from the Universities ... bipolar patients for a month, studying how they think and ...
Cached Medicine News:Health News:Scientists create stable, self-renewing neural stem cells 2Health News:Self-powered, blood-activated sensor detects pancreatitis quickly and cheaply 2Health News:Many Americans Ill-Informed About Red Wine, Sea Salt: Survey 2Health News:JCI table of contents: April 25, 2011 2Health News:JCI table of contents: April 25, 2011 3Health News:JCI table of contents: April 25, 2011 4Health News:JCI table of contents: April 25, 2011 5Health News:JCI table of contents: April 25, 2011 6Health News:It May Be Possible to Predict Bipolar Mood Swings: Study 2
(Date:12/22/2014)... 22, 2014 Cyberonics, Inc. (NASDAQ: CYBX ... and management of epilepsy, today announced it will participate in ... Wednesday, January 14, 2015, in San Francisco ... Chief Executive Officer, will speak at 11:00 AM Pacific Time.  ... by clicking on the Investor Relations link on the Cyberonics ...
(Date:12/22/2014)... , Dec. 22, 2014 /PRNewswire/ -- RXi Pharmaceuticals Corporation ... focused on discovering, developing and commercializing innovative therapies ... today issued the following open letter to shareholders ... Dr. Med. Sc. Dear RXi Shareholders, ... number of inaccurate statements posted on certain social ...
(Date:12/22/2014)... , Dec, 22, 2014  Eiger BioPharmaceuticals ... 2a study of lonafarnib in patients with chronic ... conducted at the National Institutes of Health (NIH) ... .  The double-blinded, randomized, placebo-controlled, dose ascending study ... daily and 200 mg twice daily for 28 ...
Breaking Medicine Technology:RXi Pharmaceuticals Issues Open Letter to Shareholders 2RXi Pharmaceuticals Issues Open Letter to Shareholders 3RXi Pharmaceuticals Issues Open Letter to Shareholders 4RXi Pharmaceuticals Issues Open Letter to Shareholders 5RXi Pharmaceuticals Issues Open Letter to Shareholders 6Eiger Bio Announces Positive Data in Patients Infected with Hepatitis Delta Virus (HDV) Treated with Lonafarnib - Results Presented at American Association for the Study of Liver Diseases (AASLD) Meeting 2Eiger Bio Announces Positive Data in Patients Infected with Hepatitis Delta Virus (HDV) Treated with Lonafarnib - Results Presented at American Association for the Study of Liver Diseases (AASLD) Meeting 3
... The U.S. Food and Drug Administration today issued new ... needle-free clinical devices to administer influenza vaccinations. Based on ... ) immediately discontinued use of such clinical devices at ... The Kroger family of pharmacies and The Little ...
... HAYWARD, Calif., Oct. 21, 2011 Intarcia ... a letter of intent with Quintiles , the world,s ... 3 program for Intarcia,s ITCA 650 (DUROS® subcutaneous continuous delivery ... GLP-1 therapy to better address the unmet needs of the ...
Cached Medicine Technology:Intarcia and Quintiles Sign Letter of Intent for Innovative Global Collaboration to Advance ITCA 650 in Type 2 Diabetes 2Intarcia and Quintiles Sign Letter of Intent for Innovative Global Collaboration to Advance ITCA 650 in Type 2 Diabetes 3Intarcia and Quintiles Sign Letter of Intent for Innovative Global Collaboration to Advance ITCA 650 in Type 2 Diabetes 4
Used to obtain biopsy specimens from pathological lesions in the ureter, renal pelvis, infundibula, or calyces. Supplied sterile in peel-open packages. Intended for one-time use....
Used to obtain tissue biopsy under direct vision. Cup Biopsy Forceps are designed for use through rigid or flexible endoscopes. Supplied sterile in peel-open packages. Intended for one-time use....
... Series 1000 Power Instrument System is a ... and convenience with modular and unitized handpieces., ... for use with 1025 Power Console. Accepts ... Also available without hand throttle (#1000E) for ...
... Micro Drill, without hand throttle, ... torque. Built-in medium bur guard ... (#1100-006) bur guards are also ... foot throttle (#6401-000), can also ...
Medicine Products: