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CD97 gene expression and function correlate with WT1 protein expression and glioma invasiveness
Date:2/7/2012

ree glioblastoma cell lines. Given CD97's putative role in aiding cell invasiveness and neoangiogenesis in other non-brain tumors, the decision was made to examine this cell-surface receptor specifically.

CD97 belongs to the adhesion G-proteincoupled receptor family. Western blot analysis demonstrated overexpression of CD97 protein in the three cell lines. Quantitative reverse transcriptasepolymerase chain reaction showed a six- to 21-fold increase in CD97 expression in the tumor cells over that found in normal human astrocytes, which displayed minimal CD97 expression. After siRNA transfection methods were applied to silence the CD97 gene, CD97 mRNA levels lowered significantly: approximately 50% in U251-MG cells, nearly 80% in GBM-6 cells, and 20% in U1242-MG cells. To examine whether these results would impact the glioblastoma cells' invasive capabilities, the researchers plated cells on Matrigel-coated filters of Transwell plates to see whether the cells would invade the Matrigel. In each cell type the cellular invasiveness potential decreased: to 54% of control (tumor cells) in U251-MG cells, approximately 50% of control in GBM-6 cells, and 26% of control in U1242-MG cells.

Perhaps the greatest challenge faced in treating malignant gliomas is their strong invasive capacity. The authors believe their data indicate that upregulation of CD97 mediated by WT1 possibly promotes this invasiveness. The findings of this study show a definite relationship between CD97 overexpression and the invasive quality of malignant glioma cells, which is correlated to the relationship between WT1 expression and the invasive characteristic of glioma cellsrelationships that in the future may be exploited in a therapeutic setting.


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Contact: Gillian Shasby
gshasby@thejns.org
434-924-5555
Journal of Neurosurgery Publishing Group
Source:Eurekalert

Page: 1 2 3

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