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CD97 gene expression and function correlate with WT1 protein expression and glioma invasiveness
Date:2/7/2012

Charlottesville, VA (February 7, 2012). Researchers at Virginia Commonwealth University Medical Center's VCU Massey Cancer Center and Harold F. Young Neurosurgical Center (Richmond, VA) and Old Dominion University (Norfolk, VA) have discovered that suppression of Wilms tumor 1 protein (WT1) results in downregulation of CD97 gene expression in three glioblastoma cell lines and reduces the characteristic invasiveness exhibited by glial tumor cells. This finding is announced in the article, "Novel report of expression and function of CD97 in malignant gliomas: correlation with Wilms tumor 1 expression and glioma cell invasiveness," by Archana Chidambaram, Ph.D., and colleagues, published online ahead of print today in the Journal of Neurosurgery. Although further studies must be performed, the authors propose that CD97 may prove to be a new target for anti-glioma therapies.

According to William C. Broaddus, M.D., Ph.D., neurosurgeon and leader of the research team, "the invasive behavior of glioma cells is a key feature of their malignancy in the first place, and more recently there is evidence that treatment of gliomas with anti-angiogenic approaches such as bevacizumab (Avastin) may stimulate the invasive behavior of some gliomas. This may even serve as the mechanism by which these tumors fail to respond to bevacizumab treatment. That means that treatments to attack the invasiveness of gliomas by attacking CD97 expression may have special promise as a new treatment strategy."

WT1 is a transcription factor involved in the normal development of several tissue types. Usually expression of this protein is switched off when tissue reaches the normal adult stage. However, WT1 expression has been identified in numerous malignant diseasesleukemia, lung and breast cancers, sarcomas, reproductive organ tumors, and gliomas to name a few. In fact, the same team of researchers previ
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Contact: Gillian Shasby
gshasby@thejns.org
434-924-5555
Journal of Neurosurgery Publishing Group
Source:Eurekalert

Page: 1 2 3

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