Navigation Links
CD74 serves as a survival receptor on colon epithelial cells
Date:7/30/2010

CD74 is a protein that is expressed in and on cells of the immune system, such as B lymphocytes and antigen presenting cells. This protein is known for its function in facilitating antigen presentation enabling the immune response. Additionally, Professor Shachar's lab has previously shown that CD74 serves as a survival receptor on cells of the immune system, and that its stimulation by its natural ligand migration inhibitory factor (MIF)- prevents apoptosis (self destruction) of these cells. It was shown that CD74 is markedly expressed on numerous tumors - hematologic as well as epithelial, and can serve as a prognostic marker. CD74's expression and function on colon intestinal epithelial cells is controversial.

A research article to be published on July 14, 2010 in the World Journal of Gastroenterology addresses this question. A team of scientists headed by Professor Idit Shachar from the Weizmann Institute of Science in Israel, has demonstrated that CD74 is expressed on colon epithelial cells. CD74 expression on these cells was shown to increase colon epithelial cells survival upon stimulation by its natural ligand MIF. These findings were further supported by their demonstration in the mouse colorectal cancer cell line, CT-26. Stimulation of CD74 expressed on these cells led to Akt phophorylation and Bcl-2 expression resulting in elevation of cell survival.These findings may open a new target in the research of colorectal cancer.


'/>"/>

Contact: Lin Tian
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1

Related medicine news :

1. National Prosthodontics Awareness Week Serves and Educates Consumers About Proper Oral Health Care
2. First Virtual Optical Store Serves Military Personnel
3. Transplant drug preserves kidneys, avoids toxicity
4. Heel-First Walking Conserves Energy
5. Vaccine Boosts Survival for Men With Advanced Prostate Cancer: Study
6. NIH-funded study finds early HAART during TB treatment boosts survival rate in co-infected people
7. Threats of Global Warming Spark Environmentalists to Create Global Warming Survival Center
8. Traditional neurologic exams inadequate for predicting survival of cardiac arrest patients
9. Lung cancer research concludes that early diagnosis as key for improving survival
10. The Healthcare Survival Guide Wins Prestigious Independent Book Publishers Association Benjamin Franklin Award
11. Health Plan May Influence 5-Year Rectal Cancer Survival
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... City, Oklahoma (PRWEB) , ... June 25, 2016 ... ... helping both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic ... the Oklahoma City area —Johnson is one of the first doctors to perform ...
(Date:6/24/2016)... ... 2016 , ... A recent article published June 14 on E ... goes on to state that individuals are now more comfortable seeking to undergo not ... as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians ...
(Date:6/24/2016)... ... ... Marcy was in a crisis. Her son James, eight, was out of control. Prone to ... , “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there ... my other children and say he was going to kill them. If we were ...
(Date:6/24/2016)... ... 24, 2016 , ... Dr. Amanda Cheng, an orthodontist ... has extensive experience with all areas of orthodontics, including robotic Suresmile technology, ... , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can be used ...
(Date:6/24/2016)... , ... June 24, 2016 , ... People across the ... Genome magazine’s Code Talker Award, an essay contest in which patients and their families ... to be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... Story Highlights: ... the health care industry is causing providers to review ... Deloitte offers a suite of solutions for health care ... cost optimization: labor resource analysis, revenue cycle optimization and ... outcomes and better economics ...
(Date:6/24/2016)... Calif. , June 24, 2016  Global ... a biopharmaceutical company developing novel therapeutics for the ... needs, today announced the closing of its previously ... common stock, at the public offering price of ... the offering were offered by GBT. GBT estimates ...
(Date:6/24/2016)... , June 24, 2016 ... the "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural ... Structural electronics involves electronic and/or ... protective structures, replacing dumb structures such as vehicle ...
Breaking Medicine Technology: