Navigation Links
CD74 serves as a survival receptor on colon epithelial cells
Date:7/30/2010

CD74 is a protein that is expressed in and on cells of the immune system, such as B lymphocytes and antigen presenting cells. This protein is known for its function in facilitating antigen presentation enabling the immune response. Additionally, Professor Shachar's lab has previously shown that CD74 serves as a survival receptor on cells of the immune system, and that its stimulation by its natural ligand migration inhibitory factor (MIF)- prevents apoptosis (self destruction) of these cells. It was shown that CD74 is markedly expressed on numerous tumors - hematologic as well as epithelial, and can serve as a prognostic marker. CD74's expression and function on colon intestinal epithelial cells is controversial.

A research article to be published on July 14, 2010 in the World Journal of Gastroenterology addresses this question. A team of scientists headed by Professor Idit Shachar from the Weizmann Institute of Science in Israel, has demonstrated that CD74 is expressed on colon epithelial cells. CD74 expression on these cells was shown to increase colon epithelial cells survival upon stimulation by its natural ligand MIF. These findings were further supported by their demonstration in the mouse colorectal cancer cell line, CT-26. Stimulation of CD74 expressed on these cells led to Akt phophorylation and Bcl-2 expression resulting in elevation of cell survival.These findings may open a new target in the research of colorectal cancer.


'/>"/>

Contact: Lin Tian
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1

Related medicine news :

1. National Prosthodontics Awareness Week Serves and Educates Consumers About Proper Oral Health Care
2. First Virtual Optical Store Serves Military Personnel
3. Transplant drug preserves kidneys, avoids toxicity
4. Heel-First Walking Conserves Energy
5. Vaccine Boosts Survival for Men With Advanced Prostate Cancer: Study
6. NIH-funded study finds early HAART during TB treatment boosts survival rate in co-infected people
7. Threats of Global Warming Spark Environmentalists to Create Global Warming Survival Center
8. Traditional neurologic exams inadequate for predicting survival of cardiac arrest patients
9. Lung cancer research concludes that early diagnosis as key for improving survival
10. The Healthcare Survival Guide Wins Prestigious Independent Book Publishers Association Benjamin Franklin Award
11. Health Plan May Influence 5-Year Rectal Cancer Survival
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... , ... June 01, 2016 , ... A book about ... New Renaissance ” (published by Balboa Press AU) attempts to give readers the courage ... , β€œThe Divine has inspired and guided me throughout my life to learn ...
(Date:5/31/2016)... Hollywood, Fl (PRWEB) , ... May 31, 2016 ... ... the doors to its new Concussion Clinic serving South Florida. , The ... sports medicine, pediatric neurology, pediatric physical medicine and rehabilitation, pediatric neuropsychology and also ...
(Date:5/31/2016)... (PRWEB) , ... June 01, 2016 , ... ... β€œ Psoriasis and smoking: links and risks ”. , As corresponding author Professor ... on the relation between smoking habits and psoriasis. Smoking influences the onset and ...
(Date:5/31/2016)... ... ... adults often find themselves reaching for a cup of coffee, an energy drink, or even ... is a cup of Matcha green tea. Matcha is a premium green tea powder made ... early June to mid-July, when the leaves are the most tender. , Matcha ...
(Date:5/31/2016)... ... 2016 , ... Splashtop Inc., the worldwide leader in high performance cross-screen ... the leading provider of secure mobile remote access solution for Japan enterprises. ... access solution. Splashtop for CACHATTO will be available as an integrated add-on ...
Breaking Medicine News(10 mins):
(Date:5/30/2016)... , May 30, 2016 ... report "Healthcare Biometrics Market by Technology (Single-factor ... Multifactor, Multimodal), Application (Workforce Management), End User ... 2021", published by MarketsandMarkets, the market is ... 2021 from USD 1,182.6 Million by 2016, ...
(Date:5/30/2016)... 30, 2016 LifeScienceIndustryResearch.com adds ... research report with comprehensive information on the therapeutic ... at various stages, therapeutics assessment by drug target, ... and molecule type, along with latest updates, and ... key players involved in the therapeutic development for ...
(Date:5/27/2016)... , May 27, 2016 ... innovative biopharma company focused on the highly lucrative ... a substantial pipeline of potential first-in-class or best-in-class ... are in development with strategic partners. HCM,s profitable ... fast-growing domestic market. We expect progress of the ...
Breaking Medicine Technology: