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CARRE Foundation selects TGen for unprecedented research into causes of multiple system atrophy
Date:8/30/2013

man of Nestl Waters North America, who worked with CARRE to assemble $100,000 for the study, said that like many rare disorders, there has been limited funding and few studies of MSA. "We and the other supporters of this new TGen-led research hope to turn that around and make real progress in helping those whose lives have been shattered by this disease."

Nestl's support of TGen was prompted, in large part, by a desire to help Rex Griswold.

"Rex has been a vital force for our company for more than two decades, and it seems inconceivable that he might be slowed by such a rare and puzzling disorder," Jeffery said. "Despite his diagnosis, Rex continues to perform in a positive, determined way, and his fighting spirit is coming through."

MSA is rare, affecting fewer than 5 in every 100,000. It attacks the cerebellum, the area of the hindbrain that controls motor movement, coordination, balance, equilibrium and muscle tone. The cause of MSA is unknown, but the typical age of onset is in the late 50s. Also called Shy-Drager Syndrome, there is no cure and not even a treatment that can slow its progression.

Now, TGen's research can provide hope for Rex Griswold and others afflicted by this mysterious disease that cuts down adults in their prime.

TGen's technologically advanced whole genome sequencingspelling out an individual's genetic codeshould provide a comprehensive look at the genetic changes that might cause MSA. TGen proposes to use whole genome sequencing coupled with specific family-based investigations to uncover novel genetic associations with MSA.

"TGen's sharper tools and simpler methods will allow an in-depth analysis of the MSA genome," said Dr. Jeffrey Trent, TGen President and Research Director. "We seek to apply these tools in a defined patient population in hopes of providing information to scientists and physicians so we can benefit those patients who need our help today."

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Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

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