Navigation Links
C-Reactive Protein Levels Vary By Race: Study

By Steven Reinberg
HealthDay Reporter

TUESDAY, Sept. 28 (HealthDay News) -- Levels of the blood biomarker C-reactive protein (CRP) can vary among different racial and ethnic groups, which might be a key in determining heart-disease risk and the value of cholesterol-lowering drugs, a new British study suggests.

CRP is a sign of inflammation, and elevated levels have been linked -- but not proven -- to an increased risk for heart disease. Cholesterol-lowering drugs called statins can reduce heart risk and CRP, but it's not clear if lowering levels of CRP helps to reduce heart-disease risk.

"The difference in CRP between populations was sufficiently large as to influence how many people from different populations would be considered at high risk of heart attack based on an isolated CRP measurement and would also affect the proportion of people eligible for statin treatment," said study researcher Aroon D. Hingorani, a professor of genetic epidemiology and British Heart Foundation Senior Research Fellow at University College London.

"The results of the current study indicate they [physicians] should bear ethnicity in mind in interpreting the CRP value," she added.

The report is published in the Sept. 28 online edition of Circulation: Cardiovascular Genetics.

For the study, Hingorani and her colleagues reviewed 89 studies that included more than 221,000 people. They found that CRP levels differed by race and ethnicity, with blacks having the highest levels at an average of 2.6 milligrams per liter (mg/L) of blood. Hispanics were next (2.51 mg/L), followed by South Asians (2.34 mg/L), whites (2.03 mg/L), and East Asians (1.01 mg/L).

The U.S. Food and Drug Administration recently approved using one statin, rosuvastatin (Crestor), to prevent heart disease in men over 50 and women over 60 who have at least one risk factor for heart disease and CRP greater than 2 mg/L, Hingorani's group noted.

Using that criteria, more than half of blacks and Hispanics would probably have CRP levels of 2 mg/L at 50 years of age, while fewer than half of East Asians would have that CRP level at age 50, the study authors said.

At age 60, less than 40 percent of East Asians, but almost two-thirds of blacks and Hispanics would probably have a CRP level higher than 2mg/L, the researchers said.

"The differences in CRP between populations may be partly genetically determined, and partly [explained] by differences in diet, lifestyle and other heart attack risk factors," Hingorani said. "However, most of the difference in CRP between populations is currently unexplained," she added.

The American Heart Association says "CRP may be used at the discretion of the physician as part of a global coronary risk assessment in adults without known cardiovascular disease." A CRP value above 3 mg/L is considered high risk for heart disease, according to the association.

Dr. Gregg Fonarow, an American Heart Association spokesman and cardiology professor at the University of California, Los Angeles, noted that CRP has been "increasing utilized as a component of cardiovascular risk prediction and to identify among intermediate risk patients the ones that may benefit the most from statin therapy for primary prevention."

"This study highlights that further studies are needed to develop and validate cardiovascular risk prediction tools for all the major ethnic groups, so that effective primary prevention therapies can be optimally targeted to those who will benefit the most," he added.

More information

To learn more about C-reactive protein, visit the American Heart Association.

SOURCES: Aroon D. Hingorani, Ph.D., professor of genetic epidemiology and British Heart Foundation Senior Research Fellow, University College London; Gregg Fonarow, M.D., American Heart Association spokesman and professor, cardiology, University of California, Los Angeles; Sept. 28, 2010, Circulation: Cardiovascular Genetics, online

Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Protein key to growth of pancreatic cancer
2. Nonstick coating of a protein found in semen reduces HIV infection
3. Protein clamps tight to telomeres to help prevent aging ... and support cancer
4. Protein clamps tight to telomeres to help prevent aging...and support cancer
5. Scripps Research scientists solve long-standing mystery of protein quality control mechanism
6. Function found for Alzheimers protein
7. Misfolded neural proteins linked to autism disorders
8. Will extra protein and exercise help dialysis patients? U of I profs get $2.1 million to find out
9. Researchers zero in on protein that destroys HIV
10. Munich researchers demonstrate rocking movement in the anti-stress protein Hsp90
11. Rheumatoid arthritis signaling protein reverses Alzheimers disease in mouse model
Post Your Comments:
(Date:6/25/2016)... Beach, CA (PRWEB) , ... June 25, 2016 , ... ... UCLA with Magna Cum Laude and his M.D from the David Geffen School of ... Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at the ...
(Date:6/24/2016)... Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... surgery procedures that most people are unfamiliar with. The article goes on to state ... procedures, but also many of these less common operations such as calf and cheek ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Sessions in Dallas that it will receive two significant new grants to support ... as PHA marked its 25th anniversary by recognizing patients, medical professionals and scientists ...
(Date:6/24/2016)... ... , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business ... to $12 an hour by 2020 and then adjusting it yearly to increase at the ... minimum wage, assure the wage floor does not erode again, and make future increases more ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Investment Group (TGIG), has initiated cultivation and processing operations at its production facility, ... Pahrump, Nevada. , Puradigm is the manufacturer of a complete system of proactive ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Bracket , a ... its next generation clinical outcomes platform, Bracket eCOA (SM) ... on June 26 – 30, 2016 in Philadelphia ... electronic Clinical Outcome Assessment product of its kind to fully ... Bracket eCOA 6.0 is a flexible platform for ...
(Date:6/23/2016)... Ill. and INDIANAPOLIS , ... students receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship is ... 2016 scholarship winners, announced today online at ... let type 1 diabetes stand in the way of ... has supported the Foundation,s scholarship program since 2012, and ...
(Date:6/23/2016)... , June 23, 2016 ... Oticon , industry leaders in advanced ... launch of Oticon Opn ™, the world,s first ... of possibilities for IoT devices.      (Photo: ... Oticon introduces a number of ,world firsts,: ...
Breaking Medicine Technology: