Navigation Links
Bypassing Immune Rejection in Stem-Cell-Based Therapies
Date:8/16/2013

Durham, NC (PRWEB) August 16, 2013

The scientific community has held tremendous hope for the eventual emergence of stem cell transplantation as a broadly applicable and highly effective therapeutic strategy. However, the realization of this hope has been plagued by the indomitable immune response to the transplantation of human embryonic stem cell (hESC) derivatives, which prevents the engraftment and long-term survival necessary for functional recovery or preservation of the host tissue.

In an article featured in the latest issue of STEM CELLS, a research group from Stanford University describes a novel regimen for quashing this immunologic barrier — a short-course treatment with two costimlation-adhesion blockade agents, allowing engraftment of transplanted differentiated stem cells and their prolonged survival in tissue.

"Inducing immune tolerance to human embryonic stem cell graft is critical for the clinical success of regenerative medicine,” commented Dr. Joseph Wu, M.D., Professor of Medicine and Radiology at the Stanford University School of Medicine. “We have realized, however, that traditional immunosuppressive therapies used to prevent solid organ rejection, such as calcineurin inhibitors and corticosteroids, are insufficient to prevent human embryonic stem cell rejection following transplantation.”

In the study, hESCs were made to express enhanced green fluorescent protein (eGFP), differentiated to endothelial cells and cardiomyocytes, and transplanted into mouse hindlimbs as well as into both healthy and ischemic mouse myocardia. A novel costimulation-adhesion blockade method was then used alongside a more traditional therapy involving cyclosporine to induce immunosuppression. Detection of eGFP in the tissues allowed the team to track the engraftment and longevity of the transplanted cells over time. The costimulation-adhesion method yielded vastly superior results to the cyclosporine tr
'/>"/>

Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. Nanodrug targeting breast cancer cells from the inside adds weapon: Immune system attack
2. Ohio State researchers restore immune function in spinal injured mice
3. Immune system molecule promotes tumor resistance to anti-angiogenic therapy
4. The American Academy of Anti-Aging Medicine (A4M) to host Gut, Brain, and Autoimmune Disorders: the Role of Food Symposium in Los Angeles, CA August 16-17, 2013
5. Premature aging of immune cells in joints of kids with chronic arthritis, Pitt team says
6. Isolated psychiatric episodes rare, but possible, in common form of autoimmune encephalitis
7. Mount Sinai researchers discover mechanism behind development of autoimmune hepatitis
8. Poor sleep in pregnancy can disrupt the immune system and cause birth-related complications
9. Targeting errant immune system enzyme kills myelodysplastic cells
10. Removal of tumor-associated immune cell protein decreases tumor progression
11. Maintaining immune balance involves an unconventional mechanism of T cell regulation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... cancer were more likely to be diagnosed with ... and survived for shorter times than prostate cancer ... has found. , The negative outcomes may be ... against the mentally ill, depression,s impact on biological ... in his general health and disinterest in receiving ...
(Date:7/10/2014)... and cakes that are just as tempting as ... thanks to fresh insights into how proteins can ... , Funded by the Engineering and Physical ... University and the University of Edinburgh has produced ... and therefore closely mimic the behaviour of fats ...
(Date:7/10/2014)... WACO, Texas (July 10, 2014) Men who experience ... but they may find relief from their silent suffering ... treatment, according to findings from a Baylor University case ... 69-year-old man who had uncontrolled hot flashes following prostate ... hot flashes but also an impressive improvement in sleep ...
(Date:7/9/2014)... -- The World Health Organization recommends that youth participate ... vigorous physical activity (MVPA) each day. Studies have ... school hours. Therefore, it stands to reason that ... In a new study scheduled for publication in ... time spent outdoors after school was positively associated with ...
(Date:7/9/2014)... For the first time, researchers have access to ... Canada uses health care. A new study, called Our ... the unique challenges faced by urban Aboriginal people in ... , The findings, published today in BMJ ... individuals and the general population. , Researchers interviewed 554 ...
Breaking Medicine News(10 mins):Health News:Depressed men with prostate cancer are diagnosed later stage, get less effective therapies 2Health News:Great tasting low-fat cheeses and cakes could soon be on the menu 2Health News:Men's hot flashes: Hypnotic relaxation may ease the discomfort men don't talk about 2Health News:Men's hot flashes: Hypnotic relaxation may ease the discomfort men don't talk about 3Health News:Men's hot flashes: Hypnotic relaxation may ease the discomfort men don't talk about 4Health News:Go play outside! Outdoor time promotes physical activity in youth 2Health News:Urban Aboriginal people face unique health challenges 2
... Dr. James Melvin, Director of the Center for ... of the 2008 Salivary Research Award from the International ... 86th General Session & Exhibition in Toronto, ON, Canada ... Case Western Reserve University, Cleveland, Ohio, in 1978 and ...
... recipient of the 2008 Behavioral, Epidemiological and Health Services,Research ... for Dental Research (IADR) at its 86th General,Session & ... Dr. Atchison is a Professor in the Division of ... the Vice-,Provost of Intellectual Property & Industrial Relations at ...
... 25 New research that explores,the tactics and strategies ... now available in the Best Practice Database, an,online research ... To review sample key findings and key metrics ... to each study at this address:, http://www3.best-in-class.com/dr319.htm , ...
... door to improved treatments , , WEDNESDAY, June 25 (HealthDay News) ... it easier for people to develop Alzheimer,s disease, and it ... new work not only provides a better understanding of the ... as an important target for therapy," said Philippe Marambaud, an ...
... prostate cancer treatments in ... according to Millennium Research Group, WALTHAM, Mass., June ... of over 140 US and European based urologists,during the ... this study are analyzed in the US and European,Urologist ...
... skin cancer self-examination, LOS ANGELES, June 25 ... service initiative that partners with organizations,and individuals to ... has tapped actress Malin Akerman to educate consumers ... detection. As the #1,dermatologist recommended skincare brand and ...
Cached Medicine News:Health News:Atchison receives Behavioral, Epidemiological and Health Services Research Award 2Health News:Best Practice Database Adds Research on New Product Commercialization 2Health News:Gene Variant May Contribute to Alzheimer's Disease 2Health News:Adoption of Minimally Invasive Prostate Cancer Treatment Options Slow 2Health News:Neutrogena(R) Partnership For Skin Health Taps Malin Akerman to Educate About Skin Cancer Detection 2Health News:Neutrogena(R) Partnership For Skin Health Taps Malin Akerman to Educate About Skin Cancer Detection 3
(Date:1/14/2014)... Dynamic Healthcare Services, Inc. ("DHS"), a portfolio company of GMH ... Medical Equipment, Inc. ("Progressive") of Clarion, PA ... were not disclosed. Progressive is a full ... of sleep, mobility, and respiratory products to customers in the ...
(Date:1/14/2014)... , Jan. 14, 2014 Animal Emergency Critical Care, a LifeCentre ... Leesburg, Virginia is the first in Loudoun ... Dr. Susan M. Barnes , Medical Director, ... and husband, Dr. Cole Taylor , are avid scuba divers. ...
(Date:1/14/2014)... NineSigma , Inc., the leading innovation partner to organizations ... May 14-16, 2014 at the Global Center for Health ... This is the premier industry event for ... open innovation. Participants will learn how world-changing innovation is ...
Breaking Medicine Technology:Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 3Hyperbaric Veterinary Medicine (hvm) Announces Animal Emergency Critical Care Installs A Small Animal Hyperbaric Chamber 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 3Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 4
... NORTH BRUNSWICK, N.J., July 20, 2011 Artegraft, Inc. ... in the June 2011 issue of the Journal ... Bovine Carotid Artery vascular grafts (BCA) to cuffed ePTFE ... that the BCA graft had significantly higher primary and ...
... SUNNYVALE, Calif., July 20, 2011 Accuray ... premier radiation oncology company, will host a symposium ... oncology at the 2011 Joint American Association of ... (COMP) Meeting. The symposium—" Best Quality Assurance Programs ...
Cached Medicine Technology:Study Published in Journal of Vascular Surgery Confirms Superiority of Artegraft BCA to Cuffed ePTFE for Hemodialysis Access 2Accuray Hosts Symposium on Quality Assurance in Radiation Oncology at Joint AAPM/COMP Meeting 2
... Raintree Billing Manager and Collections ... centralized or de-centralized billing models and ... collection ratios with the ability to ... single claims more directly from the ...
A.I.med's medical billing software is a medical billing software. The billing module integrates with A.I.med's Electronic Medical Record software. A.I.med's medical billing module also integrates wit...
... The Infinity Amylase EPS single liquid ... the convenience of single liquid stability ... operator error and provide quick result ... the InfinityTM Amylase EPS reagent provides ...
... (Nitrogen) powder reagent once reconstituted offers the ... stability to help maximize laboratory productivity, minimize ... time. The patented technology of the Infinity ... shelf life and stability once reconstituted that ...
Medicine Products: