Navigation Links
By studying animal health, researchers find improved ways for developing, testing cancer therapies
Date:8/15/2012

MANHATTAN, KAN. -- A group of Kansas State University researchers has made valuable findings in the search for cancer's cure.

While researching ways to improve animal health, the scientists -- Raymond "Bob" Rowland, a virologist and professor of diagnostic medicine and pathobiology, and Deryl Troyer, professor of anatomy and physiology --have made two important discoveries that can also improve human health. Not only have they found pigs with severe combined immunodeficiency, or SCID, but they are also the first to discover the connection with human cancer, particularly melanomas and pancreatic cancers.

The researchers call it a scientific achievement with huge potential to improve surgeries and drug development involved with cancer.

"This could be a game-changer," Troyer said.

It began with Rowland's research with controlling and eliminating porcine reproductive and respiratory syndrome, or PRRS. The work led to a fortuitous discovery: a naturally occurring line of immunodeficient pigs.

"Pigs are closely related to humans anatomically and physiologically," Rowland said. "This can have huge potential for human cancer research."

After the discovery of SCID pigs, Rowland turned to Troyer, who performs cancer research. Their collaborative work not only enables researchers to better study SCID pigs, but they can also apply their research to the study of human cancer and anti-cancer drugs.

"This is a great example of collaborative and interdisciplinary research," Troyer said. "With two perspectives, there is often a synergy that evolves because of different ways of thinking."

The researchers have already studied human melanomas and human pancreatic cancers, which are devastating types of cancer and a big target in cancer research, Troyer said. They want to apply the same methods to other types of solid cancers and blood neoplasms like leukemia.

While similar research has been performed with SCID mice, it has not adapted well to human cancer research. Rowland said there is about a 90 percent failure rate in translation of results from mice to humans. Research involving SCID pigs may be more beneficial to human cancer research because pigs are closer anatomically to humans.

The research opens a variety of doors for both animal and human health research. It may now be easier for scientists to improve strategies for bone marrow transplants. They also have a better way to detect cancer drug side effects and test surgical interventions, Troyer said.

"The potential is a little daunting because it is as if there is no horizon limiting possible ways to utilize this model, " Troyer said. "It is an opportunity for Kansas State University to be a leader in the field and to become a center for large animal biomedical research."

For Rowland, the discovery also opens new doors for infectious disease research.

"There are a lot of pig diseases for which we still don't know how they function and how they cause disease," Rowland said. "Now we are able to ask the question, 'What role does the immune system play in clearing the virus or in causing disease?'"

The research also improves the study of zoonotic diseases, which are diseases -- like swine influenza -- that can be transmitted between animals and humans. By developing vaccines for diseases in SCID pigs, scientists can gain insight into human vaccine development. The university's Biosecurity Research Institute provides the ideal location for developing these vaccines, Rowland said.

The scientists have performed research on a small scale and now want to build it up to a larger scale. They see possibilities for new research with the Kansas State University Johnson Cancer Research Center as well as cancer research partnerships and collaborations with the University of Kansas Cancer Center, especially with its recent National Cancer Institute designation.

"Agriculture benefits the people of the state in so many ways," Rowland said. "While it includes jobs and exports, there is a human element that we sometimes forget. This is a good example of how we can take animal health research and all of a sudden it has the potential to help cure human cancer."

The research recently appeared in the journal BioResearch Open Access. Rowland and Troyer have another upcoming publication in the Journal of Veterinary Pathology.


'/>"/>

Contact: Raymond "Bob" Rowland
browland@k-state.edu
785-532-4631
Kansas State University
Source:Eurekalert

Related medicine news :

1. Studying couples to improve health, better relationships
2. Study finds US among few NATO nations that use animals for military training
3. TRPM7 protein key to breast cancer metastasis in animal models
4. New drug successfully halts fibrosis in animal model of liver disease
5. New influenza virus from seals highlights the risks of pandemic flu from animals
6. Olympic-Class Athletes Abound in Animal Kingdom
7. Lab-engineered muscle implants restore function in animals
8. New animal model may lead to treatments for common liver disease
9. Potential treatment target identified in an animal model of pancreatic cancer
10. New technique could reduce number of animals needed to test chemical safety
11. Chicago Dog Bite Injury Lawyers Advise Dog Owners To Get Control of Their Animals, Or Be Prepared To Pay Up
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2017)... , ... January 23, 2017 , ... ... and high-level training standards for healthcare treatment providers who treat the full spectrum ... Presidents Council. , The Presidents Council consists of the leading eating disorder ...
(Date:1/23/2017)... ... January 23, 2017 , ... Sharon Kleyne, America’s leading water researcher, ... listeners about the benefits of making new water infrastructure a number one priority. “As ... that we expect water infrastructure to become a top priority of our new political ...
(Date:1/23/2017)... ... January 23, 2017 , ... ... Crystallization in Process Chemistry by Applying Simple PAT Tools . , ... to isolate and purify the desired product. Chemists now spend more time ...
(Date:1/23/2017)... ... January 23, 2017 , ... "ProRandom is a set of camera tools that allow ... looks in Final Cut Pro X," said Christina Austin - CEO of Pixel Film Studios. ... layers of text with video footage. ProRandom works by using a virtual camera to ...
(Date:1/23/2017)... ... 23, 2017 , ... Gynecology Associates of Gwinnett (GAoG) has ... for women of all ages. The staff of Gynecology Associates of Gwinnett ... from routine health screenings to diagnosing and treating female concerns including menopause, urinary ...
Breaking Medicine News(10 mins):
(Date:1/21/2017)... , Jan. 20, 2017 ARMO BioSciences, ... clinical data on the Company,s lead investigational immuno-oncology drug ... co-sponsored by the American Society of Clinical Oncology (ASCO), ... Francisco, CA. "AM0010 induces ... CD8 + T cells in the blood and ...
(Date:1/20/2017)... 2017 Research and Markets has announced ... ([CBC, HGB/HCT, BMP, BUN Creatinine, Electrolyte Testing, HbA1c Testing, Comprehensive Metabolic ... Forecasts, 2013 - 2024" report to their offering. ... The global clinical laboratory ... Introduction of innovative solutions on the grounds of maximum ...
(Date:1/20/2017)... Research and Markets has announced the addition of the ... to their offering. ... This research service on the global pharmaceutical stability testing market ... of the key participants in the market. The ... 2020. The market is expected to grow at a CAGR of ...
Breaking Medicine Technology: