Navigation Links
By shutting down inflammation, agent reverses damage from spinal cord injury in preclinical studies
Date:3/31/2009

Washington, DC Researchers at Georgetown University Medical Center (GUMC) have been able to speed recovery and substantially reduce damage resulting from spinal cord injury in preclinical studies.

Their research, published online in Annals of Neurology and led by Kimberly Byrnes, PhD, shows that inflammation following injury causes the neurotoxicity that leads to lasting nerve cell damage, and that an experimental agent is able to block this inflammatory reaction.

"The findings we have made in this study may potentially be applicable to other neurological disorders, including stroke, head injury, Alzheimer's disease and Parkinson's disease," says senior investigator Alan I. Faden, MD, a professor of neuroscience and director of the Laboratory for the Study of Central Nervous System Injury at GUMC.

Faden says that the experimental agent they tested (CHPG), an activator of a type of glutamate receptor, is not ideal for human use because it cannot easily penetrate the blood-brain barrier. But he adds, "now that we know the biological target, a new drug could be designed that is better suited for clinical treatment of these neurodegenerative disorders."

CHPG shuts down activation of key immune cells in the brain known as microglia, which sense pathogens or damage in the spinal cord and brain. They helpfully foster the destruction of microbial invaders and clean up biological detritus that occurs after an injury, but researchers say they have a dark side as well they can worsen the damage by releasing toxic inflammatory factors.

"Under certain conditions, like spinal cord injury and brain trauma, microglia become activated," Faden says. "They release toxic chemicals that can kill healthy adjacent tissue, and this process can continue for months.

"We have found that six months after an injury, the expression of certain inflammatory factors in the spinal cord is 4-5 times normal levels," he says, adding that it has been shown that after human trauma, brain tissue can continue to be lost even more than a year after the injury. "Microglial related toxicity may contribute to this progressive loss," says Faden.

The study is a continuation of a long line of research by this investigative group that aims to stop that persistent damage. The team had previously found that microglial cells express a certain receptor, the group I metabotropic glutamate receptor 5 (mGluR5), on their surface. Further work showed that if these receptors were specifically activated on microglia, these immune cells would not produce the neurotoxins that led to cell death near the site of injury. CHPG serves to selectively activate the receptor, reducing microglial toxicity.


'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

Related medicine news :

1. Community & Mission Hospital of Huntington Park Shutting Down Mission Campus, Terminating Workers
2. Pathway links inflammation, angiogenesis and breast cancer
3. Mergent, Inc. Announces Changes to the HealthShares(TM) Composite, Enabling Technologies, Autoimmune-Inflammation, Cancer, Cardiology and Neuroscience Indexes
4. Inflammation, depression and antidepressant response: Common mechanisms
5. Is 4 agents decoction (Si Wu Tang) efficacious in treating primary dysmenorrhea?
6. Investigational Agent Targeting Metabotropic Glutamate 2/3 Receptors Demonstrates Antipsychotic Activity in Humans, Study in Nature Medicine Finds
7. Replidyne Pipeline Featured at 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy
8. MassMutual Agent Honored by Insurance Industry for Extraordinary Service to Client
9. Sagent Pharmaceuticals Inc. Completes $53 Million Series A Financing
10. ABR-Affinity BioReagents Expands 100% Quality Guarantee
11. Inside job: new radioactive agents for colon cancer work inside cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... ... February 05, 2016 , ... The American public tends to feel uncomfortable about ... than regular municipal or well water. The recent experience with lead contaminated water in ... a long way toward increasing public acceptance of recycled waste water as drinking water. ...
(Date:2/5/2016)... ... February 05, 2016 , ... Give To Cure ... search for and donate to Give To Cure’s campaign that is crowdfunding clinical trials ... users make and share payments through a smart device. In 2015 alone, Venmo processed ...
(Date:2/5/2016)... ... February 05, 2016 , ... Pivot Point Consulting, ... in KLAS: Software & Services for HIT Implementation Support & Staffing report with ... ranks vendor performance by healthcare executives, managers and clinicians representing over 4,500 hospitals ...
(Date:2/5/2016)... ... 05, 2016 , ... Dr. Justin Scott and Dr. Lydia Muccioli of ... Day to individuals in need. The event is scheduled to take place on February ... is to provide dental care to community members in need. Each patient will be ...
(Date:2/5/2016)... ... February 05, 2016 , ... Dr. Ben ... that it is now welcoming orthodontist, Dr. Amanda Cheng, to the practice. With ... of oral health care, including general dentistry, cosmetic treatments, periodontics, implant dentistry ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... 5, 2016 Dehaier Medical Systems Ltd. ... "Company"), which develops, markets and sells medical devices ... China and international markets, today announced ... to concentrate the Company,s resources to develop its ... and to focus more on its major businesses. ...
(Date:2/5/2016)... Feb. 5, 2016  Henry Schein, Inc. (NASDAQ: HSIC ... and services to office-based dental, animal health and medical ... agreement to acquire a majority ownership interest in Dental ... in Brazil . ... Dental Cremer is the dental distribution business of Cremer ...
(Date:2/5/2016)... http://www.researchandmarkets.com/research/hcdvg6/global_obstetrics ) has ... Obstetrics Partnering 2010-2016: Deal trends, players and ... --> http://www.researchandmarkets.com/research/hcdvg6/global_obstetrics ) has announced ... Partnering 2010-2016: Deal trends, players and financials" ... --> Research and Markets ( http://www.researchandmarkets.com/research/hcdvg6/global_obstetrics ...
Breaking Medicine Technology: