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Bursting bubbles with sound offers new treatments for cancer
Date:6/28/2010

A new way to deliver cancer drugs using gas bubbles and sound waves is to be developed at the University of Leeds. The project will enable highly toxic drugs to be delivered in small doses directly to tumours, where their toxicity can safely be put to good use. If successful, the technique could easily be adapted for other diseases.

The project brings together engineers, physicists, chemists and cancer specialists from across the University to work on the new technique. The research will use existing chemotherapy drugs to gain initial proof of concept before adapting the delivery mechanism for use with novel therapeutics being developed at the University to treat colorectal cancer.

Tiny gas-filled bubbles just a 1000nth of a millimetre across are already used in medicine to provide a clearer image on ultrasound scanners, because, when they are injected into the bloodstream, they reflect a stronger signal than the surrounding tissue. However, certain ultrasound signals will burst the bubbles and it is this phenomenon that the researchers plan to exploit as a clever cancer treatment.

The researchers will attach the drug to microbubbles, along with antibodies that are attracted to the tumour to make the bubbles congregate at the tumour site. Ultrasound will then be applied to the site at the correct frequency, and when the bubbles burst a manageable but effective dose of the drug will be released. An added benefit is that ultrasound can also temporarily rupture cell membranes, helping to get the drug into the cells where it can be most effective.

Lead researcher Professor Stephen Evans says: "A number of research teams are looking at possible uses for microbubbles, but with the breadth of expertise available at Leeds we're in a good position to make a breakthrough. For the technique to be a viable clinical and commercial option, we not only need to find a reliable way to attach the drugs and antibodies, we also need to be able to ma
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Contact: Jo Kelly
jokelly@campuspr.co.uk
44-113-258-9880
University of Leeds
Source:Eurekalert

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