Navigation Links
Burnham researchers illuminate mechanisms that regulate DNA damage control and replication
Date:1/5/2009

LA JOLLA, Calif., January 5, 2008Scientists at Burnham Institute for Medical Research (Burnham) have demonstrated important new roles for the protein kinase complex Cdc7/Dbf4 or Cdc7/Drf1 (Ddk) in monitoring damage control during DNA replication and reinitiating replication following DNA repair. Since Ddk is often deregulated in human cancers, this new understanding of its role in DNA damage control could help shape new cancer therapies. The research was published in the December 24 issue of Molecular Cell.

Accurate DNA replication is essential for maintaining the stability of the genome. When errors occur, replication halts through a quality control process called the S-phase checkpoint. Replication is only restarted after the errors have been repaired. One of several proteins required for DNA replication, Ddk has long been thought to play an important role in the S-phase checkpoint, despite the lack of definitive evidence. In this study, Burnham researchers show that Ddk actively controls S-phase checkpoint signaling and plays a crucial role in triggering the re-initiation of DNA replication once damage has been repaired.

"This protein kinase complex is not only monitoring DNA replication, it's also monitoring the S-phase checkpoint," says Wei Jiang, Ph.D., the study's principal investigator. "If replication is accurate, then Ddk allows DNA synthesis to continue normally. If there is DNA damage, replication is halted at this checkpoint. The most important thing is to stop replication in order to allow for DNA repair and to avoid catastrophe for the cell. Our study demonstrates that Ddk not only activates the initiation of DNA replication, but it also monitors the checkpoint during DNA damage control and eventually overrides the checkpoint to re-initiates DNA replication."

These findings suggest a highly complex role for Ddk in DNA replication, S-phase checkpoint monitoring and DNA replication re-initiation after repair. The roles of Ddk in controlling the DNA replication machinery for genome stability and fidelity may make it an excellent target for the development of new cancer treatments.


'/>"/>

Contact: Josh Baxt
jbaxt@burnham.org
858-795-5236
Burnham Institute
Source:Eurekalert

Related medicine news :

1. Burnham and HeadNorth Foundation join forces to advance spinal cord research
2. Recent developments at Burnham Institute
3. Recent developments at the Burnham Institute
4. Relocation plan of metastatic cancer cells uncovered by Stanford researchers
5. Researchers at Columbia University Medical Center link blood sugar to normal cognitive aging
6. Researchers create smaller, brighter probe tailored for molecular imaging and tumor targeting
7. Nutritious fast-food kids meals are scarce, researchers find
8. UIC researchers hunting drugs for devastating parasitic disease
9. Indiana University researchers revisit male bisexuality
10. Breast cancer risk varies in young women with benign breast disease, Mayo Clinic researchers say
11. Mayo researchers find potential links between breast density and breast cancer risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating to Best Buy ... in the United States and Canada wear eyeglasses. Once considered to be a purely ... make a fashion statement. Even celebrities use glasses as a way of creating an ...
(Date:6/26/2016)... ... 2016 , ... PawPaws brand pet supplements owned by Whole Health ... the health of felines. The formula is all-natural and is made from Chinese herbs ... Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia ...
(Date:6/25/2016)... Austin, TX (PRWEB) , ... June 25, 2016 , ... ... Fellow of the American College of Mohs Surgery and to Dr. Russell Peckham for ... popular and highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic ...
(Date:6/25/2016)... , ... June 25, 2016 , ... As a lifelong ... Cum Laude and his M.D from the David Geffen School of Medicine at UCLA. ... to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai ...
(Date:6/24/2016)... Los Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... plastic surgery procedures that most people are unfamiliar with. The article goes on to ... known procedures, but also many of these less common operations such as calf and ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016 Dehaier Medical Systems Ltd. ... which develops, markets and sells medical devices and wearable ... signed a strategic cooperation agreement with Hongyuan Supply Chain ... Chain") on June 20, 2016, to develop Dehaier,s new ... cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s sales ...
(Date:6/24/2016)... , Belgium , June ... MKT: VNRX), today announced the appointment of Dr. ... of Directors as a Non-Executive Director, effective June ... Company,s Audit, Compensation and Nominations and Governance Committees.  ... Dr. Futcher will provide independent expertise and strategic ...
(Date:6/23/2016)... 23, 2016 Research and Markets ... Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic ... Coating, Parenteral) - Global Forecast to 2021" report ... The global pharmaceutical excipients market is projected to ... of 6.1% in the forecast period 2016 to 2021. ...
Breaking Medicine Technology: