Navigation Links
Buprenorphine is better than methadone for opioid dependence in pregnant women, study shows
Date:12/9/2010

Using buprenorphine instead of methadone the current standard of care to treat opioid-dependent pregnant women may result in healthier babies, suggests new findings from an international team led by Johns Hopkins researchers and published in the Dec. 9 issue of the New England Journal of Medicine.

Babies born to mothers taking buprenorphine instead of methadone to counter heroin and/or prescription opioid addiction were likely to need less morphine to deal with drug withdrawal symptoms, spent half as much time in the hospital after delivery and recovered from neonatal abstinence syndrome in half as much time, the study found. Neonatal abstinence syndrome, caused when a fetus is exposed to heroin and/or prescription opioids in the womb, can cause hyperirritability and autonomic nervous system dysfunction, often requiring medication and extended hospital stays for babies born with it.

"In newborns, buprenorphine produces a milder withdrawal than methadone," says study leader Hendree Jones, Ph.D., a professor of psychiatry and behavioral sciences at the Johns Hopkins University School of Medicine. "Our results support the use of buprenorphine as the treatment of choice for opioid dependence in pregnant women."

"The use of buprenorphine as an alternative treatment for opioid dependence during pregnancy had not been well studied," she adds, "making this research important in showing that buprenorphine is a better treatment option than methadone."

Jones cautions that buprenorphine is not for every opioid-dependent pregnant woman. Future research will focus on which drug is right for which type of patient, she says.

The study, an eight-site, double-blind, randomized, controlled trial titled The Maternal Opioid Treatment: Human Experimental Research (MOTHER) project, compared buprenorphine and methadone in the comprehensive care of 175 opioid-dependent women, ages 18 to 40, who were six to 30 weeks' pregnant.

Although not specifically FDA approved for such use, methadone, a synthetic opiate, is the accepted and recommended treatment for opioid dependence during pregnancy. Patients including pregnant women are prescribed methadone in an effort to keep them away from dangerous and illegal street drugs, including heroin, and the risky life issues associated with procuring and taking illegal drugs. Buprenorphine, a newer compound, is comparable to methadone, and both create similar side effects and outcomes for the mother.

Study participants received extensive prenatal and postnatal care and monitoring. Their care plans included psychological evaluations, blood work, sonograms, daily clinic visits, weekly questionnaires, a non-stress test, case management, and group and individual counseling. The mothers and newborns also were monitored for 28 days following delivery.


'/>"/>

Contact: Karen Tong
ktong4@jhmi.edu
410-550-0128
Johns Hopkins Medical Institutions
Source:Eurekalert

Related medicine news :

1. UTHealth study suggests private insurers control health care spending better than Medicare
2. Good grades in high school lead to better health, study finds
3. Cognitively-impaired human research subjects need better protection
4. Contaminated Butter Points to Need for Better Surveillance, Study Says
5. Littlest Kids in Big Day-Care Centers May Have Better Health Later On
6. Better imaging from bench to bedside
7. Active surveillance for low-risk prostate cancer may offer better quality-of-life
8. Better Outcomes Seen With Early Rheumatoid Arthritis Diagnosis
9. Screening tool may better identify heart disease in African-Americans
10. Work Teams Who Share Negative Emotions Better at Problem-Solving
11. Better Helmet Design Might Lower Soldiers Risk for Brain Injury
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... ... April 28, 2016 , ... Sanford Health’s work ... A group of researchers and leaders from Sanford Health were selected to participate ... Its Cultural Impact ” and receive the 2016 Pontifical Key Innovation Award at ...
(Date:4/28/2016)... CA (PRWEB) , ... April 28, 2016 , ... La ... currently number one in Central America and is looking to grow their market share ... for such an exceptional brand as La Sirena Foods and indirectly with ...
(Date:4/28/2016)... ... 28, 2016 , ... Head Over Heels Athletic Arts’ gymnast, Brooklyn Varize, has ... be held at the University of Montana on April 28-May 1. Varize will compete ... , In order to qualify, Varize needed to place top seven all-around in her ...
(Date:4/28/2016)... ... April 28, 2016 , ... The ... a new CDISC standard, Clinical Trial Registry (CTR) XML. Clinical trial registries ... will make it possible to build applications that generate submissions for multiple, ...
(Date:4/28/2016)... ... 28, 2016 , ... Cosmetic Town, an online plastic surgery community, announces the ... was recently revamped and upgraded to allow even more interaction between doctors and patients ... , According to the senior editor of Cosmetic Town, “We are excited that our ...
Breaking Medicine News(10 mins):
(Date:4/26/2016)... , April 26, 2016 Hill-Rom Holdings, Inc. ... a management presentation at the Deutsche Bank 41 st ... 2:50 p.m. EDT. You are invited to listen ... http://ir.hill-rom.com/events.cfm or access it directly at http://edge.media-server.com/m/p/mr4uxgas . ... hour after conclusion of the live event and accessible at ...
(Date:4/26/2016)... DUBLIN , April 26, 2016 ... "Financial Assessment and Credit Risk Analysis of the Biological ... This comprehensive report analyzes the financial assessment ... China . The report provides readers ... key topics all market participants should be aware of. ...
(Date:4/26/2016)... April 26, 2016 ... 2016;9(1):16-20 DOI: http://doi.org/10.17925/USOR.2016.09.01.16 ... Published recently in US Ophthalmic Review, ... Davidson discusses how laser cataract surgery ... cataract surgery: the laser fragments the lens ...
Breaking Medicine Technology: